Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 12 studies | 40% ± 19% | |
oligodendrocyte precursor cell | 12 studies | 32% ± 16% | |
fibroblast | 10 studies | 26% ± 13% | |
endothelial cell | 8 studies | 25% ± 9% | |
adipocyte | 8 studies | 28% ± 14% | |
oligodendrocyte | 8 studies | 34% ± 10% | |
hepatocyte | 5 studies | 43% ± 27% | |
pericyte | 5 studies | 27% ± 14% | |
cardiac muscle cell | 4 studies | 19% ± 3% | |
GABAergic neuron | 3 studies | 18% ± 2% | |
glial cell | 3 studies | 24% ± 2% | |
connective tissue cell | 3 studies | 22% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 24% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2055.53 | 245 / 245 | 100% | 15.33 | 501 / 502 |
thymus | 99% | 1597.52 | 646 / 653 | 91% | 7.71 | 552 / 605 |
skin | 94% | 1353.09 | 1694 / 1809 | 92% | 14.91 | 435 / 472 |
lung | 99% | 2564.34 | 575 / 578 | 86% | 13.12 | 997 / 1155 |
kidney | 97% | 1146.22 | 86 / 89 | 89% | 10.49 | 798 / 901 |
pancreas | 91% | 1977.15 | 298 / 328 | 91% | 7.07 | 162 / 178 |
liver | 97% | 2458.59 | 219 / 226 | 82% | 19.76 | 334 / 406 |
adrenal gland | 97% | 1091.85 | 250 / 258 | 81% | 6.30 | 186 / 230 |
breast | 100% | 3213.30 | 457 / 459 | 73% | 5.79 | 818 / 1118 |
esophagus | 97% | 2716.39 | 1401 / 1445 | 75% | 6.48 | 138 / 183 |
uterus | 99% | 3771.78 | 169 / 170 | 67% | 6.74 | 307 / 459 |
brain | 56% | 498.67 | 1467 / 2642 | 100% | 32.97 | 703 / 705 |
bladder | 95% | 2543.86 | 20 / 21 | 59% | 5.78 | 298 / 504 |
ovary | 100% | 7568.93 | 180 / 180 | 39% | 2.47 | 168 / 430 |
stomach | 94% | 2014.00 | 338 / 359 | 42% | 2.49 | 120 / 286 |
intestine | 94% | 1647.94 | 905 / 966 | 41% | 2.48 | 216 / 527 |
blood vessel | 100% | 3404.57 | 1335 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 3163.68 | 1202 / 1204 | 0% | 0 | 0 / 0 |
heart | 89% | 1400.01 | 770 / 861 | 0% | 0 | 0 / 0 |
muscle | 81% | 1160.80 | 648 / 803 | 0% | 0 | 0 / 0 |
spleen | 74% | 760.46 | 178 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 74% | 7.22 | 59 / 80 |
tonsil | 0% | 0 | 0 / 0 | 64% | 6.03 | 29 / 45 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.60 | 3 / 29 |
peripheral blood | 2% | 13.50 | 15 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006554 | Biological process | lysine catabolic process |
GO_0033512 | Biological process | L-lysine catabolic process to acetyl-CoA via saccharopine |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0019878 | Biological process | lysine biosynthetic process via aminoadipic acid |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0005634 | Cellular component | nucleus |
GO_0004753 | Molecular function | saccharopine dehydrogenase activity |
GO_0047130 | Molecular function | saccharopine dehydrogenase (NADP+, L-lysine-forming) activity |
GO_0047131 | Molecular function | saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity |
GO_0004754 | Molecular function | saccharopine dehydrogenase (NAD+, L-lysine-forming) activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0042393 | Molecular function | histone binding |
Gene name | AASS |
Protein name | Aminoadipate-semialdehyde synthase Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)] |
Synonyms | tcag7.61 hCG_33410 |
Description | FUNCTION: Bifunctional enzyme that catalyzes the first two steps in lysine degradation. . |
Accessions | ENST00000417368.7 A0A7P0T8W7 ENST00000681626.1 ENST00000679659.1 A0A7P0Z4M3 ENST00000680080.1 A4D0W4 ENST00000358954.6 ENST00000679511.1 ENST00000679764.1 A0A7P0Z402 A0A7P0TAY5 A0A7P0TBD2 ENST00000681907.1 ENST00000393376.5 A0A7P0T9N4 A0A7P0TA62 F8WE53 ENST00000681213.1 ENST00000473553.5 A0A7P0TB07 A0A7P0TA09 ENST00000681511.1 F8WAH1 ENST00000679864.1 ENST00000679579.1 Q9UDR5 A0A7P0T834 ENST00000681314.1 ENST00000681387.1 ENST00000679847.1 ENST00000679721.1 ENST00000431170.5 ENST00000681434.1 ENST00000681318.1 A0A7P0Z428 ENST00000679419.1 |