Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 30% ± 13% | |
astrocyte | 13 studies | 30% ± 14% | |
glutamatergic neuron | 10 studies | 41% ± 25% | |
oligodendrocyte precursor cell | 10 studies | 31% ± 14% | |
oligodendrocyte | 10 studies | 26% ± 10% | |
GABAergic neuron | 9 studies | 39% ± 21% | |
macrophage | 9 studies | 29% ± 11% | |
microglial cell | 9 studies | 27% ± 9% | |
adipocyte | 8 studies | 27% ± 7% | |
fibroblast | 8 studies | 28% ± 10% | |
B cell | 7 studies | 21% ± 5% | |
myeloid cell | 7 studies | 20% ± 4% | |
epithelial cell | 7 studies | 34% ± 14% | |
neuron | 6 studies | 38% ± 18% | |
interneuron | 6 studies | 43% ± 22% | |
retinal cone cell | 6 studies | 23% ± 7% | |
Mueller cell | 6 studies | 26% ± 11% | |
pericyte | 5 studies | 27% ± 9% | |
retinal ganglion cell | 5 studies | 42% ± 15% | |
dendritic cell | 5 studies | 19% ± 3% | |
endothelial cell of lymphatic vessel | 5 studies | 28% ± 7% | |
smooth muscle cell | 5 studies | 23% ± 3% | |
granule cell | 4 studies | 24% ± 4% | |
lymphocyte | 4 studies | 26% ± 10% | |
abnormal cell | 4 studies | 29% ± 14% | |
monocyte | 4 studies | 24% ± 3% | |
club cell | 4 studies | 21% ± 7% | |
type I pneumocyte | 4 studies | 23% ± 8% | |
pancreatic A cell | 3 studies | 40% ± 20% | |
GABAergic interneuron | 3 studies | 25% ± 4% | |
amacrine cell | 3 studies | 22% ± 8% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
mesothelial cell | 3 studies | 23% ± 6% | |
ciliated cell | 3 studies | 25% ± 3% | |
ON-bipolar cell | 3 studies | 22% ± 6% | |
retinal rod cell | 3 studies | 22% ± 1% | |
hepatocyte | 3 studies | 40% ± 20% | |
natural killer cell | 3 studies | 20% ± 3% | |
alveolar macrophage | 3 studies | 28% ± 8% | |
type II pneumocyte | 3 studies | 21% ± 7% | |
basal cell | 3 studies | 35% ± 21% | |
goblet cell | 3 studies | 37% ± 25% | |
transit amplifying cell | 3 studies | 35% ± 25% | |
mast cell | 3 studies | 20% ± 4% | |
mural cell | 3 studies | 28% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 2236.24 | 21 / 21 | 100% | 13.58 | 504 / 504 |
esophagus | 100% | 2245.63 | 1445 / 1445 | 100% | 24.73 | 183 / 183 |
lung | 100% | 2473.42 | 578 / 578 | 100% | 18.38 | 1155 / 1155 |
breast | 100% | 2799.59 | 459 / 459 | 100% | 27.57 | 1116 / 1118 |
brain | 100% | 2094.14 | 2634 / 2642 | 100% | 17.51 | 705 / 705 |
prostate | 100% | 2035.67 | 245 / 245 | 100% | 14.32 | 500 / 502 |
ovary | 100% | 2342.67 | 180 / 180 | 100% | 13.59 | 428 / 430 |
thymus | 100% | 2602.91 | 653 / 653 | 100% | 15.61 | 602 / 605 |
pancreas | 100% | 1281.67 | 327 / 328 | 99% | 14.12 | 177 / 178 |
uterus | 100% | 2510.36 | 170 / 170 | 99% | 15.05 | 455 / 459 |
intestine | 100% | 2267.10 | 966 / 966 | 99% | 13.97 | 522 / 527 |
stomach | 100% | 1662.13 | 359 / 359 | 99% | 16.56 | 282 / 286 |
kidney | 100% | 1620.38 | 89 / 89 | 98% | 15.02 | 886 / 901 |
adrenal gland | 100% | 2324.24 | 258 / 258 | 98% | 16.84 | 225 / 230 |
liver | 100% | 1331.23 | 226 / 226 | 96% | 9.88 | 391 / 406 |
skin | 100% | 2784.16 | 1809 / 1809 | 95% | 22.19 | 450 / 472 |
adipose | 100% | 2761.60 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2912.65 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 24.70 | 29 / 29 |
spleen | 100% | 1914.59 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 14.38 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 5.96 | 1 / 1 |
muscle | 100% | 1891.50 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1532.64 | 835 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 82% | 2187.19 | 765 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 74% | 8.46 | 59 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097051 | Biological process | establishment of protein localization to endoplasmic reticulum membrane |
GO_2000786 | Biological process | positive regulation of autophagosome assembly |
GO_0006886 | Biological process | intracellular protein transport |
GO_1903061 | Biological process | positive regulation of protein lipidation |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_1903373 | Biological process | positive regulation of endoplasmic reticulum tubular network organization |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0008047 | Molecular function | enzyme activator activity |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0030234 | Molecular function | enzyme regulator activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | RAB3GAP2 |
Protein name | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) RAB3 GTPase activating non-catalytic protein subunit 2 |
Synonyms | KIAA0839 |
Description | FUNCTION: Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 . As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP . Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure . Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). . |
Accessions | Q9H2M9 A0A8I5KZB3 ENST00000692972.1 A0A8I5KUS2 ENST00000692813.1 ENST00000687065.1 A0A8I5KRP1 ENST00000687647.1 ENST00000690315.1 ENST00000685664.1 ENST00000685286.1 ENST00000358951.7 [Q9H2M9-1] A0A8I5KWJ9 F8WDJ2 A0A8I5KYQ0 A0A8I5KSQ5 ENST00000691862.1 ENST00000690824.1 ENST00000691661.1 A0A8I5KRK1 A0A8I5QJG4 ENST00000689820.1 ENST00000474178.1 ENST00000686381.1 A0A8I5KY07 A0A8I5QJC9 |