signal transduction

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1ANXA1-FPR1ANXA1_HUMAN - FPR1_HUMANLigand-ReceptorSignaling by Annexin
2ANXA1-FPR3ANXA1_HUMAN - FPR3_HUMANLigand-ReceptorSignaling by Annexin
3ARTN-GFRA1+RETARTN_HUMAN - Ligand-ReceptorSignaling by RET receptors
4ARTN-GFRA3+RETARTN_HUMAN - Ligand-ReceptorSignaling by RET receptors
5BMP15+GDF2-ACVR1B+BMPR1B+BMPR2 - Ligand-ReceptorSignaling by BMP
6BMP8A-ACVR1+ACVR2BBMP8A_HUMAN - Ligand-ReceptorSignaling by BMP
7BMP8A-ACVR2B+BMPR1ABMP8A_HUMAN - Ligand-ReceptorSignaling by BMP
8BMP8A-ACVR2B+BMPR1BBMP8A_HUMAN - Ligand-ReceptorSignaling by BMP
9CCL20-CCR6CCL20_HUMAN - CCR6_HUMANLigand-ReceptorSignaling by Chemokines
10CEACAM1-CEACAM6CEAM1_HUMAN - CEAM6_HUMANAdhesion-AdhesionAdhesion by CEAM
11CNTF-CNTFR+IL6ST+LIFRCNTF_HUMAN - Ligand-Receptor
12CXCL1-CXCR2GROA_HUMAN - CXCR2_HUMANLigand-ReceptorSignaling by Chemokines
13CXCL5-CXCR2CXCL5_HUMAN - CXCR2_HUMANLigand-ReceptorSignaling by Chemokines
14CXCL6-CXCR2CXCL6_HUMAN - CXCR2_HUMANLigand-ReceptorSignaling by Chemokines
15CXCL8-CXCR2IL8_HUMAN - CXCR2_HUMANLigand-ReceptorSignaling by Chemokines
16EDN3-EDNRAEDN3_HUMAN - EDNRA_HUMANLigand-ReceptorSignaling by Endothelin
17EPO-EPOREPO_HUMAN - EPOR_HUMANLigand-Receptor
18FASLG-FASTNFL6_HUMAN - TNR6_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
19GAS6-AXLGAS6_HUMAN - UFO_HUMANLigand-ReceptorSignaling by Growth arrest
20GAS6-TYRO3GAS6_HUMAN - TYRO3_HUMANLigand-ReceptorSignaling by Growth arrest
21GDF1-ACVR1B+ACVR2BGDF1_HUMAN - Ligand-ReceptorSignaling by Growth differentiation factor
22GDF3-ACVR1B+ACVR2BGDF3_HUMAN - Ligand-ReceptorSignaling by Growth differentiation factor
23GDNF-GFRA1+RETGDNF_HUMAN - Ligand-Receptor
24HBEGF-EGFRHBEGF_HUMAN - EGFR_HUMANLigand-ReceptorSignaling by Epidermal growth factor
25HBEGF-ERBB2HBEGF_HUMAN - ERBB2_HUMANLigand-ReceptorSignaling by Epidermal growth factor
26HBEGF-ERBB4HBEGF_HUMAN - ERBB4_HUMANLigand-ReceptorSignaling by Epidermal growth factor
27IGF1-GPC3+IGF1RIGF1_HUMAN - Ligand-ReceptorSignaling by Insulin-like growth factor
28IGF1-IGF1RIGF1_HUMAN - IGF1R_HUMANLigand-ReceptorSignaling by Insulin-like growth factor
29IL12B+IL23A-IL12RB1+IL23R - Ligand-ReceptorSignaling by Interleukin
30IL13-IL13RA1+IL4RIL13_HUMAN - Ligand-ReceptorSignaling by Interleukin
31IL15-IL15RA+IL2RBIL15_HUMAN - Ligand-ReceptorSignaling by Interleukin
32IL21-IL21R+IL2RGIL21_HUMAN - Ligand-ReceptorSignaling by Interleukin
33IL22-IL10RB+IL22RA1IL22_HUMAN - Ligand-ReceptorSignaling by Interleukin
34IL26-IL10RB+IL20RAIL26_HUMAN - Ligand-ReceptorSignaling by Interleukin
35IL36RN-IL1RAP+IL1RL2I36RA_HUMAN - Ligand-ReceptorSignaling by Interleukin
36IL9-IL2RG+IL9RIL9_HUMAN - Ligand-ReceptorSignaling by Interleukin
37INHA-ACVR1B+ACVR2AINHA_HUMAN - Ligand-ReceptorSignaling by Inhibin/Activin
38INHA-ACVR1B+ACVR2BINHA_HUMAN - Ligand-ReceptorSignaling by Inhibin/Activin
39INHA-ACVR1C+ACVR2BINHA_HUMAN - Ligand-ReceptorSignaling by Inhibin/Activin
40INHA-ACVR1+ACVR2BINHA_HUMAN - Ligand-ReceptorSignaling by Inhibin/Activin
41INHA+INHBA-ACVR1B+ACVR2A - Ligand-ReceptorSignaling by Inhibin/Activin
42INHA+INHBA-ACVR1B+ACVR2B - Ligand-ReceptorSignaling by Inhibin/Activin
