SH2D2A report

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0001525Biological processangiogenesis
GO_0030154Biological processcell differentiation
GO_0042098Biological processT cell proliferation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameSH2D2A
Protein nameSH2 domain containing adapter protein 2 transcript variant 3
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
SH2 domain containing adapter protein 2 transcript variant 4
SynonymsVRAP
SCAP
TSAD
DescriptionFUNCTION: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.

AccessionsQ9NP31
Q5UBZ2
ENST00000368198.7 [Q9NP31-4]
ENST00000392306.2 [Q9NP31-2]
Q5UBZ3
ENST00000368199.8 [Q9NP31-1]