GO_0000122 | OmnibusX

negative regulation of transcription by RNA polymerase II

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	BMP2-ACVR2B+BMPR1A	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
2	BMP2-ACVR2B+BMPR1B	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
3	BMP4-ACVR2B+BMPR1A	BMP4_HUMAN -	Ligand-Receptor	Signaling by BMP
4	BMP4-ACVR2B+BMPR1B	BMP4_HUMAN -	Ligand-Receptor	Signaling by BMP
5	BMP6-ACVR1+ACVR2B	BMP6_HUMAN -	Ligand-Receptor	Signaling by BMP
6	BMP6-ACVR2B+BMPR1A	BMP6_HUMAN -	Ligand-Receptor	Signaling by BMP
7	BMP6-ACVR2B+BMPR1B	BMP6_HUMAN -	Ligand-Receptor	Signaling by BMP
8	DLL4-NOTCH1	DLL4_HUMAN - NOTC1_HUMAN	Ligand-Receptor	Signaling by Notch
9	DLL4-NOTCH2	DLL4_HUMAN - NOTC2_HUMAN	Ligand-Receptor	Signaling by Notch
10	DLL4-NOTCH3	DLL4_HUMAN - NOTC3_HUMAN	Ligand-Receptor	Signaling by Notch
11	DLL4-NOTCH4	DLL4_HUMAN - NOTC4_HUMAN	Ligand-Receptor	Signaling by Notch
12	EDN1-EDNRB	EDN1_HUMAN - EDNRB_HUMAN	Ligand-Receptor	Signaling by Endothelin
13	NODAL-ACVR1B+ACVR2B+CFC1	NODAL_HUMAN -	Ligand-Receptor	Signaling by NODAL
14	NODAL-ACVR1B+ACVR2B+TDGF1	NODAL_HUMAN -	Ligand-Receptor	Signaling by NODAL
15	NODAL-ACVR1C+ACVR2B+CFC1	NODAL_HUMAN -	Ligand-Receptor	Signaling by NODAL
16	NODAL-ACVR1C+ACVR2B+TDGF1	NODAL_HUMAN -	Ligand-Receptor	Signaling by NODAL
17	SHH-BOC+PTCH1	SHH_HUMAN -	Ligand-Receptor	Signaling by Sonic hedgehog
18	SHH-CDON+PTCH1	SHH_HUMAN -	Ligand-Receptor	Signaling by Sonic hedgehog
19	SHH-GAS1+PTCH1	SHH_HUMAN -	Ligand-Receptor	Signaling by Sonic hedgehog

II. Literature review

Name	negative regulation of transcription by RNA polymerase II
ID	GO_0000122
collection_id	Biological process
Alternative ID	GO:0010553, GO:0045816
Exact synonym	down regulation of transcription from RNA polymerase II promoter, down-regulation of transcription from RNA polymerase II promoter, downregulation of transcription from RNA polymerase II promoter, inhibition of transcription from RNA polymerase II promoter, negative regulation of transcription from Pol II promoter, negative regulation of transcription from RNA polymerase II promoter
Description	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
Related synonym	down regulation of global transcription from RNA polymerase II promoter, down-regulation of global transcription from RNA polymerase II promoter, downregulation of global transcription from RNA polymerase II promoter, inhibition of global transcription from RNA polymerase II promoter, negative regulation of gene-specific transcription from RNA polymerase II promoter, negative regulation of global transcription from Pol II promoter, negative regulation of transcription from RNA polymerase II promoter, global
External URL
Genes	PER2 MAGEA10 PSMD10 SOX10 PIAS1 FOXO3 ZNF268 EID1 THRA PRDM13 LMCD1 prc2_human-8 JUND GATA2 LEFTY1 DACT1 AEBP2 NR2E1 HCFC1 MEF2A ZNF354C mxd1-mlx_human TBX3 ZNF131 atf3_human-1 RARB IFI27 ELK3 ZNF536 TRIM27 PROP1 ATXN1L DMAP1 MNX1 YBX3 NR1I2 foxo3-myc_human CTCF NR2C2 HOXB4 ZNF140 IRF3 RIPPLY1 ZNF202 ZBTB5 FAM220A HAMP MAGEC3 SOX18 RORC NOTCH2 MACROH2A2 bach1-maf_human ZNF296 max-mga_human DCAF1 EFNA1 ACVR2B SP100 ZNF219 ETV5 MYOCD SUV39H2 RPS14 KDM1A CALR E4F1 MAGEC1 RTF1 CEBPB NR1H3 CCND1 POU4F2 TSG101 MAEL GPS2 PTCH1 SNAI1 DNAJC17 RFC1 ZBTB45 APBB2 LEP MITF IGF2 GATAD2A FOXE1 CD36 JPH2 ID4 DUSP26 NDN E2F8 PDE2A NR0B1 SMURF2 ZNF568 NSD1 prc2_human-5 MAZ MAGED2 MAFF KLF8 SPDEF STAT1 MAP2K5 DPF2 TAL1 ATN1 TGIF1 FOXQ1 KLF16 TAF9B KLF12 ZNF174 ZFP36 E2F7 TGIF2 LRRFIP1 SDR16C5 CGGBP1 NKX6-3 CCNE1 SPEN MXD4 ZEB2 SP2 bach2_mafg_human PATZ1 ARID5B PHF6 RPL23 MYOZ2 SREBF1 NIF3L1 OLIG2 MAGEA13P NFX1 CC2D1B ZHX2 GLIS2 PSEN1 JAZF1 TBX22 MSX1 FOXP4 MAGEB16 GLI3 AKIRIN2 TMPRSS6 SKOR2 PRKN HMGB1 FOXP3 CNOT2 pcr2_human SARS1 E2F6 RBBP4 TAF1 YEATS2 SAMD1 ZBTB16 TLE5 GATA5 KLF11 MACROH2A1 ZNF254 ZNF85 NELFE ARID4A MAD2L2 OSR2 cmyc_bin1_human DLL4 ZNF750 NR2E3 ISL1 SMAD5 STRAP prc2_human-10 ZNF91 OSR1 JARID2 VEGFA CRYM NFKB1 MBD3 NRIP1 NR2C1 SAP30L prc2_human-22 NR1I3 prc2_human-9 KHDRBS1 ETV7 HES5 TCF21 SMAD3 H1-4 RIPPLY3 MECP2 TRPV1 ZBTB2 MTA2 TBX2 ZNF668 MEIS2 HSBP1 ZBED6 CNBP ZBTB7B PKIG BCL6B MXI1 PEG3 SALL4 NR2F2 MAGEB17 NR1D2 OGT mxd3-max_human NR1H2 TPR FST ZNF239 GTF2IRD1 ING1 BCL6 NOP53 HMG20A ZNF366 CBFB nc2_human sin3a_esc_human-1 SEMA4D ATF3 prc2_human ZNF93 prc2_human-7 ESR2 DNMT3B TAF3 GATA4 TADA3 MAFK URI1 GABPA MAGEB5 MLIP gem-hoxd10_human IRF2 MAGEA12 RUNX3 HESX1 SAP30 PHF19 ZBTB49 INSM2 FNIP2 THAP7 OLIG3 HDGF MAGEA3 LARP7 MAFB NR1D1 CIR1 VHL EHMT1 PCGF2 mad1-max_human FOXR1 MAGEB2 HSPA1A CEBPA PCGF6 ID3 WDR5 PRDM16 MBD3L2B CUL3 MAFG