43INHA+INHBA-ACVR1C+ACVR2B - Ligand-ReceptorSignaling by Inhibin/Activin
44INHA+INHBA-ACVR1+ACVR2B - Ligand-ReceptorSignaling by Inhibin/Activin
45INHA+INHBB-ACVR1B+ACVR2A - Ligand-ReceptorSignaling by Inhibin/Activin
46INHA+INHBB-ACVR1B+ACVR2B - Ligand-ReceptorSignaling by Inhibin/Activin
47INHA+INHBB-ACVR1C+ACVR2B - Ligand-ReceptorSignaling by Inhibin/Activin
48INHA+INHBB-ACVR1+ACVR2B - Ligand-ReceptorSignaling by Inhibin/Activin
49INHBC-ACVR2BINHBC_HUMAN - AVR2B_HUMANLigand-ReceptorSignaling by Inhibin/Activin
50INHBE-ACVR2BINHBE_HUMAN - AVR2B_HUMANLigand-ReceptorSignaling by Inhibin/Activin
51LTB-LTBRTNFC_HUMAN - TNR3_HUMANLigand-ReceptorSignaling by Lipoxin/Leukotriene
52MDK-ALKMK_HUMAN - ALK_HUMANLigand-ReceptorSignaling by Midkine
53MICA-HCST+KLRK1MICA_HUMAN - Ligand-Receptor
54NRG2-ERBB3NRG2_HUMAN - ERBB3_HUMANLigand-ReceptorSignaling by Neuregulin
55NRG2-ERBB4NRG2_HUMAN - ERBB4_HUMANLigand-ReceptorSignaling by Neuregulin
56PECAM1-CD38PECA1_HUMAN - CD38_HUMANReceptor-Receptor
57PGF-NRP1PLGF_HUMAN - NRP1_HUMANLigand-ReceptorSignaling by Placenta growth factor
58PLAU-PLAURUROK_HUMAN - UPAR_HUMANLigand-ReceptorSignaling by Plasminogen Activator
59SCT-VIPR2SECR_HUMAN - VIPR2_HUMANLigand-ReceptorSignaling by Secretin
60TAFA4-FPR1TAFA4_HUMAN - FPR1_HUMANLigand-ReceptorSignaling by TAFA
61TNFSF10-TNFRSF10ATNF10_HUMAN - TR10A_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
62TNFSF10-TNFRSF10DTNF10_HUMAN - TR10D_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
63TNFSF10-TNFRSF11BTNF10_HUMAN - TR11B_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
64TNFSF12-TNFRSF25TNF12_HUMAN - TNR25_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
65TNFSF13-TNFRSF17TNF13_HUMAN - TNR17_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
66TNFSF13B-TNFRSF17TN13B_HUMAN - TNR17_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
67TNFSF14-LTBRTNF14_HUMAN - TNR3_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
68TNFSF15-TNFRSF25TNF15_HUMAN - TNR25_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
69TNFSF18-TNFRSF18TNF18_HUMAN - TNR18_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
70TNFSF8-TNFRSF8TNFL8_HUMAN - TNR8_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
71ULBP1-HCST+KLRK1N2DL1_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
72UTS2-UTS2RUTS2_HUMAN - UR2R_HUMANLigand-ReceptorSignaling by Urocortin/Urotensin
73UTS2B-UTS2RUTS2B_HUMAN - UR2R_HUMANLigand-ReceptorSignaling by Urocortin/Urotensin
74WNT11-SFRP5WNT11_HUMAN - SFRP5_HUMANLigand-LigandSignaling by WNT inhibition
75WNT11-WIF1WNT11_HUMAN - WIF1_HUMANLigand-LigandSignaling by WNT inhibition
76WNT8B-SFRP5WNT8B_HUMAN - SFRP5_HUMANLigand-LigandSignaling by WNT inhibition
77WNT8B-WIF1WNT8B_HUMAN - WIF1_HUMANLigand-LigandSignaling by WNT inhibition

II. Literature review

[source]
Namesignal transduction
IDGO_0007165
collection_id

Biological process

Alternative ID

GO:0023014, GO:0023015, GO:0023016, GO:0023033, GO:0023045

Description

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Related synonym

signaling pathway, signalling pathway

Comment

Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.

