PROC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030195Biological processnegative regulation of blood coagulation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050819Biological processnegative regulation of coagulation
GO_0007596Biological processblood coagulation
GO_0006508Biological processproteolysis
GO_1903142Biological processpositive regulation of establishment of endothelial barrier
GO_0005615Cellular componentextracellular space
GO_0005796Cellular componentGolgi lumen
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePROC
Protein nameVitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
Protein C
Protein C, inactivator of coagulation factors Va and VIIIa
Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV)
Protein C (EC 3.4.21.69)
Synonyms
DescriptionFUNCTION: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids . Exerts a protective effect on the endothelial cell barrier function . .

AccessionsI7BL31
Q8J009
ENST00000409048.1
Q8J008
E7ENR9
ENST00000431364.1
Q8J003
ENST00000234071.8 [P04070-1]
Q8J002
Q8J004
ENST00000429925.5
ENST00000402125.2
F2Z2A0
P04070
ENST00000442644.5
E7EU72
H7BYX9
Q8J005
Q8J007
ENST00000427769.5
E7END6
Q8J006
E7EVH6
ENST00000419985.5