HDAC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006366Biological processtranscription by RNA polymerase II
GO_0001701Biological processin utero embryonic development
GO_0071498Biological processcellular response to fluid shear stress
GO_0061436Biological processestablishment of skin barrier
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0006476Biological processprotein deacetylation
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0040014Biological processregulation of multicellular organism growth
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_2000726Biological processnegative regulation of cardiac muscle cell differentiation
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0043066Biological processnegative regulation of apoptotic process
GO_1903575Biological processcornified envelope assembly
GO_0051225Biological processspindle assembly
GO_0007346Biological processregulation of mitotic cell cycle
GO_0046329Biological processnegative regulation of JNK cascade
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0040029Biological processepigenetic regulation of gene expression
GO_0032008Biological processpositive regulation of TOR signaling
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0031647Biological processregulation of protein stability
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0072686Cellular componentmitotic spindle
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0017053Cellular componenttranscription repressor complex
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0160008Molecular functionprotein decrotonylase activity
GO_0160010Molecular functionprotein de-2-hydroxyisobutyrylase activity
GO_0031490Molecular functionchromatin DNA binding
GO_0160009Molecular functionhistone decrotonylase activity
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding
GO_0051059Molecular functionNF-kappaB binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHDAC3
Protein nameHistone deacetylase 3 (EC 3.5.1.98)
Histone deacetylase 3
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Synonyms
DescriptionFUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression . Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress . Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as a deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3 . Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding . In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response . In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively . Catalyzes decrotonylation of MAPRE1/EB1 . .

AccessionsENST00000523088.5
O15379
E7ESJ6
B5MGH4
ENST00000519474.5
E7EW19
ENST00000305264.8 [O15379-1]