SH2D1A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SH2D1A at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0006968Biological processcellular defense response
GO_0006959Biological processhumoral immune response
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0050776Biological processregulation of immune response
GO_0007267Biological processcell-cell signaling
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSH2D1A
Protein nameSH2 domain containing 1A
Truncated SH2 domain containing 1A
SH2 domain containing 1A (SH2 domain protein 1A, Duncan's disease (Lymphoproliferative syndrome), isoform CRA_a)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
SynonymsDSHP
hCG_15647
SAP
DescriptionFUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 . However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 . Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. .

AccessionsK7XSE5
ENST00000698116.1 [O60880-1]
K7YQB3
ENST00000698117.1
K7XXT7
ENST00000698113.1 [O60880-1]
O60880
ENST00000477673.2 [O60880-5]
ENST00000647259.2
A0A8V8TLH8
ENST00000494073.5 [O60880-6]
ENST00000491950.5 [O60880-3]
ENST00000371139.9 [O60880-1]
ENST00000360027.5 [O60880-4]
ENST00000698118.1 [O60880-1]
A0A2R8Y573