GO_0006915 | OmnibusX

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	ALDH1A3-CRABP2+RARB	-	Ligand-Receptor	Signaling by Retinoic Acid
2	ALDH1A3-CRABP2+RARB+RXRB	-	Ligand-Receptor	Signaling by Retinoic Acid
3	ALDH1A3-CRABP2+RARG	-	Ligand-Receptor	Signaling by Retinoic Acid
4	ALDH1A3-CRABP2+RARG+RXRG	-	Ligand-Receptor	Signaling by Retinoic Acid
5	CEACAM5-CEACAM6	CEAM5_HUMAN - CEAM6_HUMAN	Adhesion-Adhesion	Adhesion by CEAM
6	FASLG-FAS	TNFL6_HUMAN - TNR6_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
7	FASLG-TNFRSF6B	TNFL6_HUMAN - TNF6B_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
8	IGFBP3-TMEM219	IBP3_HUMAN - TM219_HUMAN	Ligand-Receptor	Signaling by Insulin-like growth factor
9	NTN1-DCC	NET1_HUMAN - DCC_HUMAN	Ligand-Receptor	Signaling by Netrin
10	NTN1-UNC5A	NET1_HUMAN - UNC5A_HUMAN	Ligand-Receptor	Signaling by Netrin
11	NTN1-UNC5B	NET1_HUMAN - UNC5B_HUMAN	Ligand-Receptor	Signaling by Netrin
12	NTN1-UNC5C	NET1_HUMAN - UNC5C_HUMAN	Ligand-Receptor	Signaling by Netrin
13	TNFSF10-TNFRSF10A	TNF10_HUMAN - TR10A_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
14	TNFSF10-TNFRSF10B	TNF10_HUMAN - TR10B_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
15	TNFSF10-TNFRSF10D	TNF10_HUMAN - TR10D_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
16	TNFSF10-TNFRSF11B	TNF10_HUMAN - TR11B_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
17	TNFSF12-TNFRSF12A	TNF12_HUMAN - TNR12_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
18	TNFSF12-TNFRSF25	TNF12_HUMAN - TNR25_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
19	TNFSF14-LTBR	TNF14_HUMAN - TNR3_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
20	TNFSF14-TNFRSF6B	TNF14_HUMAN - TNF6B_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
21	WNT7A-SFRP5	WNT7A_HUMAN - SFRP5_HUMAN	Ligand-Ligand	Signaling by WNT inhibition

II. Literature review

[source]

