Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 21 studies | 27% ± 7% | |
non-classical monocyte | 18 studies | 28% ± 13% | |
macrophage | 17 studies | 34% ± 13% | |
memory B cell | 14 studies | 22% ± 6% | |
conventional dendritic cell | 13 studies | 27% ± 14% | |
microglial cell | 13 studies | 36% ± 17% | |
naive B cell | 12 studies | 23% ± 7% | |
dendritic cell | 10 studies | 41% ± 19% | |
myeloid cell | 10 studies | 29% ± 13% | |
monocyte | 9 studies | 29% ± 10% | |
plasmacytoid dendritic cell | 8 studies | 25% ± 9% | |
classical monocyte | 6 studies | 28% ± 12% | |
immature B cell | 4 studies | 25% ± 4% | |
mononuclear phagocyte | 4 studies | 37% ± 16% | |
precursor B cell | 3 studies | 20% ± 5% | |
tissue-resident macrophage | 3 studies | 21% ± 7% | |
alveolar macrophage | 3 studies | 37% ± 8% |
Insufficient scRNA-seq data for expression of FGD2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 3041.61 | 578 / 578 | 90% | 4.25 | 1040 / 1155 |
thymus | 98% | 1175.00 | 638 / 653 | 76% | 2.94 | 461 / 605 |
breast | 89% | 727.19 | 408 / 459 | 81% | 2.59 | 902 / 1118 |
esophagus | 90% | 617.95 | 1296 / 1445 | 79% | 2.26 | 144 / 183 |
intestine | 96% | 1494.92 | 924 / 966 | 73% | 2.28 | 383 / 527 |
bladder | 95% | 889.71 | 20 / 21 | 71% | 2.57 | 359 / 504 |
uterus | 70% | 347.02 | 119 / 170 | 76% | 2.52 | 349 / 459 |
stomach | 68% | 419.78 | 244 / 359 | 77% | 2.46 | 219 / 286 |
kidney | 60% | 478.00 | 53 / 89 | 84% | 3.99 | 758 / 901 |
prostate | 88% | 648.78 | 215 / 245 | 52% | 1.07 | 261 / 502 |
brain | 43% | 255.81 | 1133 / 2642 | 97% | 5.16 | 682 / 705 |
skin | 65% | 403.55 | 1180 / 1809 | 72% | 3.49 | 340 / 472 |
adrenal gland | 96% | 1151.60 | 248 / 258 | 37% | 0.75 | 84 / 230 |
pancreas | 41% | 194.72 | 136 / 328 | 90% | 4.60 | 160 / 178 |
ovary | 43% | 209.04 | 77 / 180 | 83% | 3.04 | 359 / 430 |
liver | 60% | 395.49 | 136 / 226 | 46% | 1.16 | 188 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.19 | 29 / 29 |
spleen | 100% | 14689.42 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 3756.27 | 928 / 929 | 0% | 0 | 0 / 0 |
adipose | 98% | 1414.78 | 1176 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 4.33 | 41 / 45 |
blood vessel | 67% | 581.70 | 901 / 1335 | 0% | 0 | 0 / 0 |
heart | 61% | 337.94 | 525 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 24% | 0.64 | 19 / 80 |
muscle | 16% | 60.72 | 130 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_0046847 | Biological process | filopodium assembly |
GO_0008360 | Biological process | regulation of cell shape |
GO_0001726 | Cellular component | ruffle |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005856 | Cellular component | cytoskeleton |
GO_0031901 | Cellular component | early endosome membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0046872 | Molecular function | metal ion binding |
GO_1901981 | Molecular function | phosphatidylinositol phosphate binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FGD2 |
Protein name | FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4) FGD2 FYVE, RhoGEF and PH domain containing 2 |
Synonyms | ZFYVE4 |
Description | FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). . |
Accessions | H7BY95 Q7Z6J4 A0A2X0SYZ7 ENST00000373535.6 ENST00000274963.13 [Q7Z6J4-1] |