MCF2L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0035556Biological processintracellular signal transduction
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0005615Cellular componentextracellular space
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0019898Cellular componentextrinsic component of membrane
GO_0012505Cellular componentendomembrane system
GO_0005737Cellular componentcytoplasm
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameMCF2L
Protein nameMCF2L
MCF.2 cell line derived transforming sequence like
Guanine nucleotide exchange factor DBS
Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)
MCF2L protein
SynonymsKIAA0362
OST
DescriptionFUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 . .; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 . .

AccessionsENST00000413354.5
ENST00000409954.6
ENST00000453297.6
ENST00000421756.5 [O15068-3]
ENST00000375608.7 [O15068-1]
B7ZBR9
ENST00000704386.1
ENST00000442625.2
H3BLT1
H7C275
X6RE72
ENST00000473345.5
A0A994J4L8
A2A3G7
ENST00000375604.6 [O15068-10]
A2A640
ENST00000486806.1
ENST00000441756.1
A2A639
H0Y4M6
H0Y7A3
ENST00000397036.4
ENST00000420013.6
H7BYP9
ENST00000535094.7 [O15068-9]
Q3B839
H0Y519
Q3B838
M0R1J7
ENST00000397017.6
A2A3H1
ENST00000439475.1
O15068
ENST00000397021.5
ENST00000433807.5
F8WBK7
H7C2S1
ENST00000375597.8 [O15068-4]
ENST00000261963.11
M0R393
Q3YL89
A0A2X0U4S1
ENST00000397030.5 [O15068-2]
ENST00000423251.1
ENST00000397024.1