External URL
Genes
NPHP1PLAANLRP12KITINHBEOR1J2BST1PSDATMinterleukin12_humanIL1BGFERGRB14CHRNA5ARHGEF7AKAP9IL19PRKAG1TRAF3TOM1L1BEX3ARHGAP19GNAI2TNFSF8EDN3RARBMFHAS1GRIA2ELK3SIT1CAP2SNX27NR1I2ITPKBDOCK1METRNLPPP2R5BRANBP1MRGPRX1CEACAM6NFKBIBOR7G1NPR3PTGESTNFSF12TGFBR1NCR1GNG11IL24ACVR2BOR1D4GNG10NRGNWNT8BCYTL1C1QTNF9ABL2C5AR1ANK3MIARHPN2TEX2CNGB3RHPN1GPNMBTHNSL2SERGEFERGFAM83FEDARADDCXCL10ARHGAP42GPIOGNSHOC2RHOHPLPP1RASD1TIE1ACVRL1IL9ADCY3PGFCOPS3ZFYVE16PHLPP2CDK3ERBB3ITPK1ARAP3GREM1FAM3DPTPRTRASSF7RABEP2SRCCCN1SYDE2CD274PRKCZWNT11MAP2K5RIN1LRP8CHRNA3LRRC58GNA11CD244ANK1METRNP2RX3FGF11UTS2RMICAL1CCN5INHBCCNGA3NRXN1ARRB1IL1RL1NMBYWHAQCGB7RASSF8CMTM8IL7RSLC39A12ARHGAP40RTKN2OR7G2ERBB4STARD13MX1CSNK1EFAM83ETLE1IL5RAOR7G3KNG1HGSTAMALINVRK1CSNK2BLMBR1AKAP10PPFIA1LRRC63LRRC18HMGB1ARHGAP25OR1G1CD38ARR3FAM13BHDGFL3OR1E3TSPEARINPP1DOK1MOB3AITGB1BP2ARAP1LTAHLXDAPP1XCL1ANGPTL8IL25LRRC30ECM1DLL4GNRH1RBPJLPTK7RHOQNR2E3RAF1GLDNBARGINSMAD5FASGABRB3MLNMAPKAPK3RALAINS-IGF2CAP1PRKD1MAP3K6NR1I3IL13ITPR2IL20CTTNPSTPIP1OR7C2CRHBPTRHTTBK2ITGALPPP1R12ACOL15A1DOK2CAPN5RLN2SMPD1AKAP5WWP1CHRNDSTAMIGF2RGDI1GUCA1AIQGAP1MAPK10PI4KBOR8S1JAK2OR7D4ADORA1NPHP4CSF2RBARHGAP12SCGB3A1ARTNBCAR3LRRN2OGTSCUBE2GMFGGIPTMIGD3CORO1CRHOBTMEM102MAGI2FPR3LRPAP1RCVRNAKAP12CSNK1G2STACMYD88DPYSL2ARHGAP22ITPKAMKLN1IL12RB1GUCA2ACDKL2OR52A1ULK2VRK2IL18R1PEX11BPPP2R5DTRIM55OR1Q1DLG5GDF15MACC1MAPK1FBN2ESR2NLRP1BMP1VAV2TOLLIPFAM83DTRAF5CRHMST1RCD200R1DGKDPDE11ACEACAM20AKAP4RADILRASIP1SIGIRRPI4KALGALS3BPNOSTRINPSG8PPP1R1BTRIP10NOX1HDGFTCP11L2REG1ACLEC2BMYOCCBLCARHGAP11AGNA13CLIC3CXCL9SRGAP1PYCARDARHGAP26PLPPR2HSPA1AOR7A10DRG2PTPRMCASKIN1HLA-DRB1GABRQPRKAB1CASP1FAM13APPP2R5EOPTNHBEGFDTNAGASTIRS1FEZ2TLE3OLFML2BPLPPR5GRNLRRC2TMDD1PLA2G1BAKT2CSPG5RETTENM2VLDLRCRIPTO3GMFBCD83ATF6BARFRP1OLFM4GRIA1AKAP8SRGAP2TRADDRPS6KA6STK11FGF1PEX11AP2RX1PRKAB2SNX17RHBDL1NLRP3PLAUFGF2RNF14MYO10TLR1IGFBP1CEACAM3PKP1CEACAM4ANXA5ASIPRIT1CSNK1DFNBP1LGRAP2CHRNA6OR1F1OLFML2ASTK4SH