THEMIS report

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of THEMIS at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0043368Biological processpositive T cell selection
GO_0043383Biological processnegative T cell selection
GO_0050852Biological processT cell receptor signaling pathway
GO_0005911Cellular componentcell-cell junction
GO_0008180Cellular componentCOP9 signalosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHEMIS
Protein nameProtein THEMIS (Thymocyte-expressed molecule involved in selection)
Thymocyte selection associated
Protein THEMIS
SynonymsC6orf190
C6orf207
DescriptionFUNCTION: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. .

AccessionsENST00000434358.3
ENST00000613862.2 [Q8N1K5-1]
ENST00000537166.5 [Q8N1K5-2]
ENST00000630369.2 [Q8N1K5-4]
ENST00000626040.2
ENST00000368248.5 [Q8N1K5-1]
A0A0D9SFD2
A0A0G2JQP7
Q8N1K5
ENST00000610842.4 [Q8N1K5-1]
ENST00000614155.3 [Q8N1K5-2]
X1WI26
ENST00000368250.5 [Q8N1K5-1]
ENST00000626111.2