Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | PGF-FLT1 | PLGF_HUMAN - VGFR1_HUMAN | Ligand-Receptor | Signaling by Placenta growth factor |
| 2 | PGF-FLT1+KDR | PLGF_HUMAN - | Ligand-Receptor | Signaling by Placenta growth factor |
| 3 | PGF-NRP1 | PLGF_HUMAN - NRP1_HUMAN | Ligand-Receptor | Signaling by Placenta growth factor |
| 4 | VEGFA-FLT1 | VEGFA_HUMAN - VGFR1_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 5 | VEGFA-FLT1+KDR | VEGFA_HUMAN - | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 6 | VEGFA-KDR | VEGFA_HUMAN - VGFR2_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 7 | VEGFA-NRP1 | VEGFA_HUMAN - NRP1_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 8 | VEGFB-FLT1 | VEGFB_HUMAN - VGFR1_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 9 | VEGFB-FLT1+KDR | VEGFB_HUMAN - | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 10 | VEGFB-NRP1 | VEGFB_HUMAN - NRP1_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 11 | VEGFC-FLT4 | VEGFC_HUMAN - VGFR3_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 12 | VEGFC-KDR | VEGFC_HUMAN - VGFR2_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 13 | VEGFD-FLT4 | VEGFD_HUMAN - VGFR3_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| 14 | VEGFD-KDR | VEGFD_HUMAN - VGFR2_HUMAN | Ligand-Receptor | Signaling by Vascular endothelial growth factor |
| Name | vascular endothelial growth factor receptor signaling pathway |
| ID | GO_0048010 |
| collection_id | Biological process |
| Exact synonym | VEGF receptor signaling pathway, VEGF receptor signalling pathway, VEGFR signaling pathway |
| Description | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Comment | In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. |
| External URL | |
| Genes |