HMGB2 FOXG1 UXT ZNF217 DICER1 SKIL RIPPLY2 FOXP1 PROX1 MDM4 LYAR TENM2 FOSB ATF7IP N4BP2L2 CITED2 IRF2BPL WFS1 ZKSCAN3 MSX2 FAM220BP HEYL DDIT3 EED SATB2 TAF7 UBE2D1 BMP6 WWC1 PRRX1 MTDH ZNF345 PURB TRIB3 NANOG FLYWCH1 WWC3 FGFR1 MYB UBE2I ZNF175 PKIA SCRT1 CDX4 TWIST1 SAP130 IRF7 ETS2 mnt-mlx_human MXD3 DLG1 ZMYND8 HEY2 CREB3L1 HDAC4 DNAJA3 ZBTB1 SMYD2 MTA3 SALL1 ID2 YWHAZ RFX5 MAGEF1 PPARG HES2 EDNRB TFEC atf2-fosl2_human-1 TGFB1 MBD3L4 SNW1 EHMT2 prc2_human-11 LIN37 FOXA1 ZBTB33 CBX2 HES6 ZNF746 MBD2 MYPOP SATB1 BATF3 ZNF572 COPS2 RLIM MAGEA6 TP53 CHD3 MAGEA11 VSX2 MYT1L HOXA7 MIER3 sin3b_human-2 EP300 CPEB3 NACC2 MAGEA9 EZR TBX20 bach1-mafk_human p50-p50_human SOX12 prc2_human-20 PHF12 HEXIM2 EPC1 SAMD11 H1-3 BACH2 LEF1 prc2_human-24 SSX1 ELANE ZNF177 ALX1 SINHCAF NOTCH1 HDAC5 mxd4-mlx_human HOXB8 MBD3L5 KDM5A MEF2C URS000024A59E_9606 ZNF512B LDB2 AURKB NEUROG3 ZNF274 bpha1f-bpha2f ETV6 NUPR2 PCNA H1-2 YBX1 WNT10B SDCBP HEXIM1 NOG TRIM33 RNF2 SIN3A RB1 p50-p52_human NEDD4 ZNF354B ASCL2 SCRT2 TCF7L2 ZBED2 bach2_mafk_human HOXD9 TRPS1 MAGED1 ZBTB6 DDX20 ZBTB21 ZNF8 ZBTB18 prc2_human-4 SFN NCK2 WDTC1 CHD4 BHLHE40 LCOR SOX2 CDC73 GFI1 BCOR KMT5A SAMD7 TRIM28 NFE2L3 EPO prc2_human-25 SNAI2 H1-5 TAGLN3 ZFPM1 OTUD7B DLX2 NFATC4 EID2 THRB SIRT6 RBM10 PLK3 REST NR4A2 CUX2 NCOR1 PTPN2 ETV3 NKX3-2 CBX8 MIER1 MMP12 ZNF281 HES1 NCOR2 ZBTB20 SIN3B CBX4 LMO1 GZF1 SKOR1 MED1 DDX5 MEPCE FEZF2 BCORL1 MAGEB10 WWTR1 HEY1 PARP1 SMARCA2 ATXN1 ZBTB37 SMARCA4 SHH ZBTB4 TGIF2LX TBX21 p52-p52_human NKX6-1 CDK6 MAGEB1 chop-cebpa_human RARA DUSP22 SLA2 foxo3:14-3-3 zeta_human HOXA2 AJUBA prc2_human-1 ZNF469 POU1F1 PDX1 SUPT4H1 SARNP DNMT1 FOXM1 KANK2 TET1 MYC NR1H4 HAND1 ZNF304 BPTF prc2_human-3 SOX4 SOX3 FGF9 SCGB1A1 SUZ12 SIRT1 ZBTB10 POU6F1 MAGEB4 TCERG1 FNIP1 FEZF1 DNMT3L MBD3L2 ZNF134 OVOL1 PRMT6 CRY2 TRIM37 SREBF2 PRDM5 YAP1 MORC3 AEBP1 PRDM12 AR RREB1 LINC-PINT PRDM14 HSF1 ZNF589 APBB1 FLCN ZBTB26 ATF2 STAT3 HELT NOTCH4 GSC IRX1 CTR9 ESR1 MAGEE1 GFI1B CREBBP MAGED4 PPARD NFATC2 BMP2 ZNF136 FOXD3 TBX18 CCND3 IRX4 USP2 DAB2IP FHL2 RYBP FOXJ1 ZHX1 FRK ASCL3 USP9X BARX2 MXD1 prc2_human-13 TCFL5 MLX bach1-mafb_human TLE6 MLXIPL DMRT1 SNCA MAGEA8 SPI1 TCP10L RUNX1 TFAP2A ZNF224 TLE4 ZEB1 PLK1 MAGEA4 ZC3H8 EOMES BHLHE41 mnt-max_human ZBTB39 DNAJB4 DKK1 ANKRD2 NCOA2 HCFC2 