EPS8L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007266Biological processRho protein signal transduction
GO_0007605Biological processsensory perception of sound
GO_1900029Biological processpositive regulation of ruffle assembly
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0032587Cellular componentruffle membrane
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0031982Cellular componentvesicle
GO_0032426Cellular componentstereocilium tip
GO_0005886Cellular componentplasma membrane
GO_0032421Cellular componentstereocilium bundle
GO_0045296Molecular functioncadherin binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameEPS8L2
Protein nameEpidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
EPS8 like 2
SynonymsEPS8R2
PP13181
DescriptionFUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). .

AccessionsENST00000528770.5
H0YF37
ENST00000530636.5 [Q9H6S3-1]
ENST00000533256.5 [Q9H6S3-1]
A0A3B3ISQ4
ENST00000527199.5
ENST00000526909.5
ENST00000650127.1
ENST00000524763.5
ENST00000534755.5
ENST00000526198.5 [Q9H6S3-3]
H0YD62
E9PM34
ENST00000614442.4 [Q9H6S3-3]
E9PLN2
E9PN68
ENST00000531348.5
E9PNT0
E9PNY4
Q9H6S3
ENST00000533500.5
E9PLH1
ENST00000530452.6
ENST00000318562.13 [Q9H6S3-1]