Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| CD8-positive, alpha-beta T cell | 25 studies | 28% ± 13% | |
| T cell | 15 studies | 33% ± 16% | |
| CD4-positive, alpha-beta T cell | 14 studies | 32% ± 18% | |
| naive thymus-derived CD8-positive, alpha-beta T cell | 10 studies | 26% ± 5% | |
| mucosal invariant T cell | 10 studies | 28% ± 12% | |
| CD8-positive, alpha-beta memory T cell | 8 studies | 28% ± 9% | |
| effector memory CD8-positive, alpha-beta T cell | 7 studies | 37% ± 14% | |
| mature NK T cell | 6 studies | 18% ± 3% | |
| gamma-delta T cell | 6 studies | 25% ± 13% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 29% ± 14% | |
| effector CD8-positive, alpha-beta T cell | 5 studies | 23% ± 6% | |
| CD4-positive, alpha-beta memory T cell | 5 studies | 22% ± 6% | |
| effector memory CD4-positive, alpha-beta T cell | 4 studies | 18% ± 2% | |
| effector memory CD8-positive, alpha-beta T cell, terminally differentiated | 4 studies | 36% ± 15% | |
| effector CD4-positive, alpha-beta T cell | 3 studies | 19% ± 4% | |
| exhausted T cell | 3 studies | 25% ± 5% | |
| T follicular helper cell | 3 studies | 19% ± 2% | |
| lymphocyte | 3 studies | 54% ± 10% |
Insufficient scRNA-seq data for expression of THEMIS at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 167.46 | 575 / 578 | 70% | 3.40 | 809 / 1155 |
| stomach | 83% | 53.43 | 299 / 359 | 49% | 1.73 | 141 / 286 |
| thymus | 91% | 79.36 | 597 / 653 | 35% | 5.21 | 212 / 605 |
| breast | 61% | 31.58 | 282 / 459 | 49% | 1.68 | 553 / 1118 |
| prostate | 81% | 51.09 | 198 / 245 | 29% | 0.61 | 147 / 502 |
| kidney | 48% | 36.63 | 43 / 89 | 55% | 2.34 | 497 / 901 |
| intestine | 67% | 85.50 | 651 / 966 | 35% | 0.93 | 185 / 527 |
| spleen | 100% | 311.27 | 241 / 241 | 0% | 0 | 0 / 0 |
| uterus | 61% | 24.31 | 104 / 170 | 34% | 0.97 | 157 / 459 |
| bladder | 62% | 72.81 | 13 / 21 | 29% | 0.79 | 144 / 504 |
| peripheral blood | 90% | 256.36 | 835 / 929 | 0% | 0 | 0 / 0 |
| esophagus | 45% | 18.53 | 644 / 1445 | 40% | 1.01 | 74 / 183 |
| adipose | 82% | 56.39 | 991 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 8.25 | 23 / 29 |
| brain | 60% | 80.70 | 1574 / 2642 | 17% | 0.42 | 117 / 705 |
| liver | 58% | 21.64 | 131 / 226 | 13% | 0.32 | 51 / 406 |
| skin | 33% | 12.21 | 595 / 1809 | 36% | 1.60 | 172 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 2.98 | 31 / 45 |
| pancreas | 27% | 8.22 | 90 / 328 | 38% | 1.10 | 68 / 178 |
| ovary | 27% | 9.16 | 48 / 180 | 17% | 0.31 | 72 / 430 |
| blood vessel | 42% | 23.74 | 559 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 34% | 10.59 | 88 / 258 | 3% | 0.03 | 6 / 230 |
| heart | 20% | 7.07 | 168 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.14 | 6 / 80 |
| muscle | 2% | 0.69 | 17 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0043368 | Biological process | positive T cell selection |
| GO_0043383 | Biological process | negative T cell selection |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0008180 | Cellular component | COP9 signalosome |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| Gene name | THEMIS |
| Protein name | Protein THEMIS (Thymocyte-expressed molecule involved in selection) Thymocyte selection associated Protein THEMIS |
| Synonyms | C6orf190 C6orf207 |
| Description | FUNCTION: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. . |
| Accessions | ENST00000434358.3 ENST00000613862.2 [Q8N1K5-1] ENST00000537166.5 [Q8N1K5-2] ENST00000630369.2 [Q8N1K5-4] ENST00000626040.2 ENST00000368248.5 [Q8N1K5-1] A0A0D9SFD2 A0A0G2JQP7 Q8N1K5 ENST00000610842.4 [Q8N1K5-1] ENST00000614155.3 [Q8N1K5-2] X1WI26 ENST00000368250.5 [Q8N1K5-1] ENST00000626111.2 |