CD36 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	29 studies	38% ± 20%	Explore
classical monocyte	27 studies	47% ± 16%	Explore
endothelial cell	24 studies	39% ± 18%	Explore
monocyte	23 studies	32% ± 13%	Explore
endothelial cell of lymphatic vessel	22 studies	49% ± 18%	Explore
plasmacytoid dendritic cell	16 studies	32% ± 11%	Explore
non-classical monocyte	14 studies	25% ± 10%	Explore
conventional dendritic cell	13 studies	28% ± 14%	Explore
capillary endothelial cell	13 studies	50% ± 15%	Explore
type II pneumocyte	12 studies	31% ± 15%	Explore
pericyte	11 studies	53% ± 25%	Explore
endothelial cell of artery	10 studies	31% ± 14%	Explore
adipocyte	10 studies	70% ± 18%	Explore
dendritic cell	8 studies	30% ± 13%	Explore
vein endothelial cell	8 studies	30% ± 11%	Explore
myeloid cell	8 studies	49% ± 20%	Explore
smooth muscle cell	7 studies	40% ± 19%	Explore
erythrocyte	7 studies	50% ± 19%	Explore
platelet	6 studies	28% ± 10%	Explore
cardiac muscle cell	6 studies	78% ± 15%	Explore
mononuclear phagocyte	5 studies	31% ± 9%	Explore
endothelial cell of sinusoid	5 studies	48% ± 25%	Explore
erythroblast	5 studies	43% ± 19%	Explore
fibroblast	5 studies	36% ± 12%	Explore
alveolar macrophage	4 studies	22% ± 3%	Explore
leukocyte	4 studies	26% ± 11%	Explore
intermediate monocyte	4 studies	42% ± 17%	Explore
endothelial cell of vascular tree	4 studies	50% ± 15%	Explore
pancreatic A cell	3 studies	26% ± 3%	Explore
epithelial cell	3 studies	26% ± 5%	Explore
tissue-resident macrophage	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	19% ± 4%	Explore
peripheral blood	7 studies	21% ± 3%	Explore
heart	6 studies	48% ± 13%	Explore
adipose	4 studies	39% ± 19%	Explore
liver	4 studies	37% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	97%	56858.91	445 / 459	80%	28.69	895 / 1118
thymus	95%	7895.91	623 / 653	68%	10.47	414 / 605
lung	79%	5074.90	455 / 578	62%	7.49	717 / 1155
adipose	100%	73498.33	1204 / 1204	0%	0	0 / 0
spleen	100%	13811.36	240 / 241	0%	0	0 / 0
heart	100%	23384.02	857 / 861	0%	0	0 / 0
muscle	93%	8454.65	747 / 803	0%	0	0 / 0
adrenal gland	14%	754.71	36 / 258	68%	17.07	156 / 230
liver	2%	69.23	4 / 226	79%	18.65	319 / 406
skin	23%	1307.38	421 / 1809	55%	10.99	260 / 472
esophagus	36%	1754.02	522 / 1445	39%	5.08	71 / 183
kidney	2%	118.60	2 / 89	69%	31.73	624 / 901
pancreas	5%	194.37	17 / 328	66%	13.88	118 / 178
stomach	28%	1320.02	102 / 359	35%	3.34	100 / 286
intestine	38%	2111.95	367 / 966	24%	2.44	124 / 527
bladder	19%	1109.67	4 / 21	40%	12.47	203 / 504
lymph node	0%	0	0 / 0	34%	2.68	10 / 29
peripheral blood	34%	1974.67	320 / 929	0%	0	0 / 0
uterus	0%	0	0 / 170	30%	12.76	138 / 459
ovary	1%	39.19	2 / 180	27%	2.07	115 / 430
blood vessel	28%	2474.21	370 / 1335	0%	0	0 / 0
prostate	2%	77.92	4 / 245	14%	0.95	71 / 502
brain	1%	30.55	18 / 2642	12%	1.16	87 / 705
tonsil	0%	0	0 / 0	11%	0.73	5 / 45
eye	0%	0	0 / 0	3%	0.22	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0097009	Biological process	energy homeostasis
GO_0031623	Biological process	receptor internalization
GO_0071726	Biological process	cellular response to diacyl bacterial lipopeptide
GO_0098900	Biological process	regulation of action potential
GO_0006911	Biological process	phagocytosis, engulfment
GO_0070508	Biological process	cholesterol import
GO_0006910	Biological process	phagocytosis, recognition
GO_0044539	Biological process	long-chain fatty acid import into cell
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0060100	Biological process	positive regulation of phagocytosis, engulfment
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0015912	Biological process	short-chain fatty acid transport
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0071447	Biological process	cellular response to hydroperoxide
GO_0070542	Biological process	response to fatty acid
GO_0070543	Biological process	response to linoleic acid
GO_0000165	Biological process	MAPK cascade
GO_0010629	Biological process	negative regulation of gene expression
GO_0038060	Biological process	nitric oxide-cGMP-mediated signaling
GO_0010628	Biological process	positive regulation of gene expression
GO_0042308	Biological process	negative regulation of protein import into nucleus
GO_1903428	Biological process	positive regulation of reactive oxygen species biosynthetic process
GO_0007155	Biological process	cell adhesion
GO_0034197	Biological process	triglyceride transport
GO_0006631	Biological process	fatty acid metabolic process
GO_0043277	Biological process	apoptotic cell clearance
GO_0033993	Biological process	response to lipid
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0019915	Biological process	lipid storage
GO_0071223	Biological process	cellular response to lipoteichoic acid
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0030194	Biological process	positive regulation of blood coagulation
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0042953	Biological process	lipoprotein transport
GO_0006629	Biological process	lipid metabolic process
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0010744	Biological process	positive regulation of macrophage derived foam cell differentiation
GO_0019934	Biological process	cGMP-mediated signaling
GO_0015909	Biological process	long-chain fatty acid transport
GO_0010886	Biological process	positive regulation of cholesterol storage
GO_0150024	Biological process	oxidised low-density lipoprotein particle clearance
GO_0055096	Biological process	low-density lipoprotein particle mediated signaling
GO_0007596	Biological process	blood coagulation
GO_0050909	Biological process	sensory perception of taste
GO_2000121	Biological process	regulation of removal of superoxide radicals
GO_0032731	Biological process	positive regulation of interleukin-1 beta production
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0150094	Biological process	amyloid-beta clearance by cellular catabolic process
GO_0050892	Biological process	intestinal absorption
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_0043254	Biological process	regulation of protein-containing complex assembly
GO_0031664	Biological process	regulation of lipopolysaccharide-mediated signaling pathway
GO_2000334	Biological process	positive regulation of blood microparticle formation
GO_0034121	Biological process	regulation of toll-like receptor signaling pathway
GO_1904646	Biological process	cellular response to amyloid-beta
GO_0140052	Biological process	cellular response to oxidised low-density lipoprotein particle stimulus
GO_0030301	Biological process	cholesterol transport
GO_0030299	Biological process	intestinal cholesterol absorption
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0034381	Biological process	plasma lipoprotein particle clearance
GO_0035634	Biological process	response to stilbenoid
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0015911	Biological process	long-chain fatty acid import across plasma membrane
GO_0016525	Biological process	negative regulation of angiogenesis
GO_1900227	Biological process	positive regulation of NLRP3 inflammasome complex assembly
GO_0015908	Biological process	fatty acid transport
GO_1990000	Biological process	amyloid fibril formation
GO_0002532	Biological process	production of molecular mediator involved in inflammatory response
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0034383	Biological process	low-density lipoprotein particle clearance
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_1990379	Biological process	lipid transport across blood-brain barrier
GO_0035579	Cellular component	specific granule membrane
GO_0045121	Cellular component	membrane raft
GO_0009986	Cellular component	cell surface
GO_0071944	Cellular component	cell periphery
GO_0045335	Cellular component	phagocytic vesicle
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005737	Cellular component	cytoplasm
GO_0005901	Cellular component	caveola
GO_0031526	Cellular component	brush border membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0031092	Cellular component	platelet alpha granule membrane
GO_0150025	Molecular function	oxidised low-density lipoprotein particle receptor activity
GO_0071813	Molecular function	lipoprotein particle binding
GO_0015636	Molecular function	short-chain fatty acid transmembrane transporter activity
GO_0005324	Molecular function	long-chain fatty acid transmembrane transporter activity
GO_0035325	Molecular function	Toll-like receptor binding
GO_0038024	Molecular function	cargo receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0050431	Molecular function	transforming growth factor beta binding
GO_0070053	Molecular function	thrombospondin receptor activity
GO_0008289	Molecular function	lipid binding
GO_0005041	Molecular function	low-density lipoprotein particle receptor activity
GO_0030169	Molecular function	low-density lipoprotein particle binding
GO_0008035	Molecular function	high-density lipoprotein particle binding
GO_0005515	Molecular function	protein binding
GO_1901480	Molecular function	oleate transmembrane transporter activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0070892	Molecular function	lipoteichoic acid immune receptor activity
GO_0005044	Molecular function	scavenger receptor activity

