APBB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	15 studies	31% ± 11%	Explore
glutamatergic neuron	9 studies	38% ± 21%	Explore
GABAergic neuron	8 studies	33% ± 18%	Explore
oligodendrocyte precursor cell	8 studies	27% ± 10%	Explore
neuron	7 studies	35% ± 13%	Explore
astrocyte	5 studies	20% ± 4%	Explore
interneuron	5 studies	32% ± 16%	Explore
endothelial cell	4 studies	31% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
retinal ganglion cell	3 studies	59% ± 22%	Explore
fibroblast	3 studies	20% ± 4%	Explore
ciliated cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	31% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	17189.97	2642 / 2642	100%	136.90	705 / 705
thymus	99%	3442.35	648 / 653	99%	30.82	598 / 605
kidney	100%	3486.26	89 / 89	98%	29.57	880 / 901
prostate	100%	4400.31	244 / 245	98%	22.99	491 / 502
adrenal gland	99%	3399.90	255 / 258	95%	54.26	219 / 230
breast	100%	3027.41	457 / 459	87%	17.31	970 / 1118
skin	83%	1722.60	1503 / 1809	96%	31.87	451 / 472
ovary	100%	5979.52	180 / 180	74%	10.77	318 / 430
lung	99%	3707.20	573 / 578	67%	10.09	773 / 1155
uterus	99%	7356.94	168 / 170	50%	12.49	228 / 459
bladder	100%	4844.05	21 / 21	40%	6.23	203 / 504
pancreas	37%	669.61	122 / 328	91%	25.05	162 / 178
esophagus	77%	4475.06	1111 / 1445	43%	5.31	78 / 183
intestine	86%	4622.23	834 / 966	32%	4.23	168 / 527
stomach	68%	2398.17	243 / 359	40%	5.63	115 / 286
eye	0%	0	0 / 0	100%	36.14	80 / 80
blood vessel	100%	5146.60	1333 / 1335	0%	0	0 / 0
muscle	99%	3147.31	791 / 803	0%	0	0 / 0
spleen	98%	2505.03	237 / 241	0%	0	0 / 0
adipose	98%	2818.09	1179 / 1204	0%	0	0 / 0
heart	96%	4706.68	825 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	13.84	24 / 29
liver	0%	8.17	1 / 226	50%	6.56	205 / 406
tonsil	0%	0	0 / 0	36%	4.89	16 / 45
peripheral blood	19%	373.40	179 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0006939	Biological process	smooth muscle contraction
GO_1902807	Biological process	negative regulation of cell cycle G1/S phase transition
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0007165	Biological process	signal transduction
GO_0006974	Biological process	DNA damage response
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0007409	Biological process	axonogenesis
GO_0050714	Biological process	positive regulation of protein secretion
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0006915	Biological process	apoptotic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005886	Cellular component	plasma membrane
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045202	Cellular component	synapse
GO_0030426	Cellular component	growth cone
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0005634	Cellular component	nucleus
GO_0008134	Molecular function	transcription factor binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0070064	Molecular function	proline-rich region binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0050750	Molecular function	low-density lipoprotein particle receptor binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	APBB1
Protein name	Adaptor protein FE65a2 Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) Amyloid beta precursor protein binding family B member 1
Synonyms	RIR FE65
Description	FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions . Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain . Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis . May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 . Required for histone H4 acetylation at double-strand breaks (DSBs) . Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity . Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 . Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) . Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment . .
Accessions	ENST00000609360.6 [O00213-1] ENST00000608655.6 [O00213-5] ENST00000299402.10 [O00213-2] ENST00000529890.5 ENST00000530885.5 [O00213-3] ENST00000608394.5 [O00213-4] V9GY97 ENST00000608645.5 [O00213-4] ENST00000529519.5 ENST00000609331.5 [O00213-6] A0A075B7G8 ENST00000608435.5 ENST00000608704.5 [O00213-4] ENST00000311051.7 [O00213-2] V9GYR7 O00213 Q8TEY4 ENST00000532020.2 V9GYD5

APBB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review