TDG NKAP prc2_human-15 MCPH1 ZNF431 HDAC8 TXNIP HDAC2 TCF23 MAGEB18 NR2F6 IL4 CREM SKI GADD45A DMBX1 HES7 TP63 ELK4 MAGEA1 RPL10 BMP4 PER3 IRX3 ZFHX3 ZNF608 NOTCH3 SIRT7 ZNF148 HIC1 CBFA2T2 HDAC3 SP5 NFIL3 SUPT5H CBX6 JUN PCBP3 TSC22D4 ZBTB17 DNAJB1 POU5F1 DRAP1 BCL11A ZMYM5 prc2_human-19 men1_jund_human gem-hoxc9_human SFPQ DLX4 SUFU SP3 CBX5 VDR PAX5 KCNIP3 HOXD8 SOX11 bach2_maf_human TNFSF11 PCGF1 MBD3L1 TRPV4 PHB1 KLF2 ZNF263 FOXK1 EGR1 CTBP1 prc2_human-16 KLF10 MAGEB6 HNRNPA2B1 TNF SGF29 SMO TRO C1QBP ZNF133 KLF4 VAX1 TXN HIVEP1 SNAI3 NODAL INSM1 HHEX CAV1 ZBTB8A BIN1 ERF HSF4 sin3a_human-2 ZNF141 NR2F1 ZFP90 ESX1 HINFP mxd4-max_human bach2_mafb_human KLF5 NCOA5 RITA1 NR6A1 ZBTB34 ID1 IRF2BP1 MOSPD1 GATA1 BACH1 prc2_human-17 NACC1 MDM2 BMI1 HNRNPU NKX2-1 SMAD4 SIRT2 prc2_human-2 MAGEB3 HCLS1 DR1 mxi1-max_human ARID4B DAB2 PHF14 RARG WT1 LOXL2 FERD3L MAGEE2 SUV39H1 HOXB13 ZBTB32 FOXF1 ZNF692 ZBTB7A WWC2 HDAC1 PHF21A prc2_human-6 IFNG ZBTB14 EN1 AASS TFAP2B prc2_human-23 MSC DLX1 GATA3 MAX HJV PARP9 SHOX2 KLF3 chop-cebpb_human HNF1B EZH2 RXRA KAT14 VPS72 IFI16 VAX2 NR0B2 CRY1 CELA1 KAT2A SIM2 HDAC10 HIC2 THAP11 IL33 TBX6 PLAGL1 NOC2L FOXH1 UBE2D3 TCF3 HOXC8 TFCP2L1 LMO4 CXXC5 NCK1 BTG2 PAF1 bach1-mafg_human FOXS1 prc2_human-12 bach2_human-1 FOXC1 PPARA CBX7 IGBP1 TRIM29 PAX6 UHRF1 MBD3L3 LDB1 RELA PURA TRAF6 TBL1X WWP2 PRDM2 JDP2 ARX DEAF1 HMGA2 SOX15 HDAC7 HIPK2 PRDM1 POU4F1 bach1-maff_human MZF1 ZNF350 MAF SUDS3 MED25 MBIP MIER2 PPM1A NSD2 STAT6 ATF4 PPP1R13L RBBP7 PAWR BRMS1 BEND3 NKX6-2 CIITA MYOZ1 MDFI prc2_human-18 ENO1 HDAC9 FOXP2 IRF8 CUX1 NRARP TBL1XR1 FOXL2 YY1 PRDM6 OTP EZH1 GLI2 bach2_maff_human HOXB3 RIF1 NR4A3 prc2_human-21 IMPACT NFIC USP3 SOX21 MAGEL2 TGIF2LY FOXC2 ZBTB46 ZNF653 MNT SOX9 TBX15 RALY RBL1 SORBS3 GATA6 FOXK2 POLE3 NKX2-5 SOX30 IRF2BP2 ZNF675 CDX2 IKZF5 SMAD7 TFAP2C ZFPM2 KAT5 MEN1 e2f6-dp1_human prc2_human-14 THAP5 SRY PIAS4 NFIX FASLG KDM2B ASCL1 HMBOX1 PPID ZBTB42 SOX13 NIPBL ZGLP1 ORC2 MAGEA2 PER1 IRX2 METTL13 ING2 DACH1 GATAD2B FOXO1 SQSTM1 E2F1 MTA1 OVOL2 ZBTB25 SIX1 HOPX MAGEB6B CNOT1 SOX8 ZNF205 CHD8 ZBTB12 EDN1 NSMCE3 MAGEC2 FBP1 CTNNB1 TBXT MAGEH1 KLF7 PARP15 SOX14 CDK2 SOX1 ARID5A BRMS1L KAT2B NPAS1 NACA NKX3-1 HMX1 vhl-elobc_human GLIS3 RBPJ NRIP2 TCF25 THAP1 CTBP2 GLIS1 FGFR2 DNMT3A ZGPAT NR3C1 NFATC3 PIAS3