ATF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009791Biological processpost-embryonic development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0046605Biological processregulation of centrosome cycle
GO_0035264Biological processmulticellular organism growth
GO_1902750Biological processnegative regulation of cell cycle G2/M phase transition
GO_0007623Biological processcircadian rhythm
GO_0021891Biological processolfactory bulb interneuron development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0021930Biological processcerebellar granule cell precursor proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0015631Molecular functiontubulin binding
GO_0019900Molecular functionkinase binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATF5
Protein nameCyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx)
Activating transcription factor 5
SynonymsATFX
DescriptionFUNCTION: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation . Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 . Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation . Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 . Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver . In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase . May act as a negative regulator of IL1B transduction pathway in liver . Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members . Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation . Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material . .

AccessionsENST00000596658.1
ENST00000597227.5
M0R0D5
M0R040
ENST00000600336.1
ENST00000595125.5
ENST00000423777.7
M0QZD2
Q9Y2D1