DOCK5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904694Biological processnegative regulation of vascular associated smooth muscle contraction
GO_0071800Biological processpodosome assembly
GO_0046849Biological processbone remodeling
GO_0016601Biological processRac protein signal transduction
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0007520Biological processmyoblast fusion
GO_0016477Biological processcell migration
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0005886Cellular componentplasma membrane
GO_0002102Cellular componentpodosome
GO_0005829Cellular componentcytosol
GO_0070161Cellular componentanchoring junction
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDOCK5
Protein nameDOCK5
Dedicator of cytokinesis protein 5
Dedicator of cytokinesis 5
Synonyms
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen . .

AccessionsH0YB14
ENST00000467709.6
B9A015
A0A2X0SFZ7
ENST00000410074.5
ENST00000276440.12 [Q9H7D0-1]
H0Y7N4
ENST00000444569.5
ENST00000481100.5 [Q9H7D0-2]
Q9H7D0