Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 31 studies | 45% ± 17% | |
astrocyte | 17 studies | 52% ± 21% | |
oligodendrocyte | 15 studies | 63% ± 18% | |
oligodendrocyte precursor cell | 15 studies | 59% ± 21% | |
fibroblast | 13 studies | 44% ± 15% | |
smooth muscle cell | 12 studies | 34% ± 13% | |
pericyte | 11 studies | 37% ± 14% | |
endothelial cell of lymphatic vessel | 10 studies | 42% ± 18% | |
adipocyte | 9 studies | 32% ± 13% | |
epithelial cell | 8 studies | 35% ± 20% | |
endothelial cell of artery | 8 studies | 29% ± 16% | |
mesothelial cell | 6 studies | 37% ± 12% | |
ciliated cell | 6 studies | 31% ± 14% | |
basal cell | 6 studies | 52% ± 24% | |
macrophage | 5 studies | 37% ± 8% | |
microglial cell | 5 studies | 40% ± 23% | |
capillary endothelial cell | 5 studies | 35% ± 15% | |
type I pneumocyte | 5 studies | 51% ± 12% | |
type II pneumocyte | 5 studies | 45% ± 11% | |
cholangiocyte | 4 studies | 50% ± 20% | |
vein endothelial cell | 4 studies | 39% ± 17% | |
club cell | 4 studies | 52% ± 12% | |
GABAergic neuron | 3 studies | 41% ± 15% | |
glial cell | 3 studies | 36% ± 8% | |
Mueller cell | 3 studies | 27% ± 12% | |
endothelial cell of vascular tree | 3 studies | 58% ± 18% | |
hepatocyte | 3 studies | 48% ± 21% | |
connective tissue cell | 3 studies | 36% ± 8% | |
ependymal cell | 3 studies | 44% ± 21% | |
alveolar macrophage | 3 studies | 29% ± 3% | |
myofibroblast cell | 3 studies | 41% ± 22% | |
respiratory goblet cell | 3 studies | 56% ± 21% | |
goblet cell | 3 studies | 37% ± 27% | |
mucus secreting cell | 3 studies | 51% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4992.95 | 1445 / 1445 | 100% | 32.82 | 183 / 183 |
breast | 100% | 6970.30 | 459 / 459 | 99% | 38.04 | 1107 / 1118 |
lung | 100% | 4330.86 | 577 / 578 | 99% | 27.40 | 1144 / 1155 |
intestine | 100% | 5447.91 | 966 / 966 | 99% | 23.48 | 520 / 527 |
prostate | 100% | 5634.95 | 245 / 245 | 98% | 28.15 | 494 / 502 |
stomach | 100% | 3525.44 | 359 / 359 | 98% | 25.32 | 281 / 286 |
thymus | 100% | 7913.88 | 653 / 653 | 98% | 40.33 | 593 / 605 |
pancreas | 99% | 2594.98 | 326 / 328 | 98% | 31.08 | 175 / 178 |
brain | 99% | 5384.48 | 2603 / 2642 | 99% | 34.35 | 698 / 705 |
kidney | 100% | 4872.16 | 89 / 89 | 97% | 30.85 | 872 / 901 |
skin | 100% | 7501.46 | 1809 / 1809 | 96% | 27.56 | 455 / 472 |
uterus | 100% | 6344.94 | 170 / 170 | 96% | 26.36 | 440 / 459 |
bladder | 100% | 5373.10 | 21 / 21 | 95% | 20.54 | 481 / 504 |
ovary | 100% | 6072.11 | 180 / 180 | 90% | 15.86 | 385 / 430 |
liver | 91% | 1372.92 | 206 / 226 | 75% | 11.75 | 306 / 406 |
adrenal gland | 99% | 2597.94 | 255 / 258 | 56% | 7.88 | 128 / 230 |
adipose | 100% | 6167.28 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6275.68 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.00 | 1 / 1 |
spleen | 98% | 2303.45 | 236 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 22.98 | 44 / 45 |
heart | 97% | 2290.99 | 838 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 19.09 | 73 / 80 |
muscle | 28% | 372.95 | 226 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 24% | 1.90 | 7 / 29 |
peripheral blood | 0% | 1.03 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0150052 | Biological process | regulation of postsynapse assembly |
GO_0007165 | Biological process | signal transduction |
GO_0006911 | Biological process | phagocytosis, engulfment |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_0007264 | Biological process | small GTPase-mediated signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
GO_0007520 | Biological process | myoblast fusion |
GO_0016477 | Biological process | cell migration |
GO_0010634 | Biological process | positive regulation of epithelial cell migration |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0032045 | Cellular component | guanyl-nucleotide exchange factor complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0098794 | Cellular component | postsynapse |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | DOCK1 |
Protein name | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) Dedicator of cytokinesis 1 DOCK1 |
Synonyms | |
Description | FUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen . Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 . . |
Accessions | Q14185 A0A096LNH6 ENST00000623213.2 B2RUU3 A0A2X0U2H5 ENST00000280333.9 |