DENND2D report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	34% ± 15%	Explore
CD8-positive, alpha-beta T cell	25 studies	34% ± 17%	Explore
CD4-positive, alpha-beta T cell	21 studies	32% ± 17%	Explore
T cell	16 studies	27% ± 11%	Explore
mature NK T cell	15 studies	33% ± 16%	Explore
regulatory T cell	15 studies	29% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	31% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 16%	Explore
gamma-delta T cell	12 studies	27% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	26% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	31% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	32% ± 12%	Explore
T follicular helper cell	8 studies	34% ± 10%	Explore
mucosal invariant T cell	7 studies	28% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	30% ± 12%	Explore
exhausted T cell	5 studies	46% ± 17%	Explore
epithelial cell	5 studies	22% ± 4%	Explore
lymphocyte	4 studies	24% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	36% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 9%	Explore
double negative thymocyte	3 studies	42% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore
goblet cell	3 studies	23% ± 5%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	22% ± 4%	Explore
lymph node	3 studies	25% ± 7%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1705.04	653 / 653	100%	21.75	605 / 605
lung	100%	2150.39	576 / 578	99%	20.51	1148 / 1155
breast	100%	1335.50	457 / 459	99%	31.41	1111 / 1118
kidney	100%	2026.44	89 / 89	99%	19.81	891 / 901
pancreas	97%	837.72	318 / 328	99%	22.89	176 / 178
prostate	95%	1297.62	232 / 245	94%	11.66	471 / 502
bladder	86%	1809.76	18 / 21	99%	29.70	498 / 504
stomach	84%	1445.16	301 / 359	100%	22.13	285 / 286
intestine	61%	1545.17	594 / 966	100%	21.90	525 / 527
liver	99%	869.06	224 / 226	59%	6.51	239 / 406
esophagus	54%	1354.02	786 / 1445	100%	19.11	183 / 183
ovary	53%	261.64	96 / 180	99%	22.72	427 / 430
skin	80%	1235.51	1450 / 1809	63%	13.67	299 / 472
adrenal gland	100%	1854.54	258 / 258	30%	2.49	69 / 230
uterus	23%	139.56	39 / 170	92%	20.40	421 / 459
lymph node	0%	0	0 / 0	100%	71.19	29 / 29
peripheral blood	100%	4767.73	929 / 929	0%	0	0 / 0
spleen	100%	6690.90	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	25.82	45 / 45
ureter	0%	0	0 / 0	100%	26.46	1 / 1
adipose	99%	1086.65	1186 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	39%	3.99	31 / 80
brain	5%	25.62	126 / 2642	21%	1.56	146 / 705
blood vessel	24%	172.26	319 / 1335	0%	0	0 / 0
heart	9%	43.66	78 / 861	0%	0	0 / 0
muscle	1%	3.74	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0