Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 25 studies | 32% ± 14% | |
microglial cell | 12 studies | 44% ± 20% | |
glutamatergic neuron | 10 studies | 39% ± 25% | |
capillary endothelial cell | 10 studies | 21% ± 6% | |
oligodendrocyte precursor cell | 9 studies | 28% ± 14% | |
GABAergic neuron | 8 studies | 39% ± 23% | |
retinal cone cell | 7 studies | 36% ± 14% | |
oligodendrocyte | 7 studies | 26% ± 8% | |
neuron | 6 studies | 34% ± 13% | |
interneuron | 6 studies | 42% ± 21% | |
vein endothelial cell | 6 studies | 34% ± 22% | |
goblet cell | 5 studies | 36% ± 16% | |
endothelial cell of artery | 4 studies | 19% ± 4% | |
granule cell | 4 studies | 38% ± 13% | |
GABAergic interneuron | 3 studies | 30% ± 16% | |
epithelial cell | 3 studies | 24% ± 7% | |
endothelial cell of vascular tree | 3 studies | 37% ± 19% | |
retinal pigment epithelial cell | 3 studies | 27% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 98% | 5647.88 | 239 / 245 | 100% | 10.63 | 501 / 502 |
brain | 100% | 15639.41 | 2632 / 2642 | 98% | 12.56 | 688 / 705 |
breast | 100% | 10301.72 | 459 / 459 | 96% | 10.04 | 1078 / 1118 |
thymus | 100% | 8163.85 | 653 / 653 | 94% | 6.18 | 567 / 605 |
kidney | 100% | 4303.43 | 89 / 89 | 92% | 8.83 | 826 / 901 |
intestine | 95% | 3794.14 | 922 / 966 | 94% | 7.33 | 494 / 527 |
stomach | 97% | 3447.12 | 350 / 359 | 91% | 7.28 | 261 / 286 |
pancreas | 90% | 2400.80 | 295 / 328 | 95% | 7.39 | 169 / 178 |
esophagus | 98% | 3882.42 | 1410 / 1445 | 83% | 7.39 | 151 / 183 |
lung | 99% | 5721.58 | 571 / 578 | 77% | 5.13 | 890 / 1155 |
bladder | 95% | 3935.00 | 20 / 21 | 78% | 5.64 | 392 / 504 |
uterus | 99% | 5825.60 | 169 / 170 | 58% | 4.30 | 268 / 459 |
skin | 72% | 3440.49 | 1302 / 1809 | 63% | 9.82 | 297 / 472 |
adrenal gland | 34% | 855.68 | 88 / 258 | 71% | 12.90 | 164 / 230 |
adipose | 100% | 10405.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
heart | 98% | 5427.30 | 846 / 861 | 0% | 0 | 0 / 0 |
muscle | 82% | 2088.05 | 659 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 82% | 2595.30 | 1091 / 1335 | 0% | 0 | 0 / 0 |
liver | 35% | 579.88 | 78 / 226 | 40% | 1.50 | 161 / 406 |
ovary | 30% | 729.67 | 54 / 180 | 34% | 1.31 | 147 / 430 |
tonsil | 0% | 0 | 0 / 0 | 60% | 3.85 | 27 / 45 |
eye | 0% | 0 | 0 / 0 | 50% | 4.30 | 40 / 80 |
spleen | 30% | 568.71 | 73 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.22 | 3 / 29 |
peripheral blood | 0% | 1.89 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0035025 | Biological process | positive regulation of Rho protein signal transduction |
GO_0005615 | Cellular component | extracellular space |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0019898 | Cellular component | extrinsic component of membrane |
GO_0012505 | Cellular component | endomembrane system |
GO_0005737 | Cellular component | cytoplasm |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0035091 | Molecular function | phosphatidylinositol binding |
Gene name | MCF2L |
Protein name | MCF2L MCF.2 cell line derived transforming sequence like Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) MCF2L protein |
Synonyms | KIAA0362 OST |
Description | FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 . .; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 . . |
Accessions | ENST00000413354.5 ENST00000409954.6 ENST00000453297.6 ENST00000421756.5 [O15068-3] ENST00000375608.7 [O15068-1] B7ZBR9 ENST00000704386.1 ENST00000442625.2 H3BLT1 H7C275 X6RE72 ENST00000473345.5 A0A994J4L8 A2A3G7 ENST00000375604.6 [O15068-10] A2A640 ENST00000486806.1 ENST00000441756.1 A2A639 H0Y4M6 H0Y7A3 ENST00000397036.4 ENST00000420013.6 H7BYP9 ENST00000535094.7 [O15068-9] Q3B839 H0Y519 Q3B838 M0R1J7 ENST00000397017.6 A2A3H1 ENST00000439475.1 O15068 ENST00000397021.5 ENST00000433807.5 F8WBK7 H7C2S1 ENST00000375597.8 [O15068-4] ENST00000261963.11 M0R393 Q3YL89 A0A2X0U4S1 ENST00000397030.5 [O15068-2] ENST00000423251.1 ENST00000397024.1 |