IV. Literature review

[source]

Gene name	CD36
Protein name	Platelet glycoprotein 4 (Glycoprotein IIIb) (PAS IV) (PAS-4) (Platelet glycoprotein IV) Mutant thrombospondin receptor Thrombospondin receptor Platelet glycoprotein 4 CD36 molecule Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36) CD36 antigen
Synonyms	GP4 hCG_17062 tcag7.257 GP3B
Description	FUNCTION: Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) . Mechanistically, binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36 and caveolar endocytosis . In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) . Involved in oral fat perception and preferences . Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting together with THBS1 (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) . Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) . .; FUNCTION: (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. .
Accessions	A0A0H3WDH4 A0A0H3WE82 A4D1B1 A0A516AFI0 A0A0A1EAI1 A0A0G3VR70 A0A2D1WBA2 ENST00000436384.5 ENST00000534394.5 E7EU05 ENST00000438020.5 H0YEE7 ENST00000544133.5 [P16671-2] ENST00000441034.2 A0A0G3VPD9 A0A0H3WBE8 E9PC45 Q13965 V5M404 ENST00000433696.6 [P16671-3] ENST00000488048.1 ENST00000419819.2 ENST00000426978.5 A0A0G3VSQ7 E7ERZ9 ENST00000394788.7 [P16671-1] A0A0G3VRE1 ENST00000482059.6 A0A0G3VQ57 ENST00000447544.7 [P16671-1] D9IX65 A0A0S2Z3J6 E9PLT1 ENST00000428497.5 E7EX47 ENST00000432207.5 [P16671-1] A0A0S2Z452 E7EWI4 D9IX64 ENST00000538969.5 [P16671-4] ENST00000413265.5 ENST00000309881.11 [P16671-1] P16671 ENST00000435819.5 [P16671-1] E7EVU1 A0A0H3WC42 A0A0H3WDK6 E9PJX8 A0A0A1ED81 D9IX63

CD36 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review