RAB3GAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097051Biological processestablishment of protein localization to endoplasmic reticulum membrane
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0006886Biological processintracellular protein transport
GO_1903061Biological processpositive regulation of protein lipidation
GO_0043087Biological processregulation of GTPase activity
GO_1903373Biological processpositive regulation of endoplasmic reticulum tubular network organization
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0008047Molecular functionenzyme activator activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameRAB3GAP2
Protein nameRab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit)
RAB3 GTPase activating non-catalytic protein subunit 2
SynonymsKIAA0839
DescriptionFUNCTION: Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 . As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP . Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure . Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). .

AccessionsQ9H2M9
A0A8I5KZB3
ENST00000692972.1
A0A8I5KUS2
ENST00000692813.1
ENST00000687065.1
A0A8I5KRP1
ENST00000687647.1
ENST00000690315.1
ENST00000685664.1
ENST00000685286.1
ENST00000358951.7 [Q9H2M9-1]
A0A8I5KWJ9
F8WDJ2
A0A8I5KYQ0
A0A8I5KSQ5
ENST00000691862.1
ENST00000690824.1
ENST00000691661.1
A0A8I5KRK1
A0A8I5QJG4
ENST00000689820.1
ENST00000474178.1
ENST00000686381.1
A0A8I5KY07
A0A8I5QJC9