DOCK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0150052Biological processregulation of postsynapse assembly
GO_0007165Biological processsignal transduction
GO_0006911Biological processphagocytosis, engulfment
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0006915Biological processapoptotic process
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0007520Biological processmyoblast fusion
GO_0016477Biological processcell migration
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0098978Cellular componentglutamatergic synapse
GO_0032045Cellular componentguanyl-nucleotide exchange factor complex
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameDOCK1
Protein nameDedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Dedicator of cytokinesis 1
DOCK1
Synonyms
DescriptionFUNCTION: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen . Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 . .

AccessionsQ14185
A0A096LNH6
ENST00000623213.2
B2RUU3
A0A2X0U2H5
ENST00000280333.9