Name	apoptotic process
ID	GO_0006915
collection_id	Biological process
Alternative ID	GO:0006917, GO:0008632
Exact synonym	apoptotic cell death, apoptotic programmed cell death, programmed cell death by apoptosis
Description	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Related synonym	apoptosis activator activity, caspase-dependent programmed cell death, commitment to apoptosis, induction of apoptosis, induction of apoptosis by p53, signaling (initiator) caspase activity
External URL
Genes	NUDT2 PSMD10 TCHP C6orf120 EMP1 APLP1 NLRP12 CXCR3 CASP2 RPS3 IL1B PRAME NR2E1 PUF60 IL19 MEF2A TRAF3 RARB BAK1 IFI27 PPIA MELK CITED1 ERRFI1 PAEP PROP1 C1D ELMO1 MT-RNR2 NISCH RBM14 THBS1 YBX3 DOCK1 IRF3 BLID BECN1 CEACAM6 ADAM15 CDCA7 TNFSF12 NOTCH2 TNFRSF19 TGFBR1 IL24 HTATIP2 DRAM1 UNC5A CSRNP2 RNF130 MTFP1 TCTN3 DPF1 GULP1 DYNLL1 IFNA2 BNIP1 GADD45B TMEM214 RHBDD1 CASP7 RASSF7 BAX MAPK3 ELMO2 CD47 TOX3 TAF6 TMEM14A DPF2 BIK LGALS1 GZMM SHF IER3 NLRC4 MAL PLSCR3 TP53AIP1 GZMA EPB41L3 CGB7 CHIA VIL1 ASAH2 MX1 IL17A AURKA BCAP31 TP53INP1 TNFRSF6B MARCKS SHC4 RBM5 ZBTB16 KLF11 LTA ATG4D THOC6 CIDEB PDCD2L BAG6 RAF1 CSNK2A2 TRAF7 FAS PCSK9 VEGFA NTN1 NFKB1 BCAP29 PRKD1 ZNF443 KREMEN1 AVEN GPR65 GRAMD4 BIRC7 SRA1 BCL2L15 EDAR KRT20 SPIN2B TBX2 CIDEC JAK2 RNF144B RIPK1 CASP10 PEG3 RTN3 OGT MIEN1 RHOB TRAF1 SRGN PRELID1 TMEM102 SGK1 MYD88 ZFP36L1 MAPK1 BNIPL NLRP1 USP17L24 GADD45G CDK1 TRAF5 RFK ARHGEF6 DNAAF10 S100A8 ZNF385A DAD1 ELMO3 ITCH CASP8 CASP3 PDCD7 BCL2L10 HIPK3 PYCARD BCL2 SH3GLB1 CASP1 IKBKG PDCD1 UXT CXCR4 TRIM69 IL1A NUAK2 PDCD4 ADORA2A SGMS1 NCKAP1 SOD1 STK17B PRICKLE1 TRADD APAF1 BUB1 P2RX1 NLRP3 XAF1 FAF1 TNFRSF21 EVA1A AXIN1 PDCD2 LGALS14 CYFIP2 SLC25A6 USP17L5 AHCYL1 STK3 STK4 CASP4 TRIAP1 TNFSF10 USP17L2 HELLS KCNJ8 CTSV AKTIP USP17L1 CFLAR CIB1 FAM3B C3orf38 IFI6 G2E3 RTKN STEAP3 SULF1 MRPL41 DNASE1 CHI3L1 PTPRH RASSF5 CADM1 S100A14 NOX5 RACK1 LCN2 MAP3K10 CCAR1 EP300 IGFBP3 DCC DAPK1 RTN4 RPS6KB1 BAD ADAMTSL4 UNC5C DPP8 TMEM219 MEF2C IAPP PTK2B MZB1 YARS1 CAAP1 KIF1B RRP1B PAK1 TIA1 CGB3 CARD6 NLRP2 TAOK2 CSRNP1 BIRC6 PIM3 TNFRSF12A MAP2K6 RMDN3 TNFRSF18 SIAH1 AREL1 UNC5B MAP2K7 ZFAND6 ALDH1A3 CASP9 GRK5 MAGI3 DAP SEPTIN4 TRAF4 CHMP3 BCLAF1 PLK3 TPX2 CD5L RALB ERCC2 PDCD5 BCL2L11 RRAGA PRUNE2 CD2 BMX STK17A TLR2 MUL1 MMP9 FATE1 AIPL1 ERCC3 PACS2 THOC1 PHLDA1 NME3 MAPK14 GDF6 TNFRSF25 PARP1 BFAR FXR1 EGLN3 MFSD10 PMAIP1 XBP1 MTCH1 AKAP1 AIMP2 DUX4 CARD8 ARL6IP1 NOA1 LTBR DDIT4 ITGB3BP KANK2 EMC4 PRKCD BRAT1 FEM1B SFRP5 LGALS7 ALOX15B CTSK CASP6 ECSCR PTRH2 TNFAIP8 PMP22 RAD21 TNFRSF9 INPP5D FAM32A MFN2 APBB1 OPA1 SIAH2 GAS2 BOK TNFAIP1 CEACAM5 RIPK2 BCL2L12 PPARD NME6 ING4 RYBP PALB2 WNT7A BAG1 TNFSF14 FASTKD2 AHR FKBP8 PAK5 TMBIM4 LGALS16 CSNK2A1 EBAG9 FADD RFFL TNFRSF10A ADAMTS20 UBE2Z BABAM2 SHB MAP3K9 ZC3H8 TRIM35 RNF183 RASSF6 FAIM MEF2D BIRC2 MCM2 PKN2 MAP1S C19orf12 NAIP COMP HIP1 RNF216 GADD45A TP63 CASP12 KLLN JADE1 EFNA5 CD14 FBXO10 BCL7C ZMAT3 BIRC8 HINT2 PAX3 EMP2 caspase2-piddosome_human GHITM TNFRSF10B CTSC PHLDA2 KCNIP3 USP17L3 CDK11B DLC1 DRAM2 NSG1 SMO SLC5A11 C1QBP VDAC1 PAK2 MRPS30 TRAIP PLAGL1 BEX2 UBE2B MINDY3 CIAPIN1 GML DDIAS DDX41 PEA15 PPP1R15A BIRC5 TNFRSF10D HRK TOPAZ1 RELT PRF1 RNF34 IL2RA TEX11 ESPL1 DIABLO PIDD1 TRIM39 MDM2 NHLH2 IFT57 DAPK2 BCL2L14 PRKCE TAX1BP1 CDK11A DAB2 RARG EI24 AIMP1 SMNDC1 PHLPP1 MYO18A TAF10 CLPTM1L NR4A1 ZC3H12A IFNG SLC5A8 TNIP2 LGALS13 PDCD6IP ZBP1 GLRX2 RRAGC SYCP2 MECOM CTSH ATCAY TNFRSF11B LHX4 ZDHHC16 NOC2L UBE2D3 BIRC3 PTEN RABEP1 INPPL1 PRKCB AIFM1 TCIM HIF3A APIP SYCE3 PDCL3 STK26 SUDS3 SLK LHX3 CASP5 TPT1P8 S100A9 NOD1 HTT ITGB2 PPP1R13L PAWR BRMS1 PLEKHF1 LALBA CHST11 RNF152 EAF2 SH3KBP1 BNIP2 KMT2A EMP3 GZMH DDB1 IRF1 CD2AP CARD14 PAK6 CKAP2 PSME3 ZSWIM2 CHEK1 CAPN3 TCIRG1 ADRA1A BCL2L13 KAT5 FASLG SLTM IFI27L1 PPID KCNJ11 PLSCR1 SLC40A1 MYDGF TGFBR2 CIDEA NEK6 PPP2R2B DAPK3 CTSS IFI27L2 PIM1 FOXO1 SQSTM1 TIAL1 SEMA6A SIX1 PANO1 PAK4 BUB1B MAGEH1 BCL7B BBC3 NKX3-1 PEG10 CSRNP3 FGFR2 GZMB UNC5D NR3C1 TNFAIP3

apoptotic process

I. Involved cell-cell interactions

II. Literature review