GO_0010629 | OmnibusX

negative regulation of gene expression

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	APLN-APLNR	APEL_HUMAN - APJ_HUMAN	Ligand-Receptor	Signaling by Apelin
2	BMP2-ACVR2A+BMPR1A	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
3	BMP2-ACVR2B+BMPR1A	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
4	BMP2-BMPR1A+BMPR2	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
5	BMP4-ACVR2A+BMPR1A	BMP4_HUMAN -	Ligand-Receptor	Signaling by BMP
6	BMP4-ACVR2B+BMPR1A	BMP4_HUMAN -	Ligand-Receptor	Signaling by BMP
7	BMP4-BMPR1A+BMPR2	BMP4_HUMAN -	Ligand-Receptor	Signaling by BMP
8	CCL3-CCR1	CCL3_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
9	DLL4-NOTCH1	DLL4_HUMAN - NOTC1_HUMAN	Ligand-Receptor	Signaling by Notch
10	DLL4-NOTCH2	DLL4_HUMAN - NOTC2_HUMAN	Ligand-Receptor	Signaling by Notch
11	LGALS9-HAVCR2	LEG9_HUMAN - HAVR2_HUMAN	Ligand-Receptor	Signaling by Galectin
12	VEGFA-FLT1+KDR	VEGFA_HUMAN -	Ligand-Receptor	Signaling by Vascular endothelial growth factor
13	VEGFA-KDR	VEGFA_HUMAN - VGFR2_HUMAN	Ligand-Receptor	Signaling by Vascular endothelial growth factor
14	WNT4-SFRP1	WNT4_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
15	WNT4-SFRP2	WNT4_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition

