GO_0043066 | OmnibusX

negative regulation of apoptotic process

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	AKR1B1-PTGFR	- PF2R_HUMAN	Ligand-Receptor	Signaling by Prostaglandin
2	ANGPT1-TEK	ANGP1_HUMAN - TIE2_HUMAN	Ligand-Receptor	Signaling by Angiopoietin
3	ANGPT4-TEK	ANGP4_HUMAN - TIE2_HUMAN	Ligand-Receptor	Signaling by Angiopoietin
4	GAS6-AXL	GAS6_HUMAN - UFO_HUMAN	Ligand-Receptor	Signaling by Growth arrest
5	IGF1-GPC3+IGF1R	IGF1_HUMAN -	Ligand-Receptor	Signaling by Insulin-like growth factor
6	IGF1-IGF1R	IGF1_HUMAN - IGF1R_HUMAN	Ligand-Receptor	Signaling by Insulin-like growth factor
7	IHH-HHIP	IHH_HUMAN - HHIP_HUMAN	Ligand-Ligand	Signaling by Indian hedgehog
8	IL2-IL2RA+IL2RB+IL2RG	IL2_HUMAN -	Ligand-Receptor	Signaling by Interleukin
9	IL2-IL2RB+IL2RG	IL2_HUMAN -	Ligand-Receptor	Signaling by Interleukin
10	IL6-IL6R+IL6ST	IL6_HUMAN -	Ligand-Receptor	Signaling by Interleukin
11	INSL3-RXFP2	INSL3_HUMAN - RXFP2_HUMAN	Ligand-Receptor	Signaling by Insulin-like precursor
12	SHH-HHIP	SHH_HUMAN - HHIP_HUMAN	Ligand-Ligand	Signaling by Sonic hedgehog
13	TNFSF18-TNFRSF18	TNF18_HUMAN - TNR18_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
14	WNT1-SFRP1	WNT1_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
15	WNT5A-SFRP1	WNT5A_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
16	WNT7A-SFRP1	WNT7A_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition

