Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 31% ± 12% | |
astrocyte | 13 studies | 35% ± 16% | |
fibroblast | 13 studies | 26% ± 10% | |
macrophage | 12 studies | 30% ± 13% | |
B cell | 11 studies | 21% ± 6% | |
microglial cell | 11 studies | 35% ± 12% | |
oligodendrocyte | 11 studies | 33% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 33% ± 16% | |
GABAergic neuron | 9 studies | 41% ± 22% | |
glutamatergic neuron | 9 studies | 56% ± 22% | |
adipocyte | 9 studies | 27% ± 7% | |
neuron | 7 studies | 35% ± 18% | |
naive B cell | 7 studies | 20% ± 4% | |
epithelial cell | 7 studies | 38% ± 18% | |
retinal cone cell | 7 studies | 39% ± 13% | |
ciliated cell | 7 studies | 27% ± 8% | |
smooth muscle cell | 7 studies | 24% ± 4% | |
interneuron | 6 studies | 47% ± 24% | |
myeloid cell | 6 studies | 25% ± 6% | |
basal cell | 6 studies | 33% ± 19% | |
dendritic cell | 6 studies | 25% ± 4% | |
endothelial cell of lymphatic vessel | 6 studies | 31% ± 10% | |
type I pneumocyte | 6 studies | 29% ± 9% | |
type II pneumocyte | 6 studies | 24% ± 6% | |
pericyte | 6 studies | 24% ± 8% | |
club cell | 5 studies | 25% ± 7% | |
amacrine cell | 5 studies | 22% ± 8% | |
cardiac muscle cell | 5 studies | 34% ± 7% | |
monocyte | 5 studies | 27% ± 7% | |
classical monocyte | 4 studies | 18% ± 2% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
non-classical monocyte | 4 studies | 20% ± 3% | |
gamma-delta T cell | 4 studies | 23% ± 3% | |
retinal ganglion cell | 4 studies | 34% ± 11% | |
retinal pigment epithelial cell | 4 studies | 34% ± 25% | |
mast cell | 4 studies | 24% ± 4% | |
lymphocyte | 4 studies | 22% ± 7% | |
retina horizontal cell | 4 studies | 23% ± 11% | |
retinal rod cell | 4 studies | 34% ± 8% | |
abnormal cell | 4 studies | 25% ± 14% | |
T cell | 4 studies | 21% ± 4% | |
goblet cell | 4 studies | 37% ± 27% | |
regulatory T cell | 4 studies | 18% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 17% ± 2% | |
GABAergic interneuron | 3 studies | 31% ± 3% | |
glial cell | 3 studies | 21% ± 5% | |
granule cell | 3 studies | 25% ± 4% | |
memory B cell | 3 studies | 18% ± 0% | |
plasma cell | 3 studies | 31% ± 6% | |
mesothelial cell | 3 studies | 28% ± 6% | |
mononuclear phagocyte | 3 studies | 23% ± 5% | |
vein endothelial cell | 3 studies | 31% ± 16% | |
GABAergic amacrine cell | 3 studies | 28% ± 10% | |
Mueller cell | 3 studies | 25% ± 10% | |
glycinergic amacrine cell | 3 studies | 21% ± 3% | |
endothelial cell of vascular tree | 3 studies | 31% ± 17% | |
hepatocyte | 3 studies | 39% ± 19% | |
muscle cell | 3 studies | 34% ± 21% | |
ependymal cell | 3 studies | 38% ± 16% | |
alveolar macrophage | 3 studies | 34% ± 10% | |
capillary endothelial cell | 3 studies | 21% ± 4% | |
respiratory goblet cell | 3 studies | 37% ± 12% | |
mucus secreting cell | 3 studies | 31% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5013.50 | 1445 / 1445 | 100% | 35.01 | 183 / 183 |
lung | 100% | 3776.33 | 578 / 578 | 100% | 35.72 | 1155 / 1155 |
prostate | 100% | 4236.36 | 245 / 245 | 100% | 38.11 | 502 / 502 |
breast | 100% | 4163.31 | 459 / 459 | 100% | 43.65 | 1117 / 1118 |
thymus | 100% | 3827.45 | 653 / 653 | 100% | 40.48 | 604 / 605 |
brain | 100% | 3612.04 | 2637 / 2642 | 100% | 38.51 | 705 / 705 |
intestine | 100% | 4588.77 | 966 / 966 | 100% | 30.96 | 526 / 527 |
bladder | 100% | 4923.95 | 21 / 21 | 100% | 30.47 | 503 / 504 |
stomach | 100% | 3571.20 | 359 / 359 | 100% | 29.27 | 285 / 286 |
