MYCBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0051493Biological processregulation of cytoskeleton organization
GO_0032880Biological processregulation of protein localization
GO_0050905Biological processneuromuscular process
GO_0032922Biological processcircadian regulation of gene expression
GO_1902667Biological processregulation of axon guidance
GO_0021785Biological processbranchiomotor neuron axon guidance
GO_0021952Biological processcentral nervous system projection neuron axonogenesis
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0008582Biological processregulation of synaptic assembly at neuromuscular junction
GO_0007411Biological processaxon guidance
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYCBP2
Protein nameMYC binding protein 2
RCR-type E3 ubiquitin transferase (EC 2.3.2.33)
E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)
SynonymsPAM
KIAA0916
DescriptionFUNCTION: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues . Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates . Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 . Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown . Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin . Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia . May function as a facilitator or regulator of transcriptional activation by MYC . Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 . .

AccessionsA0A8Q3SHQ2
ENST00000695079.1
ENST00000357337.11
A0A804HJ25
A0A8Q3SHK7
ENST00000544440.7 [O75592-1]
A0A804HKQ1
ENST00000695080.1
ENST00000684354.1
A0A8Q3SHQ6
ENST00000682321.1
O75592
ENST00000683823.1
ENST00000429715.1
ENST00000683697.1
A0A499FJI4
A0A804HL12
H7C3U4
A0A804HIR9
ENST00000695081.1