EIF2B4 | OmnibusX

Name	Number of supported studies	Average coverage
liver	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	2655.19	21 / 21	100%	21.74	504 / 504
esophagus	100%	2825.79	1445 / 1445	100%	16.50	183 / 183
liver	100%	1390.62	226 / 226	100%	16.15	406 / 406
ovary	100%	2362.71	180 / 180	100%	18.02	430 / 430
pancreas	100%	2122.72	328 / 328	100%	19.10	178 / 178
prostate	100%	3402.63	245 / 245	100%	37.79	502 / 502
skin	100%	2740.66	1809 / 1809	100%	23.95	472 / 472
stomach	100%	2108.88	359 / 359	100%	17.96	286 / 286
thymus	100%	2527.77	653 / 653	100%	22.41	605 / 605
lung	100%	2155.21	578 / 578	100%	20.41	1154 / 1155
intestine	100%	2709.61	966 / 966	100%	20.04	526 / 527
uterus	100%	2574.42	170 / 170	100%	23.57	458 / 459
breast	100%	2514.88	459 / 459	100%	25.31	1115 / 1118
brain	100%	1684.19	2634 / 2642	100%	24.97	705 / 705
adrenal gland	100%	2782.54	258 / 258	100%	15.61	229 / 230
kidney	100%	1826.64	89 / 89	98%	14.79	884 / 901
adipose	100%	2274.07	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	24.23	80 / 80
lymph node	0%	0	0 / 0	100%	23.30	29 / 29
muscle	100%	2674.69	803 / 803	0%	0	0 / 0
spleen	100%	2299.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.05	45 / 45
ureter	0%	0	0 / 0	100%	15.64	1 / 1
blood vessel	100%	2333.15	1334 / 1335	0%	0	0 / 0
heart	99%	1697.82	855 / 861	0%	0	0 / 0
peripheral blood	90%	937.35	835 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0014003	Biological process	oligodendrocyte development
GO_0002183	Biological process	cytoplasmic translational initiation
GO_0009408	Biological process	response to heat
GO_0006413	Biological process	translational initiation
GO_0043434	Biological process	response to peptide hormone
GO_0009749	Biological process	response to glucose
GO_0042552	Biological process	myelination
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0001541	Biological process	ovarian follicle development
GO_0006417	Biological process	regulation of translation
GO_0005737	Cellular component	cytoplasm
GO_0005829	Cellular component	cytosol
GO_0005851	Cellular component	eukaryotic translation initiation factor 2B complex
GO_0003743	Molecular function	translation initiation factor activity
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0031369	Molecular function	translation initiation factor binding
GO_0005515	Molecular function	protein binding

Gene name	EIF2B4
Protein name	Eukaryotic translation initiation factor 2B subunit 4 delta transcript variant 4 (Eukaryotic translation initiation factor 2B subunit delta) Eukaryotic translation initiation factor 2B subunit delta Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)
Synonyms	EIF2BD
Description	FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit . Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed . .
Accessions	ENST00000405940.6 Q9UI10 ENST00000418146.1 ENST00000493344.6 ENST00000451130.6 [Q9UI10-2] F8W8L6 ENST00000347454.9 [Q9UI10-1] E7ERK9 ENST00000445933.6 [Q9UI10-3] F8WEV6

EIF2B4 report