II. Literature review

Name	negative regulation of apoptotic process
ID	GO_0043066
collection_id	Biological process
Alternative ID	GO:0006916
Exact synonym	anti-apoptosis, down regulation of apoptosis, down-regulation of apoptosis, downregulation of apoptosis
Description	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
Related synonym	apoptosis inhibitor activity, pro-survival
Comment	This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
External URL
Genes	PSMD10 SOX10 BAG3 PIAS1 ZNF268 SH3RF2 SERPINB2 CASP2 TPT1 GFER PRAME NR2E1 ANKLE2 TBX3 MTOR RICTOR SPHK1 HSPD1 PROP1 MT-RNR2 BRAF URS0000D5ABCC_9606 THBS1 BECN1 STIL NOL3 DNAJA1 NKX2-6 NOTCH2 BCL2L1 PRAMEF13 HSPA5 HTATIP2 MAPK8 URS00008121A2_9606 PRDM9 DPEP1 FMN2 VTCN1 MAEL PRAMEF10 BNIP1 APBB2 PTMA LEP MITF NCKAP1L TWIST2 BCL3 ERBB3 PRAMEF25 RHBDD1 GREM1 SRC CCN1 TMEM14A PRKCZ SH3RF1 TAF9B IER3 MICAL1 ARAF GCG PPT1 URS00022712BD_9606 SCX URS00003B7674_9606 ERBB4 PSEN1 PRAMEF17 MSX1 GLI3 SOCS3 ASNS XIAP AURKA FABP1 CD38 il-27r_human TNFRSF6B MIF FLT4 PRAMEF6 LIMS2 MPO BAG6 PRAMEF19 RAF1 SMAD5 FAS OSR1 VEGFA NFKB1 MAP4K4 CFL1 AVEN survivin_human SMAD3 BIRC7 HSP90AB1 RNF144B RIPK1 ADORA1 LTF BNIP3 DHRS2 PIM2 MIEN1 FXN PRELID1 TENT5B PRAMEF27 SEMA4D INTS1 PTGFR NUGGC PRR5 CDK1 DNAJC3 PSMG2 ARF4 IL7 vegfa_human-1 HSPB1 DAD1 SFRP1 ITCH FLNA VHL BCL2L10 IL6ST NIBAN2 HIPK3 HSPA1A MGMT NAA16 BCL2 PRAMEF18 GLO1 FCMR YME1L1 MDM4 PDCD4 NUAK2 CITED2 WFS1 MSX2 UNG MTDH MAD2L1 GOLPH3 CAT PRKCI NPY5R PCID2 PTK2 CCND2 TWIST1 ANXA5 HSPB6 DNAJA3 PHB2 EVI2B TRIAP1 RPS6KA3 NUPR1 YWHAZ EDNRB HGF IL31RA EGFR HSP90B1 KRT18 SON CFLAR CIB1 IFI6 NDUFAF4 DSTYK FANK1 ANGPT1 FIGNL1 BCL2L2 POU3F3 PKHD1 CBL TP53 AQP1 AKT1 TSC22D1 URS0000D5BEC8_9606 BAG4 TFRC OGG1 HMGN5 FOXE3 DAPK1 SERPINB9 PROC RPS6KB1 PAGE4 UFM1 CLN3 LEF1 C8orf17 PLAC8 PDCD10 PRLR IGF1R TMIGD1 PTK2B PRDX3 ERCC5 TAF9 BCL2A1 HIP1R SIN3A EGR3 BIRC6 PIM3 CRIPTO RPS6 IGF1 PRAMEF33 TNFRSF18 AREL1 ARHGDIA CLEC5A AZU1 OPN3 ZFAND6 CDC73 GRK5 URS000081217E_9606 CBS CREB1 AKR1B1 PLK3 HIGD2A PRAMEF4 URS0000812191_9606 NKX3-2 TEK ANXA4 CBX4 MMP9 FATE1 HSPA1B MED1 AIPL1 CLDN7 ATF5 PRAMEF20 RNF157 AHI1 KLHL20 PRKAA1 LACRT HTR2B BFAR SHH TJP1 CDKN1A XBP1 STK40 HIGD1A MRE11 ARL6IP1 CD28 RGN URS0000D59BC3_9606 PRNP FSTL1 MYC NR1H4 IL2RB PRAP1 URS0000D5B7E7_9606 CX3CL1 SLC9A1 SIRT1 NAA15 URS000014D9C1_9606 PLAUR URS000006FDD4_9606 IFIT3 il15-il15r_human PPIF FFAR4 TNFAIP8 ANGPT4 GSK3B URS00002C6949_9606 PRAMEF22 OPA1 SIAH2 PRAMEF12 CEACAM5 ERFE MLST8 GDNF FHL2 PALB2 URS000039ED8D_9606 WNT7A CRYAB BAG1 PRAMEF26 RASA1 FKBP8 TMBIM4 ZNF16 HYPK PRAMEF15 SNCA ADAMTS20 PRAMEF2 URS0000170CF4_9606 URS0000729A58_9606 URS0000D5DAAD_9606 UFL1 CD27 MNAT1 TFAP2A UBE2Z SIX4 NAT8B BABAM2 PLK1 MAGEA4 DKK1 BARD1 BIRC2 WDR73 URS000081210B_9606 HDAC2 NAIP COMP IL4 SMG9 PRAMEF7 RPL10 CD74 PROK2 DDAH2 HDAC3 DYRK3 PRAMEF9 COPS5 BIRC8 AKR1A1 PLK2 CRYAA IHH GSTP1 SMO IL10 PDPN RPS6KA1 PRDX5 VDAC1 SHC1 PAK2 mtorc2_human UBE2B RXFP2 NAA35 CIAPIN1 HAX1 SMAD6 SOCS2 LTK BIRC5 TNFRSF10D PA2G4 BNIP3L TEX11 GATA1 NAA38 ERBB2 PIDD1 MDM2 MAPK8IP3 WNK3 HPN GAS6 KIF14 CSF1R TAX1BP1 PRKAA2 MALT1 TSLP DAB2 NNT WT1 AXL PRAMEF5 MYO18A HDAC1 PAX7 TFAP2B CCNG1 ANGPTL4 NPM1 HCK NTSR1 PRDX2 NUP62 RPS3A HNRNPK SYCP2 NTRK1 CTSH URS000031E6A1_9606 LHX4 BIRC3 API5 RELA TCIM APIP PRAMEF14 NME2 HMGA2 FGF4 POU4F1 MCL1 HHIP IL2 MAPKAP1 HSPA9 ZNF830 LHX3 TXNDC5 WNT1 GHRL CHST11 LRP2 PRAMEF1 FAIM2 BNIP2 SUPV3L1 PHIP ANXA1 EIF2AK2 PTMS SOX9 DDB1 AGO4 WNT5A CARD14 GATA6 CTNS NKX2-5 ASIC2 CAPN3 ACTC1 PRKDC CD40LG ASCL1 DDX3X SLC40A1 ARHGAP10 MYDGF CD44 DDR2 PRAMEF8 GCLC KHDC3L PIM1 FOXO1 CAMK1D PDE3A ATAD3A SPRY2 PAX2 PRAMEF11 SOX8 TMBIM6 NQO1 PIK3R1 INSL3 IL6 TNFSF18 CTNNB1 TIMP1 EEF2K DDRGK1 USP47 AVP HSPB2