exhausted T cell report

I. Related cell sub types

II. Gene markers

Gene
Number of
supported studies
Average coverage
Other major groups
(express this gene)
Other cell types
(express this gene)
LAG3554% ± 11%012
CD8B563% ± 21%012
GZMH532% ± 9%013
GZMK578% ± 29%017
EOMES432% ± 1%09
CXCR6423% ± 6%09
PRF1558% ± 8%021
IFNG429% ± 7%011
SH2D1A540% ± 12%022
TIGIT443% ± 15%013
PDCD1340% ± 6%04
CD6528% ± 8%024
SIRPG441% ± 14%015
ZAP70543% ± 13%027
GZMM544% ± 15%027
TRAT1426% ± 3%020
SH2D2A441% ± 7%020
SLAMF6325% ± 4%013
THEMIS325% ± 5%017
CD8A569% ± 23%115
GBP5532% ± 10%123
LBHD1329% ± 5%15
GZMA586% ± 12%126
GZMB439% ± 26%117
CD3G571% ± 11%129
CD27573% ± 23%130
DENND2D546% ± 17%223
SIT1552% ± 13%224
HAVCR2434% ± 11%217
CXCR3447% ± 6%217

III. Associated gene sets

GO_0060809Biological processmesodermal to mesenchymal transition involved in gastrulation
GO_0060706Biological processcell differentiation involved in embryonic placenta development
GO_0002903Biological processnegative regulation of B cell apoptotic process
GO_0010002Biological processcardioblast differentiation
GO_0006032Biological processchitin catabolic process
GO_0001783Biological processB cell apoptotic process
GO_0002841Biological processnegative regulation of T cell mediated immune response to tumor cell
GO_0070234Biological processpositive regulation of T cell apoptotic process
GO_0021796Biological processcerebral cortex regionalization
GO_0021895Biological processcerebral cortex neuron differentiation
GO_0050863Biological processregulation of T cell activation
GO_0001714Biological processendodermal cell fate specification
GO_0048382Biological processmesendoderm development

IV. Literature review

[source]
Cell type nameexhausted T cell
SynonymsAn effector T cell that displays impaired effector functions (e.g.
rapid production of effector cytokines
cytotoxicity) and has limited proliferative potential.
Tex cell
Description
ParentCL_0002419