Molecular function

GO:0001106

transcription co-repressor activity

A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

RNA polymerase II transcription co-repressor activity, RNA polymerase II transcription corepressor activity

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.