I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hematopoietic precursor cell | 3 studies | 50% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hematopoietic precursor cell | 3 studies | 50% ± 7% |
Insufficient scRNA-seq data for expression of MPO at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 96% | 128.40 | 2527 / 2642 | 18% | 0.34 | 127 / 705 |
| lung | 99% | 1256.92 | 572 / 578 | 8% | 1.29 | 88 / 1155 |
| spleen | 100% | 3304.39 | 240 / 241 | 0% | 0 | 0 / 0 |
| muscle | 84% | 97.54 | 675 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 84% | 7910.03 | 776 / 929 | 0% | 0 | 0 / 0 |
| liver | 64% | 146.63 | 145 / 226 | 2% | 0.05 | 7 / 406 |
| breast | 61% | 56.86 | 282 / 459 | 3% | 0.07 | 35 / 1118 |
| thymus | 56% | 52.01 | 367 / 653 | 7% | 0.25 | 43 / 605 |
| heart | 59% | 78.78 | 510 / 861 | 0% | 0 | 0 / 0 |
| adipose | 54% | 60.01 | 649 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 49% | 28.04 | 120 / 245 | 0% | 0 | 0 / 502 |
| adrenal gland | 28% | 19.44 | 73 / 258 | 20% | 0.57 | 46 / 230 |
| kidney | 37% | 24.66 | 33 / 89 | 6% | 0.21 | 50 / 901 |
| bladder | 38% | 19.00 | 8 / 21 | 4% | 0.07 | 20 / 504 |
| blood vessel | 38% | 27.61 | 503 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 34% | 18.93 | 332 / 966 | 3% | 0.05 | 14 / 527 |
| esophagus | 31% | 23.01 | 450 / 1445 | 2% | 0.04 | 4 / 183 |
| uterus | 20% | 12.89 | 34 / 170 | 7% | 0.34 | 32 / 459 |
| stomach | 19% | 10.45 | 70 / 359 | 5% | 0.21 | 15 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 0.42 | 7 / 29 |
| ovary | 13% | 8.91 | 23 / 180 | 7% | 0.14 | 30 / 430 |
| pancreas | 8% | 5.25 | 27 / 328 | 8% | 0.15 | 15 / 178 |
| skin | 5% | 2.23 | 86 / 1809 | 6% | 0.22 | 26 / 472 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.10 | 6 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.15 | 2 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050832 | Biological process | defense response to fungus |
| GO_1990268 | Biological process | response to gold nanoparticle |
| GO_0002679 | Biological process | respiratory burst involved in defense response |
| GO_0042744 | Biological process | hydrogen peroxide catabolic process |
| GO_0002149 | Biological process | hypochlorous acid biosynthetic process |
| GO_0034374 | Biological process | low-density lipoprotein particle remodeling |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0001878 | Biological process | response to yeast |
| GO_0009612 | Biological process | response to mechanical stimulus |
| GO_0019430 | Biological process | removal of superoxide radicals |
| GO_0032094 | Biological process | response to food |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0006952 | Biological process | defense response |
| GO_0035578 | Cellular component | azurophil granule lumen |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005764 | Cellular component | lysosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0042582 | Cellular component | azurophil granule |
| GO_0097013 | Cellular component | phagocytic vesicle lumen |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030141 | Cellular component | secretory granule |
| GO_0005634 | Cellular component | nucleus |
| GO_0004601 | Molecular function | peroxidase activity |
| GO_0008201 | Molecular function | heparin binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MPO |
| Protein name | Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] Myeloperoxidase Peroxidase (Myeloperoxidase) (EC 1.11.1.7) |
| Synonyms | |
| Description | FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity . Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage . . |
| Accessions | J3QSF7 P05164 ENST00000699291.1 ENST00000577220.1 ENST00000225275.4 [P05164-1] A0A8V8TPE5 Q16771 |
