Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| brain | 19 studies | 48% ± 20% | |
| peripheral blood | 15 studies | 29% ± 10% | |
| lung | 9 studies | 22% ± 5% | |
| eye | 5 studies | 30% ± 13% | |
| heart | 4 studies | 23% ± 3% | |
| uterus | 4 studies | 19% ± 2% | |
| adipose | 4 studies | 39% ± 14% | |
| bone marrow | 3 studies | 27% ± 1% | |
| intestine | 3 studies | 23% ± 0% | |
| liver | 3 studies | 32% ± 8% | |
| lymph node | 3 studies | 27% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 8891.45 | 2642 / 2642 | 100% | 184.70 | 704 / 705 |
| thymus | 100% | 5102.22 | 652 / 653 | 99% | 72.78 | 601 / 605 |
| skin | 100% | 5051.39 | 1804 / 1809 | 99% | 52.22 | 468 / 472 |
| lung | 100% | 7786.44 | 578 / 578 | 80% | 17.43 | 928 / 1155 |
| breast | 100% | 5875.24 | 458 / 459 | 74% | 14.33 | 830 / 1118 |
| ovary | 100% | 3350.08 | 180 / 180 | 73% | 20.05 | 315 / 430 |
| kidney | 99% | 2728.31 | 88 / 89 | 72% | 23.06 | 653 / 901 |
| stomach | 97% | 2989.52 | 348 / 359 | 62% | 13.36 | 176 / 286 |
| intestine | 99% | 4133.58 | 958 / 966 | 55% | 11.17 | 291 / 527 |
| uterus | 99% | 5654.96 | 169 / 170 | 54% | 15.45 | 248 / 459 |
| bladder | 100% | 5895.33 | 21 / 21 | 51% | 10.64 | 255 / 504 |
| esophagus | 85% | 2348.11 | 1234 / 1445 | 61% | 10.77 | 111 / 183 |
| prostate | 91% | 2240.92 | 224 / 245 | 18% | 2.34 | 92 / 502 |
| pancreas | 13% | 172.73 | 41 / 328 | 92% | 21.40 | 164 / 178 |
| adipose | 100% | 8939.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 8243.51 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 98% | 2927.46 | 843 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 97% | 2930.69 | 1292 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 32.18 | 76 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 45.92 | 27 / 29 |
| adrenal gland | 26% | 387.70 | 67 / 258 | 67% | 21.87 | 153 / 230 |
| liver | 62% | 911.29 | 140 / 226 | 30% | 4.48 | 121 / 406 |
| peripheral blood | 91% | 4824.58 | 842 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 76% | 13.48 | 34 / 45 |
| muscle | 26% | 394.52 | 206 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0048013 | Biological process | ephrin receptor signaling pathway |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_1904645 | Biological process | response to amyloid-beta |
| GO_0001764 | Biological process | neuron migration |
| GO_0002862 | Biological process | negative regulation of inflammatory response to antigenic stimulus |
| GO_1905430 | Biological process | cellular response to glycine |
| GO_0050730 | Biological process | regulation of peptidyl-tyrosine phosphorylation |
| GO_0050900 | Biological process | leukocyte migration |
| GO_0003015 | Biological process | heart process |
| GO_0030163 | Biological process | protein catabolic process |
| GO_0050798 | Biological process | activated T cell proliferation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0042177 | Biological process | negative regulation of protein catabolic process |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0007612 | Biological process | learning |
| GO_0045087 | Biological process | innate immune response |
| GO_0030900 | Biological process | forebrain development |
| GO_0031295 | Biological process | T cell costimulation |
| GO_0007411 | Biological process | axon guidance |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0090314 | Biological process | positive regulation of protein targeting to membrane |
| GO_0097062 | Biological process | dendritic spine maintenance |
| GO_0010467 | Biological process | gene expression |
| GO_1902951 | Biological process | negative regulation of dendritic spine maintenance |
| GO_1905232 | Biological process | cellular response to L-glutamate |
| GO_0036120 | Biological process | cellular response to platelet-derived growth factor stimulus |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_1900449 | Biological process | regulation of glutamate receptor signaling pathway |
| GO_0048813 | Biological process | dendrite morphogenesis |
| GO_0050966 | Biological process | detection of mechanical stimulus involved in sensory perception of pain |
| GO_0007216 | Biological process | G protein-coupled glutamate receptor signaling pathway |
| GO_0045471 | Biological process | response to ethanol |
| GO_0002223 | Biological process | stimulatory C-type lectin receptor signaling pathway |
| GO_2001056 | Biological process | positive regulation of cysteine-type endopeptidase activity |
| GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0000304 | Biological process | response to singlet oxygen |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_1905664 | Biological process | regulation of calcium ion import across plasma membrane |
| GO_0007631 | Biological process | feeding behavior |
| GO_1902176 | Biological process | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_1905477 | Biological process | positive regulation of protein localization to membrane |
| GO_0030154 | Biological process | cell differentiation |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0010730 | Biological process | negative regulation of hydrogen peroxide biosynthetic process |
| GO_0038096 | Biological process | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
| GO_0031397 | Biological process | negative regulation of protein ubiquitination |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0045121 | Cellular component | membrane raft |
| GO_0005768 | Cellular component | endosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0030425 | Cellular component | dendrite |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0043204 | Cellular component | perikaryon |
| GO_0097038 | Cellular component | perinuclear endoplasmic reticulum |
| GO_0005884 | Cellular component | actin filament |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0097386 | Cellular component | glial cell projection |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0044297 | Cellular component | cell body |
| GO_0016004 | Molecular function | phospholipase activator activity |
| GO_0046875 | Molecular function | ephrin receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0048156 | Molecular function | tau protein binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0070851 | Molecular function | growth factor receptor binding |
| GO_0043274 | Molecular function | phospholipase binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0050321 | Molecular function | tau-protein kinase activity |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0031802 | Molecular function | type 5 metabotropic glutamate receptor binding |
| GO_0043014 | Molecular function | alpha-tubulin binding |
| GO_0097718 | Molecular function | disordered domain specific binding |
| Gene name | FYN |
| Protein name | FYN proto-oncogene, Src family tyrosine kinase Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) FYN protein |
| Synonyms | |
| Description | FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). . |
| Accessions | E5RK23 ENST00000368678.8 [P06241-2] P06241 ENST00000523570.5 E5RJX7 ENST00000523574.5 E5RH71 ENST00000368682.8 [P06241-2] ENST00000368667.6 [P06241-1] E5RGM6 E5RFM0 E5RFS5 ENST00000520518.5 ENST00000518630.5 E5RI25 ENST00000487824.2 Q14342 E5RHF7 P78484 E5RFM4 ENST00000462598.7 ENST00000521062.5 ENST00000462856.6 ENST00000518295.5 ENST00000517419.5 ENST00000229471.8 [P06241-3] ENST00000354650.7 [P06241-1] E5RFM6 ENST00000524310.5 E5RIX5 E5RGT0 E5RHX7 ENST00000523238.5 ENST00000484067.6 |