3BP5ADCY8FGF13A0A499FJF3TNFSF10ACVR1BENDOURPS6KA3YWHAZTMEM116CDS1DPYSL5PPARGLRRC28FGF16TRIM54GABRB1DIRAS1EGFRATF6SIPA1OPN1SWCCL23P2RX6CASP8AP2TYMPOR1D5FAM3BSH2D2ARTKNGNGT1OR1A1RAPGEF3PIK3CDMAPK12ALCAMCDC42SE1RHOFICOSLGOLFML1GUCY1A2ARHGAP44TRIM63COPS2STARD8RASSF5RAP2BFGF20CBLIMPA1GEMAKT1MAP3K10RHODSTC1ANGPT2KLRK1TCP11L1SIRPB1POMCRPS6KB1ANKDD1AARL2BPPCNTCDK4OR1S2SECTM1CCL18APPL1PKN1IPO8EDNRAIL22CXCL11PAG1RETNIL1RL2IAPPCXCL14RASSF9IGF1RCCL1GPR27PTK2BTGTNFAIP6ANKDD1BOXSR1SPXTLR6PMCHL2CLCN6CCN4CGB3OR7A2POR7A5CD34FAM83BOLFM1ULBP1PDCLKIR2DL4SH3BP2FAM83HSPARCL1IGF1CCL2SRGAP3PPP4R1OSGIN1BCAMMAP2K6TNFRSF18NBL1CKLFNCK2SFNBMP3CLEC5ATNFRSF8VGFCHRNGMAP2K7CDNFOSTF1MAVSinsulin_humanPKN3SIGLEC8MAGI3CALCBOR1N1OR1L8EPONR3C2PRKCHPIK3CBTRAF4RASAL1LRRC40RASD2CREB1CHN2LSP1CHRM1CCN6GPR143PDAP1ENHOLRP12CABP5RALBFGF14CD53XCL2STAM2CEACAM7CNTFGDI2SPP1GAB3IGFBP4ANXA4BMXRLN1ADMPTPRRTLR2CARTPTCHRM3NDRG1GABRA6ITPR1RPS6KB2PLPP2OR1S1CTNND2CHRNA4THOC1PRKG2MAPK14TNFRSF25SMAD5-AS1PRKAA1INSL5GNG12OR1J4OCRLARAP2CLEC1AGABRR2SH3GL2PGRARHGAP45STMN1FAM3CANGPTL3RND2CDK6OSGIN2WNK4DUSP22RASSF2PLPPR4CHRNB2GABRA5DUSP15CCN2LTBRLHBITGB3BPMAPK7MDKPRKCDCD164STOML3IL2RGTFF1FGF21TNFSF13BROCK1IL2RBSCTGRK7OR1A2FGF9TNFSF4SCGB1A1COPAHIF1ALILRB1GPRC5ANRXN3SFRP5MAPKAPK5TNFRSF11AOLFM3IL10RBOR1L1SLC12A3METCD320CCR6PLAURCHRNETYRO3CD79BDLG4CMTM7CABP2APBB1IPMOB3BASIC3ANGPT4MADCAM1OLFM2ARROR2SRIRGS1RANGAP1NAE1MANFRAPH1INPP5DCILK1OXTTNFSF13CRABP1APBB1CHGBARHGAP39RASA3F2RL3PIP5K1ASTAT3RYKWNK1GRB2NTSPPP1R12BCCL8KCNIP2GFRA3ESR1PLCXD2MOB2TAFA4CREBBPTHAP12BEX1PXNRIPK2CSNK1G3RLN3RND3CXCL16CLEC11AERFECCND3GDNFNAMPTCREBL2PSG9ARHGAP36GPR173PLCXD3OR6A2CD33FBN1UTS2BACTL6AASB2CCDC3LRRC69OR1N2TNFSF14MAGI1FRS3OR1L6RASA1IGFALSOR3A1PAK5S100A11TAGAPSMAD1CSNK2A1TAAR5ADCY9CXCL8ARHGAP17RASSF4OR1I1ERBINIL4RMCCTPTESCUBE3GNAT1PPP2R5AMOB3CBMP8AAPPL2MAP2K4TNFRSF10ACLEC1BADAMTS20CSF3RINPP4BNEDD9HUNKLILRA2VEGFCTHBS4TNFRSF17OR3A2OR1L3RASGRP1KIFAP3INPP4ASHBTNFSF15BABAM2FGFBP1RASSF6DIAPH2-AS1CHRNB4KALRNIL17DLRRD1MAP2K3PKN2GNRH2PPP1R12CEPAS1GABRDLYNC3ALKCCL20HBS1LKLRC2OR7D2LEFTY2CREMCMTM5PLCB1PTPRKOR1E2LRRK2TAFA3CHRNA7AFDNFCGR1ACCL13GKAP1CLIC1AGRNNRP1CHRM4C1QTNF4DIRAS2GNALCALML5PLPP3OR2AT4CEACAM1INPP5BIL26CDC42BPBSTK25GNG5RPS6KC1PSG3ADGRA1TYROBPCAB39CMTM1ARHGAP11BPDE4ACNTNAP1ARHGAP24SARM1RGMBCACNA1ISPNTOM1MICAOR1F2PSUFUIL31RASGRF1CLEC12APSG7EPORPNOCKCNIP3GNB1VRK3GUCA1CPHB1GKN1CMTM3FGF17CNTFRTOR2AOR1D2ULK1DLC1ARHGAP20TNFSF9MOKPDPNGAB2NCR2PTPN5CLOCKPRKG1RPS6KA1CCL4VIPR2FGD1OPHN1PAK2IRS4TRAIPPLPPR1RSU1TANKCALCOCO1BEX2RASAL2NR2F1FNDC5HRASGDF1OR1B1BMP8BMOSS100A6RETNLBPMCHL1PRMT2LTKLRRC59BEX5MAPK6P2RX5RASGRP2OMPTNFRSF10DYWHAENRXN2GAB1CHRNA2CAMK1AMELXHPGDSERBB2TXNRD1MSMPPIDD1CCL15OLFML3YWHAGSYDE1AMBNTENM3OR3A3GPR85GAS6FGF18HCLS1BMP15CSF1RPROK1PRKAA2PRKCEPLEKHH3interleukin-23_humanTAFA2IGFBP5CXCL1TLE2GRAPAXLAKAP17AAIMP1APLNLMBR1LIL1RAPL1TRAF2PHLPP1RASSF10MPP1NR4A1KIF13BITKIL27IL36RNOR1P1PSG6DEKRHEBIMPA2CCL27TGFBRAP1PGLYRP1GATA3ADA2ADGRB1PPP2R5CIL21NPM1CHRNB1BGLAPGRK3CCN3OR1M1IQGAP2HNRNPKCAMLGGJA1TNFRSF11BRAP1GAPTLR3LIMK1RASA2OR7A17NET1FGF12ZP3TOM1L2TTBK1TRHDEUTS2OR1F12PBTRCNDRG2RABEP1CD226P2RX4IGBP1PILRANFAM1ARHGAP28CD4CMTM2PRKCBNFAT5IRS2CCL22CDC7DNM2CCL11STK24TRIP6GTPBP1IL23ABCRCAMK2BFGF4ARHGAP23HHIPTMED1YWHAHIL1RNAMFRFNBP1TAFA1NOD1ADORA3CERT1OR1C1FGF3STAT6CBLBTTRREG3ATRAT1DTHD1IL32CXCL5LALBAWIF1FLNBMAP2K1CXCR2CCL26PDE7BCLIC2CCL7AKT3RASSF3PTGES3INSL4PRKACBRHOCIL17BSH3GL3IFNGR1PPP3CBANXA1FLT3LGTP53BP2CCL28PSG1SCUBE1GNA14GDF3CHRNB3SOX9CDC42EP3OR2F1CD2APCRABP2OR7C1OR7E24CSNK1A1LCAMK4LPXNPECAM1KCNK10LRRC39CCL24NDRG4CABP4HLA-DRB3RIN3ADRA1AIL16RPS6KA2STK39CHL1STX2IL15OPN1LWFASLGOR5I1PDGFRBARHGAP15MAP3K21PENKRAPGEF1ARHGAP10FGF7OR1E1PLPPR3CNIH1RAC2ADIPOQLILRB2OR1L4YWHABOR3A4PDDR2ING2RND1CCKCSNK1G1SH3GL1NSMAFOR1J1LTBRIPK3SKAP2MTA1TENM4ARHGAP9CXCL6GNB5INHAARHGAP21SOX8PAK4GNL1HSH2DLRR1GRPPSG4PDE9ACXCL12TNFSF18TBXTTIMP1IGFBP6FPR1HINT1CDK2CSNK1A1NDRG3GAB4NTF3GRK4AVPSOS1SLAZPR1PITPNC1NRG2NR3C1IL9RVAC14INSL6