RAPGEF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030033Biological processmicrovillus assembly
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0007265Biological processRas protein signal transduction
GO_0072659Biological processprotein localization to plasma membrane
GO_0043087Biological processregulation of GTPase activity
GO_0043547Biological processpositive regulation of GTPase activity
GO_0016324Cellular componentapical plasma membrane
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0070300Molecular functionphosphatidic acid binding
GO_0030742Molecular functionGTP-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameRAPGEF6
Protein nameHCG1981012, isoform CRA_b (RAPGEF6 protein)
Rap guanine nucleotide exchange factor 6
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
SynonymsPDZGEF2
hCG_1981012
DescriptionFUNCTION: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. .

AccessionsENST00000513227.5
D6RD23
B7Z7Y1
D6RB02
ENST00000308008.10 [Q8TEU7-2]
ENST00000507093.5 [Q8TEU7-3]
ENST00000510071.5 [Q8TEU7-6]
ENST00000509018.6 [Q8TEU7-1]
D6RIH0
D6RE77
B2RTU6
ENST00000296859.10 [Q8TEU7-4]
ENST00000504039.2
ENST00000671916.1
A0A5F9ZHG7
Q8TEU7
ENST00000627212.2 [Q8TEU7-5]
ENST00000512052.5
ENST00000504575.5
ENST00000515170.5