PLEKHG6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLEKHG6 at tissue level.

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0005902Cellular componentmicrovillus
GO_0005813Cellular componentcentrosome
GO_0030054Cellular componentcell junction
GO_0032154Cellular componentcleavage furrow
GO_0005829Cellular componentcytosol
GO_0000922Cellular componentspindle pole
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene namePLEKHG6
Protein namePLEKHG6
Pleckstrin homology and RhoGEF domain containing G6
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
Synonyms
DescriptionFUNCTION: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. .

AccessionsENST00000011684.11 [Q3KR16-1]
ENST00000396988.7 [Q3KR16-1]
ENST00000536531.5
A0A2X0TW08
ENST00000304581.8 [Q3KR16-3]
ENST00000449001.6 [Q3KR16-2]
ENST00000684764.1 [Q3KR16-1]
F5H731
Q3KR16