RAB3GAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097051Biological processestablishment of protein localization to endoplasmic reticulum membrane
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_1903061Biological processpositive regulation of protein lipidation
GO_0043547Biological processpositive regulation of GTPase activity
GO_0060079Biological processexcitatory postsynaptic potential
GO_1903373Biological processpositive regulation of endoplasmic reticulum tubular network organization
GO_0061646Biological processpositive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
GO_0043087Biological processregulation of GTPase activity
GO_0034389Biological processlipid droplet organization
GO_1903233Biological processregulation of calcium ion-dependent exocytosis of neurotransmitter
GO_0007420Biological processbrain development
GO_0043010Biological processcamera-type eye development
GO_0060325Biological processface morphogenesis
GO_0021854Biological processhypothalamus development
GO_0048172Biological processregulation of short-term neuronal synaptic plasticity
GO_0005811Cellular componentlipid droplet
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0098794Cellular componentpostsynapse
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRAB3GAP1
Protein nameRab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)
RAB3 GTPase activating protein catalytic subunit 1
Rab3 GTPase-activating protein catalytic subunit
SynonymsKIAA0066
RAB3GAP
hCG_25660
DescriptionFUNCTION: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 . As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP . Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones . The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP . Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure . Required for normal eye and brain development . May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters . .

AccessionsC9J1R5
B9A6J2
A0A8I5KSB6
ENST00000687199.1
A0A8J9AUI2
ENST00000264158.13 [Q15042-1]
ENST00000688182.1
ENST00000539493.3
Q15042
ENST00000691339.1
A0A8I5KW23
ENST00000425393.1
A0A8I5KRH8
ENST00000685967.1
ENST00000442034.5 [Q15042-3]
A0A8I5KWG9
ENST00000690208.1
ENST00000693554.1
A0A8I5KT44
ENST00000691478.1
A0A8I5KRB1