FGD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGD2 at tissue level.

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007010Biological processcytoskeleton organization
GO_0030036Biological processactin cytoskeleton organization
GO_0043087Biological processregulation of GTPase activity
GO_0046847Biological processfilopodium assembly
GO_0008360Biological processregulation of cell shape
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0005856Cellular componentcytoskeleton
GO_0031901Cellular componentearly endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGD2
Protein nameFYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)
FGD2
FYVE, RhoGEF and PH domain containing 2
SynonymsZFYVE4
DescriptionFUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). .

AccessionsH7BY95
Q7Z6J4
A0A2X0SYZ7
ENST00000373535.6
ENST00000274963.13 [Q7Z6J4-1]