RACK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071333Biological processcellular response to glucose stimulus
GO_0051901Biological processpositive regulation of mitochondrial depolarization
GO_2000543Biological processpositive regulation of gastrulation
GO_2000114Biological processregulation of establishment of cell polarity
GO_0043547Biological processpositive regulation of GTPase activity
GO_0010629Biological processnegative regulation of gene expression
GO_0042998Biological processpositive regulation of Golgi to plasma membrane protein transport
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0032880Biological processregulation of protein localization
GO_1900102Biological processnegative regulation of endoplasmic reticulum unfolded protein response
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0106070Biological processregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0007369Biological processgastrulation
GO_0071363Biological processcellular response to growth factor stimulus
GO_0072344Biological processrescue of stalled ribosome
GO_0051302Biological processregulation of cell division
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1903751Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0050765Biological processnegative regulation of phagocytosis
GO_0030335Biological processpositive regulation of cell migration
GO_0043473Biological processpigmentation
GO_0006915Biological processapoptotic process
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0032091Biological processnegative regulation of protein binding
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048511Biological processrhythmic process
GO_0051726Biological processregulation of cell cycle
GO_0017148Biological processnegative regulation of translation
GO_0002181Biological processcytoplasmic translation
GO_0030308Biological processnegative regulation of cell growth
GO_0030496Cellular componentmidbody
GO_0022627Cellular componentcytosolic small ribosomal subunit
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0043204Cellular componentperikaryon
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0015935Cellular componentsmall ribosomal subunit
GO_0001891Cellular componentphagocytic cup
GO_0005737Cellular componentcytoplasm
GO_1990630Cellular componentIRE1-RACK1-PP2A complex
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0019899Molecular functionenzyme binding
GO_0008047Molecular functionenzyme activator activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0008200Molecular functionion channel inhibitor activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0051434Molecular functionBH3 domain binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0043022Molecular functionribosome binding
GO_0045296Molecular functioncadherin binding
GO_0045182Molecular functiontranslation regulator activity
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0005102Molecular functionsignaling receptor binding
GO_0042169Molecular functionSH2 domain binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0030292Molecular functionprotein tyrosine kinase inhibitor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameRACK1
Protein nameSmall ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Receptor for activated C kinase 1
Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1)
SynonymsPIG21
GNB2L1
HLC7
DescriptionFUNCTION: Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression . Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits . Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane . Promotes migration of breast carcinoma cells by binding to and activating RHOA . Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). .; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. .; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. .; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. .; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. .

AccessionsJ3KPE3
ENST00000514455.5
D6RHH4
D6RHJ5
ENST00000502844.5
ENST00000503494.5
ENST00000376817.8
H0YAM7
H0YAF8
I3QNU9
ENST00000512968.5
D6RFZ9
ENST00000502905.5
H0Y9P0
ENST00000507756.5
H0Y8W2
D6RBD0
D6R909
D6RFX4
ENST00000512805.6
H0Y8R5
D6R9L0
ENST00000511900.5
ENST00000504325.5
E9PD14
D6RDI0
D6REE5
ENST00000506312.3
ENST00000626067.1
ENST00000509535.5
D6RF23
ENST00000507000.5
D6R9Z1
ENST00000504128.5
ENST00000511473.5
ENST00000508682.5
D6RAC2
ENST00000503081.1
ENST00000513027.3
D6RGK8
ENST00000511566.5
P63244
ENST00000509148.1
ENST00000504726.1
D6RAU2
ENST00000510199.5