NUAK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NUAK2 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0042149Biological processcellular response to glucose starvation
GO_0030036Biological processactin cytoskeleton organization
GO_0006468Biological processprotein phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0034504Biological processprotein localization to nucleus
GO_0035330Biological processregulation of hippo signaling
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameNUAK2
Protein nameNUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)
SynonymsSNARK
OMPHK2
DescriptionFUNCTION: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway . .

AccessionsENST00000367157.6
Q9H093