ARFGEF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	36% ± 14%	Explore
oligodendrocyte precursor cell	13 studies	38% ± 19%	Explore
astrocyte	13 studies	39% ± 17%	Explore
microglial cell	13 studies	39% ± 14%	Explore
glutamatergic neuron	12 studies	44% ± 26%	Explore
oligodendrocyte	12 studies	34% ± 13%	Explore
ciliated cell	11 studies	27% ± 9%	Explore
GABAergic neuron	11 studies	47% ± 24%	Explore
macrophage	11 studies	35% ± 15%	Explore
fibroblast	11 studies	34% ± 10%	Explore
epithelial cell	10 studies	36% ± 21%	Explore
basal cell	9 studies	37% ± 21%	Explore
adipocyte	9 studies	36% ± 12%	Explore
smooth muscle cell	9 studies	29% ± 9%	Explore
mast cell	8 studies	26% ± 7%	Explore
pericyte	8 studies	32% ± 11%	Explore
T cell	7 studies	29% ± 8%	Explore
endothelial cell of lymphatic vessel	7 studies	37% ± 14%	Explore
myeloid cell	7 studies	30% ± 7%	Explore
retinal cone cell	7 studies	54% ± 16%	Explore
retinal rod cell	7 studies	38% ± 18%	Explore
dendritic cell	7 studies	32% ± 9%	Explore
B cell	6 studies	24% ± 7%	Explore
natural killer cell	6 studies	27% ± 6%	Explore
respiratory goblet cell	6 studies	37% ± 15%	Explore
CD4-positive, alpha-beta T cell	6 studies	23% ± 7%	Explore
neuron	6 studies	48% ± 24%	Explore
interneuron	6 studies	57% ± 22%	Explore
retinal ganglion cell	6 studies	34% ± 16%	Explore
club cell	6 studies	34% ± 10%	Explore
classical monocyte	5 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	5 studies	23% ± 5%	Explore
cardiac muscle cell	5 studies	39% ± 10%	Explore
monocyte	5 studies	37% ± 8%	Explore
type I pneumocyte	5 studies	36% ± 9%	Explore
type II pneumocyte	5 studies	30% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 7%	Explore
granule cell	4 studies	35% ± 8%	Explore
mesothelial cell	4 studies	30% ± 8%	Explore
lymphocyte	4 studies	41% ± 16%	Explore
amacrine cell	4 studies	32% ± 11%	Explore
retina horizontal cell	4 studies	35% ± 14%	Explore
goblet cell	4 studies	37% ± 32%	Explore
ionocyte	3 studies	22% ± 7%	Explore
secretory cell	3 studies	31% ± 6%	Explore
leukocyte	3 studies	32% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	24% ± 5%	Explore
hematopoietic precursor cell	3 studies	32% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	26% ± 7%	Explore
GABAergic interneuron	3 studies	47% ± 10%	Explore
plasma cell	3 studies	29% ± 6%	Explore
squamous epithelial cell	3 studies	39% ± 24%	Explore
vein endothelial cell	3 studies	42% ± 22%	Explore
retinal bipolar neuron	3 studies	25% ± 7%	Explore
GABAergic amacrine cell	3 studies	29% ± 10%	Explore
Mueller cell	3 studies	48% ± 20%	Explore
ON-bipolar cell	3 studies	32% ± 13%	Explore
glycinergic amacrine cell	3 studies	33% ± 8%	Explore
rod bipolar cell	3 studies	34% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	17% ± 3%	Explore
endothelial cell of vascular tree	3 studies	41% ± 20%	Explore
hepatocyte	3 studies	48% ± 20%	Explore
retinal pigment epithelial cell	3 studies	36% ± 28%	Explore
ependymal cell	3 studies	33% ± 17%	Explore
alveolar macrophage	3 studies	45% ± 11%	Explore
capillary endothelial cell	3 studies	32% ± 9%	Explore
transit amplifying cell	3 studies	43% ± 35%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 10%	Explore
renal principal cell	3 studies	32% ± 8%	Explore
mural cell	3 studies	39% ± 12%	Explore
mucus secreting cell	3 studies	35% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	40% ± 21%	Explore
lung	8 studies	29% ± 8%	Explore
eye	7 studies	41% ± 18%	Explore
heart	4 studies	34% ± 5%	Explore
peripheral blood	3 studies	21% ± 1%	Explore
intestine	3 studies	17% ± 1%	Explore
adipose	3 studies	36% ± 7%	Explore
kidney	3 studies	31% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3884.42	1445 / 1445	100%	35.60	183 / 183
lung	100%	3853.34	578 / 578	100%	28.25	1154 / 1155
breast	100%	3656.10	459 / 459	100%	51.05	1117 / 1118
bladder	100%	4203.43	21 / 21	100%	27.21	502 / 504
prostate	100%	3680.59	245 / 245	99%	24.94	499 / 502
intestine	100%	4186.76	966 / 966	99%	27.47	523 / 527
pancreas	100%	2481.23	327 / 328	99%	24.64	177 / 178
thymus	100%	4485.12	653 / 653	99%	28.22	599 / 605
stomach	100%	3398.58	359 / 359	99%	30.22	282 / 286
ovary	100%	3018.25	180 / 180	98%	17.52	423 / 430
uterus	100%	3321.54	170 / 170	98%	21.96	450 / 459
brain	99%	2090.77	2609 / 2642	99%	16.75	699 / 705
kidney	100%	3981.69	89 / 89	97%	20.62	878 / 901
skin	100%	4813.48	1809 / 1809	92%	18.86	433 / 472
adrenal gland	100%	3435.24	258 / 258	91%	13.76	209 / 230
liver	100%	1750.57	226 / 226	86%	11.11	350 / 406
adipose	100%	3516.52	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3315.41	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	17.30	29 / 29
muscle	100%	2676.01	803 / 803	0%	0	0 / 0
spleen	100%	3917.09	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	23.79	45 / 45
ureter	0%	0	0 / 0	100%	17.42	1 / 1
heart	97%	1981.09	835 / 861	0%	0	0 / 0
peripheral blood	96%	3065.46	888 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	75%	17.37	60 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010256	Biological process	endomembrane system organization
GO_0030837	Biological process	negative regulation of actin filament polymerization
GO_0034260	Biological process	negative regulation of GTPase activity
GO_2000114	Biological process	regulation of establishment of cell polarity
GO_0007030	Biological process	Golgi organization
GO_0032012	Biological process	regulation of ARF protein signal transduction
GO_0006887	Biological process	exocytosis
GO_0015031	Biological process	protein transport
GO_0006486	Biological process	protein glycosylation
GO_0090303	Biological process	positive regulation of wound healing
GO_0005730	Cellular component	nucleolus
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005802	Cellular component	trans-Golgi network
GO_0016363	Cellular component	nuclear matrix
GO_0000139	Cellular component	Golgi membrane
GO_0005829	Cellular component	cytosol
GO_0030532	Cellular component	small nuclear ribonucleoprotein complex
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0034237	Molecular function	protein kinase A regulatory subunit binding
GO_0017022	Molecular function	myosin binding
GO_0005096	Molecular function	GTPase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARFGEF1
Protein name	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms	ARFGEP1 BIG1
Description	FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. .
Accessions	ENST00000518789.5 E5RHL7 E5RJN9 ENST00000519436.1 ENST00000520381.5 ENST00000518230.5 ENST00000262215.8 E5RIF2 Q9Y6D6 E5RHZ1

ARFGEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review