II. Literature review

Name	negative regulation of gene expression
ID	GO_0010629
collection_id	Biological process
Description	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
Related synonym	gene silencing
Comment	This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
External URL
Genes	URS00003AD7BA_9606 GATA2 URS0000554A4F_9606 DAXX INS BAK1 TRIM6 RCOR1 FERMT1 URS000040DCFF_9606 NOTCH2 CLDN5 IFNA2 ACVRL1 URS00025AC1D4_9606 CD36 TBK1 URS00006696FA_9606 URS000034B6F5_9606 SRC ADAM10 URS0000689450_9606 BMPR1A TGIF1 URS00001C308D_9606 NRXN1 NDFIP1 DDX3Y URS00002E857A_9606 PSEN1 MSX1 AKIRIN2 URS000066E659_9606 URS00003B95DA_9606 AURKA PRKN TP53INP1 PLA2G3 MIF TAF1 TLE5 CD46 GATA5 URS00006A3BBF_9606 URS00001230A0_9606 DLL4 URS000050B527_9606 SMAD5 CPNE1 VEGFA NFKB1 NDFIP2 URS00025C2850_9606 TIPARP SMAD3 MECP2 RBMS3 SERPINF1 EMILIN1 ZBTB7B URS00003FF9A8_9606 PINK1 LGMN URS0000DB73A2_9606 URS00005A4DCF_9606 URS00006C9C0E_9606 URS000026261D_9606 URS00004176D4_9606 URS0002232766_9606 URS000040D674_9606 URS00004208C5_9606 CDK1 CRH ZNF808 abeta-42_human SLC35C2 ATP2B4 URS00006719B4_9606 ENG URS0000D5A723_9606 SFRP1 DIP2A VHL BBS4 APP FYN ID3 OCLN GGNBP2 HMGB2 PARK7 URS000255DCBB_9606 ACE DICER1 URS000058BB84_9606 FOXP1 URS0000149452_9606 CITED2 URS0000460483_9606 HEYL TERT FGF2 TERF2 URS00000254A6_9606 URS00003DA300_9606 URS0000DBB703_9606 URS0000DB895B_9606 HEY2 CREB3L1 AXIN1 URS00001D6BAE_9606 ID2 ACVR1B PPARG LRP1 URS000250A57F_9606 TGFB1 URS00003F4546_9606 PTH TGFB2 ITGB8 APOE URS0000080A09_9606 URS00006054DA_9606 URS00008B60CF_9606 URS00004023EA_9606 URS000250C4BF_9606 NOS2 RACK1 AKT1 URS00000A68B2_9606 URS00008BA5DE_9606 TCEAL1 URS0000732D5D_9606 URS00002C11C3_9606 ATOH8 NOTCH1 PDCD10 URS0000574A2C_9606 MEF2C TMF1 URS000024A59E_9606 URS00002075FA_9606 VPS35 MSR1 URS0000527228_9606 MKKS NOG CD34 OLFM1 RB1 IGF1 URS0000EBF5B3_9606 OPRD1 URS000020BE6A_9606 CHD4 URS0000D5D3B0_9606 BBS2 UCN URS0000028BB8_9606 REST MYADM ZNF281 HES1 ANAPC2 ZBTB20 URS000258A127_9606 LRP3 FBXW7 PRKAA1 ABCC2 SHH SH3GL2 PGR CDKN1A PPP3CA CD28 CCN2 DNMT1 NOCT HIF1A ANXA7 SFMBT2 SIRT1 URS00001F5B39_9606 URS000014D9C1_9606 URS0000497496_9606 URS000006FDD4_9606 IQGAP3 SFRP2 URS0000614A9B_9606 PTRH2 CNPY2 YAP1 GSK3B PPP2CB HSF1 URS00002E177F_9606 STAT3 SETDB2 NTS URS00003768C5_9606 ESR1 RBL2 URS0000DB8B93_9606 URS0000446722_9606 BMP2 XDH URS000039ED8D_9606 CRYAB CCDC3 CILP POU3F2 CD3E KDR SLC7A5 CXCL8 AFF2 EPM2A SPI1 SLC24A3 URS0000D5D441_9606 CNOT7 WNT4 GPER1 FGF19 URS0002536590_9606 PARP14 ROBO1 BMP4 ZNF148 URS00008BC177_9606 CHMP1A PRKAR1A URS0000535FDD_9606 REL MAP3K7 SMCR8 SLC2A10 URS0000323138_9606 MAPT SNX12 URS0000209905_9606 CRKL SOX11 APLNR abeta-40-42-oligomer_human TNF URS0000675522_9606 SMO URS000030BD69_9606 URS000013D17D_9606 TARDBP KLF4 SLIT3 ZNF503 CLDN19 URS0000725A1B_9606 PARP10 HINFP HRAS URS00007333DC_9606 HNRNPD ERP29 LDLR URS000009262D_9606 URS00023433EC_9606 HAND2 URS00007228B9_9606 ZNF410 PRKAA2 URS00000B772E_9606 URS0000483184_9606 STOX1 MARK1 CCL3 APLN PICALM URS00004AE8D3_9606 ZC3H12A HDAC1 URS000059311D_9606 IFNG TFAP4 URS00009B2603_9606 URS000019D79B_9606 PARP9 FLOT2 PIK3CA PDGFB RNASEH2B URS0000D5A667_9606 PLAG1 NR0B2 STC2 GJA1 URS000049A7EB_9606 URS000001C659_9606 CLDN3 URS0000272A3D_9606 TTBK1 CCR1 ROCK2 URS00025110B6_9606 INPPL1 URS0000D5A4BB_9606 URS0000528CBC_9606 WWP2 PRDM1 POU4F1 KDM4A URS0000568FF8_9606 SETDB1 PAWR ACACB HAVCR2 URS00008BCDA9_9606 MBD1 URS0000D54CAD_9606 YY1 URS000037C5A8_9606 URS0000338542_9606 LGALS9 URS00003FE4D4_9606 SOX9 URS00008BCA0B_9606 URS00008BC726_9606 RBL1 CELF1 URS00001B341F_9606 UPK3B ADNP URS000024463E_9606 DDX3X URS00004449AE_9606 URS00002367FA_9606 URS0000DB7858_9606 URS0000424278_9606 URS00025443D2_9606 URS0000183BED_9606 PC OVOL2 URS00004E0808_9606 URS00002F4D78_9606 EDN1 CTNNB1 DGKQ PTPN22 KPNA7 URS000032599B_9606 PARP15 DDRGK1 NKX3-1 URS0000D5B884_9606 MYCN PIAS3 BRIP1