ARHGEF15 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	13 studies	23% ± 9%	Explore
capillary endothelial cell	8 studies	21% ± 7%	Explore
glomerular endothelial cell	3 studies	18% ± 1%	Explore
endothelial cell of vascular tree	3 studies	21% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARHGEF15 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2641.53	653 / 653	97%	12.27	588 / 605
breast	100%	8124.72	459 / 459	96%	9.14	1071 / 1118
prostate	97%	1657.99	237 / 245	89%	4.91	446 / 502
adrenal gland	93%	1055.58	240 / 258	90%	8.11	207 / 230
lung	100%	4525.54	578 / 578	82%	4.76	943 / 1155
kidney	100%	2680.00	89 / 89	78%	16.69	702 / 901
bladder	95%	2418.71	20 / 21	79%	4.23	399 / 504
stomach	85%	1031.93	306 / 359	83%	5.20	237 / 286
intestine	87%	1244.60	844 / 966	78%	3.95	412 / 527
esophagus	88%	1552.67	1273 / 1445	74%	3.95	136 / 183
uterus	99%	2698.67	168 / 170	59%	2.97	270 / 459
skin	66%	954.43	1197 / 1809	75%	4.15	356 / 472
pancreas	31%	255.24	102 / 328	94%	7.50	168 / 178
ovary	52%	563.07	94 / 180	52%	1.98	225 / 430
adipose	100%	8737.78	1204 / 1204	0%	0	0 / 0
heart	99%	2649.86	854 / 861	0%	0	0 / 0
spleen	98%	1570.76	237 / 241	0%	0	0 / 0
liver	14%	108.38	32 / 226	83%	4.26	336 / 406
brain	13%	94.04	345 / 2642	72%	3.00	509 / 705
muscle	85%	900.03	682 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	2.76	22 / 29
blood vessel	71%	1219.12	944 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	62%	2.47	28 / 45
eye	0%	0	0 / 0	30%	0.98	24 / 80
peripheral blood	0%	0.56	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0150052	Biological process	regulation of postsynapse assembly
GO_2000297	Biological process	negative regulation of synapse maturation
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0090630	Biological process	activation of GTPase activity
GO_0061299	Biological process	retina vasculature morphogenesis in camera-type eye
GO_0050790	Biological process	regulation of catalytic activity
GO_0098978	Cellular component	glutamatergic synapse
GO_0005737	Cellular component	cytoplasm
GO_0005829	Cellular component	cytosol
GO_0030425	Cellular component	dendrite
GO_0098794	Cellular component	postsynapse
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding
GO_0005096	Molecular function	GTPase activator activity

Gene name	ARHGEF15
Protein name	Rho guanine nucleotide exchange factor 15 isoform 2 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) ARHGEF15 Rho guanine nucleotide exchange factor 15 isoform 1
Synonyms	KIAA0915
Description	FUNCTION: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. .
Accessions	ENST00000583529.1 A0A3B3IUF8 ENST00000579439.5 J3KT46 O94989 A0A0S2Z543 A0A2X0SFP9 J3QQS4 ENST00000361926.8 ENST00000647883.1 J3QS60 ENST00000581809.1 A0A0S2Z547 ENST00000421050.2

ARHGEF15 report