GO_0070374 | OmnibusX

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	ANGPT1-TEK	ANGP1_HUMAN - TIE2_HUMAN	Ligand-Receptor	Signaling by Angiopoietin
2	APOE-TREM2+TYROBP	APOE_HUMAN -	Ligand-Receptor	Signaling by Apolipoprotein
3	APP-CD74	A4_HUMAN - HG2A_HUMAN	Ligand-Receptor	Signaling by Amyloid-beta precursor protein
4	APP-FPR2	A4_HUMAN - FPR2_HUMAN	Ligand-Receptor	Signaling by Amyloid-beta precursor protein
5	APP-TREM2+TYROBP	A4_HUMAN -	Ligand-Receptor	Signaling by Amyloid-beta precursor protein
6	CCL19-CCR7	CCL19_HUMAN - CCR7_HUMAN	Ligand-Receptor	Signaling by Chemokines
7	CCL21-CCR7	CCL21_HUMAN - CCR7_HUMAN	Ligand-Receptor	Signaling by Chemokines
8	CCL3-CCR1	CCL3_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
9	FGA+FGB+FGG-ITGA2B+ITGB3	-	Ligand-Receptor	Adhesion by Fibribogen
10	FGF1-FGFR2	FGF1_HUMAN - FGFR2_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
11	FGF1-FGFR3	FGF1_HUMAN - FGFR3_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
12	FGF1-FGFR4	FGF1_HUMAN - FGFR4_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
13	FGF1-ITGAV+ITGB3	FGF1_HUMAN -	Ligand-Receptor	Signaling by Fibroblast growth factor
14	FGF10-FGFR2	FGF10_HUMAN - FGFR2_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
15	FGF19-FGFR4+KLB	FGF19_HUMAN -	Ligand-Receptor	Signaling by Fibroblast growth factor
16	FGF2-FGFR2	FGF2_HUMAN - FGFR2_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
17	FGF2-FGFR3	FGF2_HUMAN - FGFR3_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
18	FGF2-FGFR4	FGF2_HUMAN - FGFR4_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
19	FGF2-ITGAV+ITGB3	FGF2_HUMAN -	Ligand-Receptor	Signaling by Fibroblast growth factor
20	FGF20-FGFR3	FGF20_HUMAN - FGFR3_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
21	FGF21-FGFR4+KLB	FGF21_HUMAN -	Ligand-Receptor	Signaling by Fibroblast growth factor
22	FGF8-FGFR3	FGF8_HUMAN - FGFR3_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
23	IGF1-ITGAV+ITGB3	IGF1_HUMAN -	Ligand-Receptor	Signaling by Insulin-like growth factor
24	LGALS9-BCR+CD22+PTPRC	LEG9_HUMAN -	Ligand-Receptor	Signaling by Galectin
25	LGALS9-HAVCR2	LEG9_HUMAN - HAVR2_HUMAN	Ligand-Receptor	Signaling by Galectin
26	NRG1-ERBB4	NRG1_HUMAN - ERBB4_HUMAN	Ligand-Receptor	Signaling by Neuregulin
27	PDGFA-PDGFRA	PDGFA_HUMAN - PGFRA_HUMAN	Ligand-Receptor	Signaling by Platelet-derived growth factor
28	PDGFB-PDGFRA	PDGFB_HUMAN - PGFRA_HUMAN	Ligand-Receptor	Signaling by Platelet-derived growth factor
29	PDGFB-PDGFRA+PDGFRB	PDGFB_HUMAN -	Ligand-Receptor	Signaling by Platelet-derived growth factor
30	PDGFB-PDGFRB	PDGFB_HUMAN - PGFRB_HUMAN	Ligand-Receptor	Signaling by Platelet-derived growth factor
31	PDGFC-PDGFRA	PDGFC_HUMAN - PGFRA_HUMAN	Ligand-Receptor	Signaling by Platelet-derived growth factor
32	PDGFD-PDGFRA+PDGFRB	PDGFD_HUMAN -	Ligand-Receptor	Signaling by Platelet-derived growth factor
33	PDGFD-PDGFRB	PDGFD_HUMAN - PGFRB_HUMAN	Ligand-Receptor	Signaling by Platelet-derived growth factor
34	TNFSF11-TNFRSF11A	TNF11_HUMAN - TNR11_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor

