Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 26% ± 5% | |
| epithelial cell | 5 studies | 30% ± 10% | |
| ciliated cell | 4 studies | 21% ± 3% | |
| non-classical monocyte | 3 studies | 21% ± 7% | |
| glutamatergic neuron | 3 studies | 39% ± 15% | |
| dendritic cell | 3 studies | 24% ± 7% | |
| club cell | 3 studies | 17% ± 1% | |
| basal cell | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 26% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 4235.76 | 21 / 21 | 100% | 34.50 | 504 / 504 |
| breast | 100% | 4227.10 | 459 / 459 | 100% | 37.68 | 1118 / 1118 |
| esophagus | 100% | 3838.66 | 1445 / 1445 | 100% | 30.30 | 183 / 183 |
| liver | 100% | 2396.08 | 226 / 226 | 100% | 18.15 | 406 / 406 |
| lung | 100% | 3959.86 | 578 / 578 | 100% | 38.50 | 1155 / 1155 |
| ovary | 100% | 4036.54 | 180 / 180 | 100% | 20.68 | 430 / 430 |
| prostate | 100% | 5168.86 | 245 / 245 | 100% | 38.01 | 502 / 502 |
| skin | 100% | 4178.90 | 1809 / 1809 | 100% | 32.21 | 472 / 472 |
| stomach | 100% | 3365.14 | 359 / 359 | 100% | 25.11 | 286 / 286 |
| uterus | 100% | 3991.42 | 170 / 170 | 100% | 40.32 | 459 / 459 |
| intestine | 100% | 4084.77 | 966 / 966 | 100% | 27.87 | 526 / 527 |
| kidney | 100% | 3181.33 | 89 / 89 | 100% | 21.58 | 899 / 901 |
| thymus | 100% | 4443.74 | 653 / 653 | 100% | 25.69 | 603 / 605 |
| brain | 99% | 3040.46 | 2628 / 2642 | 100% | 27.77 | 705 / 705 |
| pancreas | 100% | 2407.44 | 328 / 328 | 99% | 25.20 | 177 / 178 |
| adrenal gland | 100% | 3644.15 | 258 / 258 | 99% | 19.33 | 227 / 230 |
| adipose | 100% | 3450.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 21.69 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 38.68 | 29 / 29 |
| muscle | 100% | 4765.95 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5249.18 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 45.22 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 24.75 | 1 / 1 |
| blood vessel | 100% | 3094.25 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2694.33 | 849 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 2123.28 | 849 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0014003 | Biological process | oligodendrocyte development |
| GO_0002183 | Biological process | cytoplasmic translational initiation |
| GO_0009408 | Biological process | response to heat |
| GO_0021766 | Biological process | hippocampus development |
| GO_0045948 | Biological process | positive regulation of translational initiation |
| GO_0043434 | Biological process | response to peptide hormone |
| GO_0009749 | Biological process | response to glucose |
| GO_0042552 | Biological process | myelination |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0001541 | Biological process | ovarian follicle development |
| GO_0006413 | Biological process | translational initiation |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0048708 | Biological process | astrocyte differentiation |
| GO_0014002 | Biological process | astrocyte development |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0005851 | Cellular component | eukaryotic translation initiation factor 2B complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0031369 | Molecular function | translation initiation factor binding |
| GO_0003743 | Molecular function | translation initiation factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EIF2B5 |
| Protein name | Eukaryotic translation initiation factor 2B subunit epsilon Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) |
| Synonyms | EIF2BE |
| Description | FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit . Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed . . |
| Accessions | ENST00000648890.1 ENST00000648599.1 A0A3B3ITG6 ENST00000647636.1 A0A3B3IT53 ENST00000649545.1 ENST00000648682.1 C9JRD9 ENST00000471832.2 ENST00000647909.1 ENST00000432982.5 ENST00000648882.1 ENST00000492773.6 ENST00000648189.1 A0A3B3ITQ2 ENST00000648915.2 A0A3B3IUF2 A0A3B3ISS1 ENST00000648314.1 A0A3B3IS56 ENST00000648630.1 ENST00000650270.1 A0A3B3IUB1 ENST00000649688.1 A0A3B3IST9 A0A3B3ISV1 A0A3B3ITK8 H7C2X0 ENST00000648145.1 Q13144 ENST00000648256.1 A0A3B3ISX3 A0A3B3IRP4 A0A3B3ISA5 ENST00000432569.2 ENST00000650244.1 A0A3B3ISM8 A0A3B3ISI2 |
