SULF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	21 studies	27% ± 12%	Explore
mesothelial cell	10 studies	48% ± 23%	Explore
endothelial cell of artery	7 studies	34% ± 18%	Explore
Mueller cell	6 studies	55% ± 14%	Explore
connective tissue cell	5 studies	36% ± 15%	Explore
smooth muscle cell	5 studies	21% ± 4%	Explore
GABAergic neuron	4 studies	27% ± 7%	Explore
podocyte	4 studies	42% ± 16%	Explore
endothelial cell	4 studies	37% ± 17%	Explore
retinal pigment epithelial cell	3 studies	50% ± 24%	Explore
adventitial cell	3 studies	22% ± 2%	Explore
astrocyte	3 studies	28% ± 16%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SULF1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	85%	2680.31	390 / 459	95%	121.73	1064 / 1118
prostate	96%	7850.32	235 / 245	75%	32.66	375 / 502
thymus	99%	6229.26	645 / 653	69%	34.85	416 / 605
intestine	83%	7458.14	804 / 966	80%	77.20	424 / 527
lung	72%	2035.36	416 / 578	87%	72.67	1001 / 1155
esophagus	75%	3008.27	1081 / 1445	77%	62.23	140 / 183
uterus	90%	4845.16	153 / 170	58%	38.45	265 / 459
kidney	80%	2437.07	71 / 89	60%	34.65	537 / 901
ovary	72%	2119.32	130 / 180	67%	46.54	286 / 430
bladder	62%	2370.57	13 / 21	63%	49.55	317 / 504
stomach	30%	758.44	108 / 359	83%	81.00	238 / 286
blood vessel	100%	23804.65	1335 / 1335	0%	0	0 / 0
pancreas	2%	69.34	8 / 328	89%	154.24	159 / 178
adipose	89%	5419.02	1072 / 1204	0%	0	0 / 0
skin	37%	4373.23	665 / 1809	49%	28.95	230 / 472
tonsil	0%	0	0 / 0	62%	35.07	28 / 45
heart	51%	1629.81	442 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	21.18	14 / 29
brain	8%	152.13	204 / 2642	36%	16.14	252 / 705
adrenal gland	2%	54.79	6 / 258	18%	5.41	42 / 230
liver	0%	7.38	1 / 226	18%	7.02	74 / 406
eye	0%	0	0 / 0	4%	1.46	3 / 80
muscle	3%	75.25	28 / 803	0%	0	0 / 0
spleen	1%	25.28	3 / 241	0%	0	0 / 0
peripheral blood	0%	14.21	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0003094	Biological process	glomerular filtration
GO_0035860	Biological process	glial cell-derived neurotrophic factor receptor signaling pathway
GO_0014846	Biological process	esophagus smooth muscle contraction
GO_0001822	Biological process	kidney development
GO_0032836	Biological process	glomerular basement membrane development
GO_0030201	Biological process	heparan sulfate proteoglycan metabolic process
GO_0002063	Biological process	chondrocyte development
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0001937	Biological process	negative regulation of endothelial cell proliferation
GO_0048706	Biological process	embryonic skeletal system development
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0060686	Biological process	negative regulation of prostatic bud formation
GO_0010575	Biological process	positive regulation of vascular endothelial growth factor production
GO_0006915	Biological process	apoptotic process
GO_0048010	Biological process	vascular endothelial growth factor receptor signaling pathway
GO_0030336	Biological process	negative regulation of cell migration
GO_0040036	Biological process	regulation of fibroblast growth factor receptor signaling pathway
GO_0060348	Biological process	bone development
GO_0060384	Biological process	innervation
GO_0051216	Biological process	cartilage development
GO_0040037	Biological process	negative regulation of fibroblast growth factor receptor signaling pathway
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0005795	Cellular component	Golgi stack
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0005794	Cellular component	Golgi apparatus
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0009986	Cellular component	cell surface
GO_0005783	Cellular component	endoplasmic reticulum
GO_0004065	Molecular function	arylsulfatase activity
GO_0005539	Molecular function	glycosaminoglycan binding
GO_0005509	Molecular function	calcium ion binding
GO_0008449	Molecular function	N-acetylglucosamine-6-sulfatase activity

IV. Literature review

[source]

Gene name	SULF1
Protein name	Sulfatase 1 SULF1 protein Extracellular sulfatase Sulf-1 (hSulf-1) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]
Synonyms	KIAA1077
Description	FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity . It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin . Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation . .
Accessions	ENST00000534179.5 E9PLS5 Q96E28 E9PS14 ENST00000528783.5 ENST00000525999.5 ENST00000616868.1 A0A087WWR8 ENST00000529134.5 Q8IWU6 H0YDR1 ENST00000419716.7 ENST00000402687.9 ENST00000525061.5 E9PJL8 ENST00000531512.5 E9PI06 ENST00000458141.6 Q6NUJ9 ENST00000260128.8 E9PPQ3

SULF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review