DOCK8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	37 studies	31% ± 13%	Explore
macrophage	33 studies	38% ± 21%	Explore
natural killer cell	33 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	30 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	27 studies	28% ± 11%	Explore
T cell	26 studies	33% ± 12%	Explore
classical monocyte	26 studies	33% ± 13%	Explore
conventional dendritic cell	24 studies	29% ± 14%	Explore
non-classical monocyte	22 studies	40% ± 13%	Explore
regulatory T cell	21 studies	31% ± 9%	Explore
monocyte	19 studies	42% ± 22%	Explore
naive B cell	19 studies	27% ± 6%	Explore
memory B cell	18 studies	28% ± 5%	Explore
dendritic cell	17 studies	47% ± 21%	Explore
mature NK T cell	16 studies	27% ± 8%	Explore
microglial cell	16 studies	73% ± 18%	Explore
gamma-delta T cell	16 studies	29% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	29% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	32% ± 10%	Explore
myeloid cell	14 studies	42% ± 21%	Explore
plasmacytoid dendritic cell	13 studies	27% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	26% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	27% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	33% ± 14%	Explore
mucosal invariant T cell	11 studies	26% ± 10%	Explore
leukocyte	9 studies	48% ± 28%	Explore
alveolar macrophage	8 studies	47% ± 26%	Explore
neutrophil	8 studies	33% ± 18%	Explore
mast cell	8 studies	30% ± 11%	Explore
plasma cell	7 studies	37% ± 16%	Explore
adipocyte	7 studies	28% ± 6%	Explore
T follicular helper cell	7 studies	26% ± 3%	Explore
innate lymphoid cell	7 studies	27% ± 12%	Explore
endothelial cell of lymphatic vessel	7 studies	35% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	29% ± 7%	Explore
retinal cone cell	6 studies	48% ± 20%	Explore
smooth muscle cell	6 studies	30% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
plasmablast	5 studies	41% ± 15%	Explore
exhausted T cell	5 studies	36% ± 4%	Explore
mononuclear phagocyte	5 studies	39% ± 16%	Explore
hematopoietic stem cell	5 studies	19% ± 4%	Explore
lymphocyte	5 studies	54% ± 22%	Explore
type II pneumocyte	5 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	31% ± 14%	Explore
hematopoietic precursor cell	4 studies	40% ± 26%	Explore
precursor B cell	4 studies	24% ± 3%	Explore
epithelial cell	4 studies	42% ± 24%	Explore
immature B cell	4 studies	26% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	31% ± 3%	Explore
pro-B cell	3 studies	20% ± 1%	Explore
tissue-resident macrophage	3 studies	30% ± 15%	Explore
germinal center B cell	3 studies	24% ± 5%	Explore
CD4-positive helper T cell	3 studies	27% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 11%	Explore
basal cell	3 studies	25% ± 10%	Explore
endothelial cell	3 studies	22% ± 4%	Explore
T-helper 17 cell	3 studies	30% ± 2%	Explore
T-helper 1 cell	3 studies	25% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
double negative thymocyte	3 studies	34% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	28% ± 6%	Explore
abnormal cell	3 studies	28% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	28% ± 9%	Explore
lung	9 studies	24% ± 7%	Explore
bone marrow	4 studies	26% ± 7%	Explore
lymph node	4 studies	25% ± 2%	Explore
brain	4 studies	27% ± 8%	Explore
liver	4 studies	25% ± 4%	Explore
kidney	3 studies	25% ± 6%	Explore
adipose	3 studies	24% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	1988.20	89 / 89	98%	20.66	881 / 901
breast	100%	2095.91	458 / 459	96%	11.27	1070 / 1118
lung	100%	3919.31	576 / 578	92%	9.56	1063 / 1155
thymus	98%	1735.26	642 / 653	93%	9.47	562 / 605
esophagus	97%	3545.28	1403 / 1445	88%	6.52	161 / 183
prostate	96%	1689.60	236 / 245	85%	6.42	425 / 502
bladder	86%	1675.29	18 / 21	84%	6.88	423 / 504
stomach	89%	1052.35	320 / 359	78%	6.45	222 / 286
pancreas	68%	615.22	222 / 328	90%	8.44	161 / 178
adrenal gland	100%	4142.28	258 / 258	56%	5.18	129 / 230
intestine	81%	1886.19	787 / 966	74%	5.22	391 / 527
uterus	79%	723.41	135 / 170	74%	4.56	339 / 459
skin	61%	621.03	1106 / 1809	77%	8.35	364 / 472
brain	27%	301.19	713 / 2642	87%	7.05	615 / 705
ovary	46%	398.70	82 / 180	62%	3.12	268 / 430
lymph node	0%	0	0 / 0	100%	40.89	29 / 29
spleen	100%	14439.34	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.48	1 / 1
peripheral blood	100%	10335.54	928 / 929	0%	0	0 / 0
adipose	100%	2382.10	1201 / 1204	0%	0	0 / 0
liver	52%	438.42	117 / 226	41%	2.22	167 / 406
tonsil	0%	0	0 / 0	87%	9.57	39 / 45
eye	0%	0	0 / 0	84%	5.36	67 / 80
blood vessel	54%	707.65	721 / 1335	0%	0	0 / 0
heart	28%	233.34	245 / 861	0%	0	0 / 0
muscle	3%	17.80	23 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070233	Biological process	negative regulation of T cell apoptotic process
GO_0001771	Biological process	immunological synapse formation
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_1903905	Biological process	positive regulation of establishment of T cell polarity
GO_0061485	Biological process	memory T cell proliferation
GO_0036336	Biological process	dendritic cell migration
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_1990869	Biological process	cellular response to chemokine
GO_2000406	Biological process	positive regulation of T cell migration
GO_0031256	Cellular component	leading edge membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0031252	Cellular component	cell leading edge
GO_0031258	Cellular component	lamellipodium membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DOCK8
Protein name	Dedicator of cytokinesis 8 Dedicator of cytokinesis protein 8 DOCK8 DOCK8 protein
Synonyms
Description	FUNCTION: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP . During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane . Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing . .
Accessions	ENST00000469391.5 [Q8NF50-4] ENST00000682249.1 ENST00000524396.5 Q86XD0 A0A2X0SFD1 ENST00000469197.5 C9J7A3 A2A369 Q8NF50 E2J6M6 F8WC95 E9PHZ4 E2J6M5 ENST00000462618.1 ENST00000382329.2 E9PDJ4 ENST00000487230.5 ENST00000432829.7 [Q8NF50-1] ENST00000483757.6 A0A8I5KQK5 ENST00000453981.5 [Q8NF50-3] A0A804HK14

DOCK8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review