Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 22% ± 6% | |
| astrocyte | 11 studies | 32% ± 13% | |
| oligodendrocyte | 7 studies | 20% ± 4% | |
| capillary endothelial cell | 4 studies | 22% ± 5% | |
| endothelial cell of vascular tree | 3 studies | 23% ± 5% |
Insufficient scRNA-seq data for expression of RAPGEF3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 11172.14 | 180 / 180 | 95% | 14.73 | 408 / 430 |
| thymus | 100% | 11393.73 | 653 / 653 | 94% | 35.14 | 569 / 605 |
| prostate | 99% | 4660.84 | 242 / 245 | 92% | 5.07 | 461 / 502 |
| kidney | 100% | 12849.84 | 89 / 89 | 89% | 7.95 | 806 / 901 |
| brain | 89% | 3860.72 | 2351 / 2642 | 96% | 7.55 | 675 / 705 |
| breast | 100% | 12852.92 | 459 / 459 | 72% | 4.07 | 806 / 1118 |
| uterus | 100% | 7417.95 | 170 / 170 | 67% | 4.26 | 308 / 459 |
| esophagus | 100% | 4174.40 | 1439 / 1445 | 63% | 2.73 | 115 / 183 |
| bladder | 95% | 4526.24 | 20 / 21 | 59% | 3.14 | 295 / 504 |
| intestine | 92% | 2581.17 | 884 / 966 | 61% | 2.26 | 319 / 527 |
| lung | 97% | 3553.19 | 562 / 578 | 51% | 2.29 | 594 / 1155 |
| stomach | 95% | 2555.60 | 342 / 359 | 49% | 1.63 | 139 / 286 |
| skin | 63% | 1826.98 | 1140 / 1809 | 49% | 2.98 | 231 / 472 |
| pancreas | 19% | 280.32 | 61 / 328 | 92% | 6.81 | 163 / 178 |
| adipose | 100% | 12002.41 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5509.59 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 96% | 2885.72 | 824 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 90% | 3538.44 | 1204 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 81% | 1813.14 | 654 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 24% | 377.69 | 63 / 258 | 56% | 2.61 | 129 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 1.93 | 24 / 45 |
| eye | 0% | 0 | 0 / 0 | 48% | 3.75 | 38 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 1.27 | 10 / 29 |
| liver | 1% | 19.85 | 3 / 226 | 19% | 0.57 | 76 / 406 |
| peripheral blood | 0% | 3.53 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051896 | Biological process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0001525 | Biological process | angiogenesis |
| GO_0007265 | Biological process | Ras protein signal transduction |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0007165 | Biological process | signal transduction |
| GO_0008306 | Biological process | associative learning |
| GO_0046827 | Biological process | positive regulation of protein export from nucleus |
| GO_0045765 | Biological process | regulation of angiogenesis |
| GO_0060143 | Biological process | positive regulation of syncytium formation by plasma membrane fusion |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0032486 | Biological process | Rap protein signal transduction |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0061028 | Biological process | establishment of endothelial barrier |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0034242 | Biological process | negative regulation of syncytium formation by plasma membrane fusion |
| GO_0005902 | Cellular component | microvillus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030864 | Cellular component | cortical actin cytoskeleton |
| GO_0030175 | Cellular component | filopodium |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0030552 | Molecular function | cAMP binding |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RAPGEF3 |
| Protein name | Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) RAPGEF3 protein |
| Synonyms | EPAC EPAC1 CGEF1 |
| Description | FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. . |
| Accessions | ENST00000495953.2 ENST00000495465.6 F8W0N0 ENST00000548434.1 ENST00000466322.5 F8VRX1 ENST00000549151.5 [O95398-3] ENST00000449771.7 [O95398-1] ENST00000547856.5 H0YIP6 F8VXK1 ENST00000389212.7 [O95398-1] ENST00000405493.6 [O95398-3] O95398 H0YHS2 Q569L6 F8VVJ6 ENST00000395358.7 [O95398-2] ENST00000548919.5 |