Name	positive regulation of ERK1 and ERK2 cascade
ID	GO_0070374
collection_id	Biological process
Exact synonym	positive regulation of ERK1 and ERK2 signaling pathway, positive regulation of ERK1 and ERK2 signalling pathway, positive regulation of ERK1/2 cascade, up regulation of ERK1 and ERK2 cascade, up-regulation of ERK1 and ERK2 cascade, upregulation of ERK1 and ERK2 cascade
Description	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
External URL
Genes	CCL19 ICAM1 URS00005540D2_9606 FBXW7 MARCO THPO PRKCA PRXL2C MT3 NRG1 PDGFA SERPINF2 HTR2B F2RL1 DDR1 FGG PYCARD FGA GAS6 HAND2 SYT14P1 APP FGF18 GNAI2 INHBA TNFAIP8L3 HLA-DRB1 CSF1R MFHAS1 FSHR CCL3 CCN2 BMPER GPR55 FERMT2 BRAF IL1A URS000059311D_9606 FGF21 PDGFRA RAP1B PDE8B NTRK3 ADCYAP1 CX3CL1 NOTCH2 TNFRSF11A DDT FGF1 SSTR4 PDGFB CCL21 NTRK2 C5AR1 NPY5R NTRK1 P2RY6 CXCL17 FFAR4 FGF2 GPNMB PDGFD GPR183 ROR2 APELA CCR1 GAREM1 RAMP3 URS0000324096_9606 CD36 PHB2 CD4 ALKAL1 SRC MAPK3 ARRB2 PRKCZ PLA2G5 TGFB1 EGFR RIPK2 SEMA7A abeta-42-oligomer_human BMP2 FGF4 URS00001F1DA8_9606 CASR CFLAR CIB1 GCG ACKR3 NRXN1 URS000059273E_9606 ARRB1 DSTYK NOD1 ABCA7 URS000039ED8D_9606 RAPGEF2 ITGB3 CHI3L1 APOE ANGPT1 HAVCR2 ERBB4 PTPRC FGFR4 KDR MAP2K1 FGF20 CCR7 PRKD2 URS00003B95DA_9606 F2R HMGB1 ARHGAP8 MUSK NOD2 ALKAL2 MIF PDGFC RASGRP1 FLT4 FGF19 GPER1 LGALS9 NELFE DNAJC27 ALOX15 NOTCH1 PTPN11 GPBAR1 NDRG4 FGF8 PTK2B CD74 BMP4 CHRNA7 ADRA1A NECAB2 SLC30A10 NRP1 NOX4 PDGFRB OR2AT4 S100A7 FPR2 PDE8A IL26 MTURN MFAP3 DENND2B IGF1 CARD9 CD44 TLR4 DDR2 FGF23 AGER URS0000183BED_9606 FGFR3 CRKL TIRAP TNFSF11 RAP1A DRD2 TRPV4 ABL1 PHB1 MAP2K7 ACTA2 SPRY2 NPSR1 NPNT TNF EPO AKAP12 TREM2 FGF10 OPRM1 SHC1 PTPN22 GCNT2 NODAL amy3-receptor_human ROR1 PLA2G2A CALCR SLAMF1 SCIMP HRAS P2RY1 GLIPR2 FGB MOS TEK URS0000298BA3_9606 FGFR2 HTR2C TPBG CAVIN3 HTR2A HCRTR1 MAP3K12

positive regulation of ERK1 and ERK2 cascade

I. Involved cell-cell interactions

II. Literature review