| Alternative ID | GO:0005086, GO:0005087, GO:0005088, GO:0005089, GO:0005090, GO:0008321, GO:0008433, GO:0016219, GO:0016220, GO:0017034, GO:0017112, GO:0017132, GO:0019839, GO:0030676 |
| Exact synonym | GDP-dissociation stimulator activity, GDS, GEF, Rho guanine nucleotide exchange factor, RhoGEF, guanyl-nucleotide release factor activity, guanyl-nucleotide releasing factor |
| Description | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |