RASGRP1 | OmnibusX

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	17 studies	21% ± 6%	Explore
regulatory T cell	16 studies	22% ± 5%	Explore
T cell	15 studies	24% ± 8%	Explore
natural killer cell	13 studies	20% ± 6%	Explore
CD4-positive, alpha-beta T cell	13 studies	25% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	28% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 7%	Explore
mature NK T cell	7 studies	21% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	24% ± 6%	Explore
gamma-delta T cell	6 studies	23% ± 7%	Explore
Mueller cell	6 studies	44% ± 16%	Explore
glutamatergic neuron	5 studies	39% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	24% ± 7%	Explore
astrocyte	5 studies	35% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	26% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	19% ± 1%	Explore
exhausted T cell	4 studies	27% ± 10%	Explore
mucosal invariant T cell	4 studies	24% ± 5%	Explore
lymphocyte	4 studies	38% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
CD4-positive helper T cell	3 studies	23% ± 5%	Explore
GABAergic neuron	3 studies	28% ± 4%	Explore
granule cell	3 studies	34% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	20% ± 1%	Explore
brain	3 studies	37% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	96%	560.94	85 / 89	86%	9.12	771 / 901
lung	92%	679.78	533 / 578	83%	6.05	956 / 1155
brain	83%	2045.57	2198 / 2642	91%	9.53	641 / 705
skin	76%	1193.25	1368 / 1809	47%	3.09	223 / 472
breast	36%	141.72	164 / 459	80%	9.35	891 / 1118
esophagus	39%	500.71	559 / 1445	74%	5.27	136 / 183
spleen	100%	1054.02	241 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	18.34	28 / 29
pancreas	22%	61.98	71 / 328	70%	4.47	124 / 178
tonsil	0%	0	0 / 0	87%	6.94	39 / 45
peripheral blood	86%	1750.32	802 / 929	0%	0	0 / 0
stomach	19%	59.20	69 / 359	49%	2.91	140 / 286
intestine	29%	159.31	277 / 966	34%	1.94	179 / 527
uterus	7%	23.92	12 / 170	55%	3.45	254 / 459
thymus	24%	109.38	155 / 653	38%	5.49	227 / 605
bladder	19%	62.67	4 / 21	38%	2.13	189 / 504
ovary	3%	6.67	5 / 180	53%	2.37	230 / 430
adipose	41%	174.22	490 / 1204	0%	0	0 / 0
prostate	14%	43.81	35 / 245	13%	0.45	66 / 502
liver	5%	12.87	11 / 226	12%	0.53	49 / 406
heart	16%	51.49	139 / 861	0%	0	0 / 0
blood vessel	10%	40.69	137 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	9%	0.37	7 / 80
adrenal gland	2%	9.60	5 / 258	5%	0.16	11 / 230
muscle	1%	1.75	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051896	Biological process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007265	Biological process	Ras protein signal transduction
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0045954	Biological process	positive regulation of natural killer cell mediated cytotoxicity
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0042098	Biological process	T cell proliferation
GO_0090630	Biological process	activation of GTPase activity
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0007165	Biological process	signal transduction
GO_0030101	Biological process	natural killer cell activation
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0032252	Biological process	secretory granule localization
GO_0002437	Biological process	inflammatory response to antigenic stimulus
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0043303	Biological process	mast cell degranulation
GO_0032825	Biological process	positive regulation of natural killer cell differentiation
GO_0032725	Biological process	positive regulation of granulocyte macrophage colony-stimulating factor production
GO_0030154	Biological process	cell differentiation
GO_0042113	Biological process	B cell activation
GO_1900744	Biological process	regulation of p38MAPK cascade
GO_0046579	Biological process	positive regulation of Ras protein signal transduction
GO_0033089	Biological process	positive regulation of T cell differentiation in thymus
GO_0042100	Biological process	B cell proliferation
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0042110	Biological process	T cell activation
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0047496	Biological process	vesicle transport along microtubule
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0000139	Cellular component	Golgi membrane
GO_0005829	Cellular component	cytosol
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0008289	Molecular function	lipid binding
GO_0042802	Molecular function	identical protein binding
GO_0031210	Molecular function	phosphatidylcholine binding
GO_0008270	Molecular function	zinc ion binding
GO_0005509	Molecular function	calcium ion binding
GO_0019992	Molecular function	diacylglycerol binding

IV. Literature review

[source]

Gene name	RASGRP1
Protein name	RAS guanyl releasing protein 1 RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) RAS guanyl-releasing protein 1
Synonyms	RASGRP
Description	FUNCTION: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP . Activates the Erk/MAP kinase cascade . Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras . Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways . Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types . .
Accessions	ENST00000450598.6 [O95267-2] ENST00000558418.6 H0YKM0 ENST00000560929.1 A0A8V8TLA7 H0YNK9 ENST00000558432.5 ENST00000697782.1 ENST00000559830.5 [O95267-3] A0A8V8TL86 H0YNG8 H0YN83 H0YKP8 ENST00000560425.1 ENST00000558164.5 [O95267-5] ENST00000557875.1 ENST00000561180.5 ENST00000697785.1 ENST00000697780.1 ENST00000414708.6 [O95267-4] ENST00000697786.1 ENST00000697784.1 ENST00000561117.6 ENST00000310803.10 [O95267-1] A0A8V8TMY7 ENST00000697783.1 H0YMT0 A0A8V8TMY1 O95267

RASGRP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review