FOXC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXC1 at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0046620Biological processregulation of organ growth
GO_0048844Biological processartery morphogenesis
GO_0001525Biological processangiogenesis
GO_0001657Biological processureteric bud development
GO_0072010Biological processglomerular epithelium development
GO_0001974Biological processblood vessel remodeling
GO_1904798Biological processpositive regulation of core promoter binding
GO_0008283Biological processcell population proliferation
GO_0007219Biological processNotch signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0048341Biological processparaxial mesoderm formation
GO_0007507Biological processheart development
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001541Biological processovarian follicle development
GO_0032808Biological processlacrimal gland development
GO_0010628Biological processpositive regulation of gene expression
GO_0001822Biological processkidney development
GO_0001958Biological processendochondral ossification
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0097746Biological processblood vessel diameter maintenance
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0001654Biological processeye development
GO_0014032Biological processneural crest cell development
GO_0055010Biological processventricular cardiac muscle tissue morphogenesis
GO_0003275Biological processapoptotic process involved in outflow tract morphogenesis
GO_0016525Biological processnegative regulation of angiogenesis
GO_1901491Biological processnegative regulation of lymphangiogenesis
GO_0014031Biological processmesenchymal cell development
GO_0060038Biological processcardiac muscle cell proliferation
GO_0030203Biological processglycosaminoglycan metabolic process
GO_1901534Biological processpositive regulation of hematopoietic progenitor cell differentiation
GO_1902038Biological processpositive regulation of hematopoietic stem cell differentiation
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0036438Biological processmaintenance of lens transparency
GO_0030154Biological processcell differentiation
GO_0035050Biological processembryonic heart tube development
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001756Biological processsomitogenesis
GO_0043388Biological processpositive regulation of DNA binding
GO_0009653Biological processanatomical structure morphogenesis
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0021549Biological processcerebellum development
GO_1990869Biological processcellular response to chemokine
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0043010Biological processcamera-type eye development
GO_0030199Biological processcollagen fibril organization
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0001945Biological processlymph vessel development
GO_1902257Biological processnegative regulation of apoptotic process involved in outflow tract morphogenesis
GO_0008354Biological processgerm cell migration
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0016477Biological processcell migration
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0008301Molecular functionDNA binding, bending
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXC1
Protein nameForkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)
Forkhead box C1
FOXC1 protein
SynonymsFKHL7
hCG_21926
FREAC3
DescriptionFUNCTION: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development . Acts either as a transcriptional activator or repressor . Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes . Upon DNA-binding, promotes DNA bending . Acts as a transcriptional coactivator . Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells . Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye . Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals . Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion . Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation . Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor . .

AccessionsENST00000645831.2
A3KPE3
Q12948
C6KMR8
W6CJ52