skin | 100% | 5623.65 | 1809 / 1809 | 100% | 35.76 | 470 / 472 |
uterus | 100% | 5053.65 | 170 / 170 | 100% | 35.09 | 457 / 459 |
pancreas | 100% | 2450.59 | 328 / 328 | 99% | 36.02 | 177 / 178 |
kidney | 100% | 2574.38 | 89 / 89 | 99% | 34.53 | 895 / 901 |
ovary | 100% | 4498.46 | 180 / 180 | 98% | 20.13 | 421 / 430 |
adrenal gland | 100% | 3263.17 | 258 / 258 | 97% | 32.43 | 222 / 230 |
liver | 100% | 1534.73 | 226 / 226 | 94% | 15.35 | 380 / 406 |
adipose | 100% | 4144.14 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6626.58 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 28.29 | 29 / 29 |
muscle | 100% | 4474.42 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3173.85 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 39.31 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.29 | 1 / 1 |
heart | 99% | 3430.92 | 849 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 26.70 | 77 / 80 |
peripheral blood | 78% | 1847.21 | 727 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097051 | Biological process | establishment of protein localization to endoplasmic reticulum membrane |
GO_2000786 | Biological process | positive regulation of autophagosome assembly |
GO_1903061 | Biological process | positive regulation of protein lipidation |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0060079 | Biological process | excitatory postsynaptic potential |
GO_1903373 | Biological process | positive regulation of endoplasmic reticulum tubular network organization |
GO_0061646 | Biological process | positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_0034389 | Biological process | lipid droplet organization |
GO_1903233 | Biological process | regulation of calcium ion-dependent exocytosis of neurotransmitter |
GO_0007420 | Biological process | brain development |
GO_0043010 | Biological process | camera-type eye development |
GO_0060325 | Biological process | face morphogenesis |
GO_0021854 | Biological process | hypothalamus development |
GO_0048172 | Biological process | regulation of short-term neuronal synaptic plasticity |
GO_0005811 | Cellular component | lipid droplet |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0071782 | Cellular component | endoplasmic reticulum tubular network |
GO_0070062 | Cellular component | extracellular exosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0098794 | Cellular component | postsynapse |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | RAB3GAP1 |
Protein name | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) RAB3 GTPase activating protein catalytic subunit 1 Rab3 GTPase-activating protein catalytic subunit |
Synonyms | KIAA0066 RAB3GAP hCG_25660 |
Description | FUNCTION: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 . As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP . Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones . The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP . Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure . Required for normal eye and brain development . May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters . . |
Accessions | C9J1R5 B9A6J2 A0A8I5KSB6 ENST00000687199.1 A0A8J9AUI2 ENST00000264158.13 [Q15042-1] ENST00000688182.1 ENST00000539493.3 Q15042 ENST00000691339.1 A0A8I5KW23 ENST00000425393.1 A0A8I5KRH8 ENST00000685967.1 ENST00000442034.5 [Q15042-3] A0A8I5KWG9 ENST00000690208.1 ENST00000693554.1 A0A8I5KT44 ENST00000691478.1 A0A8I5KRB1 |