GO_0062023 | OmnibusX

collagen-containing extracellular matrix

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	FGF10-FGFR2	FGF10_HUMAN - FGFR2_HUMAN	Ligand-Receptor	Signaling by Fibroblast growth factor
2	L1CAM-EZR+L1CAM	L1CAM_HUMAN -	Ligand-Receptor	Adhesion by L1CAM
3	NCAM1-AGRN	NCAM1_HUMAN - AGRIN_HUMAN	Ligand-Receptor	Signaling by Leucine-Rich Repeat Transmembrane Neuronal Protein
4	SHH-CDON+PTCH1	SHH_HUMAN -	Ligand-Receptor	Signaling by Sonic hedgehog
5	SHH-CDON+PTCH2	SHH_HUMAN -	Ligand-Receptor	Signaling by Sonic hedgehog
6	WNT2-SFRP1	WNT2_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
7	WNT2-SFRP2	WNT2_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
8	WNT2B-SFRP1	WNT2B_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
9	WNT2B-SFRP2	WNT2B_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
10	WNT5A-SFRP1	WNT5A_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
11	WNT5A-SFRP2	WNT5A_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
12	WNT5B-SFRP1	WNT5B_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
13	WNT5B-SFRP2	WNT5B_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
14	WNT8A-SFRP1	WNT8A_HUMAN - SFRP1_HUMAN	Ligand-Ligand	Signaling by WNT inhibition
15	WNT8A-SFRP2	WNT8A_HUMAN - SFRP2_HUMAN	Ligand-Ligand	Signaling by WNT inhibition

II. Literature review

Name	collagen-containing extracellular matrix
ID	GO_0062023
collection_id	Cellular component
Description	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
External URL
Genes	ANXA8 COL4A3 DPT INHBE CPA3 LTBP3 PRG4 TGM4 SERPINA3 multimerin2_human IGFBP7 ZG16 THBS1 tenascin-x_human HMCN2 ANXA11 SPP2 SERPINB8 CALR OGN IFNA2 COL9A2 OTOL1 AMBP P3H1 CLEC3B GDF10 PZP GREM1 WNT8A MFGE8 COL26A1 CCN1 LGALS1 CTSF COL4A1 GPC3 ASPN ADAMTS10 LRRC15 SLPI SBSPON A1BG CLEC14A C1QB KNG1 DEFA1 PLOD3 FN1 ELN L1CAM LTBP2 COL5A1 ECM1 APCS VWA1 COL8A2 CDH13 MXRA7 ORM1 matrilin2_human LAMA1 S100A7 TNN FCN2 COL15A1 SERPINF1 COL24A1 ANGPTL1 ADAMTS5 CFP COL6A2 EMILIN1 TIMP2 LGALS4 NPPA LAMC1 SOD3 CMA1 DCN COL6A1 COL22A1 matrilin1_human VCAN multimerin1_human GDF15 COL5A3 FBN2 GH1 SERPINB1 LTBP1 COL27A1 IL7 LAMA5 CDON C17orf58 LGALS3BP ANGPTL6 S100A8 GPC4 HDGF SFRP1 SERPINF2 MYOC EMILIN2 FREM2 MST1 DAG1 COL25A1 AZGP1 BMP7 LTBP4 MATN3 tgfb2_human-1 COCH TGFB1I1 CLU WNT2 COL23A1 SERPINA1 MMP23B LAMA3 TGFBI THSD4 KRT1 COL1A2 FIBCD1 ANXA5 COL4A5 MMP28 TGFB3 MMRN1 GPC2 EGFL7 LAMC2 NDP ANGPTL7 TGFB1 CSPG4 SEMA7A HSP90B1 TGFB2 COL4A6 FMOD ADAMDEC1 NID1 SULF1 APOE ANGPT1 CBLN1 VWF COL16A1 SPARC TIMP3 CTSB ORM2 ANGPT2 ITIH4 SERPINB9 emilin1_human ADAMTSL4 ELANE COL10A1 EMILIN3 MATN2 CTHRC1 FBLN1 FRAS1 COL9A1 AHSG glycoprotein-ia_human S100A4 TPSB2 HAPLN1 MATN4 SPARCL1 BCAM PSAP MFAP5 FGFBP3 PODN collagen_xi_human-1 PLG C1QC MUC2 ANGPTL5 THBS2 ZP2 FCN3 MARCOL ZP4 HRNR ANXA4 LOXL4 F2 LAMB2 MMP9 SOST SSC5D CTSD ABI3BP FBLN2 SHH FGA ANGPTL3 LGALS3 PRG2 FREM3 CCN2 MDK PCOLCE F7 ANXA7 PRG3 COL6A5 A2M COL3A1 CLC ADAMTS15 SFRP2 TPSAB1 MATN1 FBLN5 C1QA APOC3 collagen_xi_human-2 SERPINE1 ANGPT4 ITIH5 AEBP1 ZP1 COL5A2 APOH COL11A2 SERPING1 TNR LMAN1L WNT2B ANGPTL2 PF4 MGP ITIH2 TNC MMRN2 SDC3 COL6A6 FBN1 CILP SRPX LAMA2 EFEMP2 RARRES2 HRG ITIH1 LUM LOXL1 ADAMTS20 tgfb3_human-1 COL14A1 THBS4 matrilin3_human SERPINB6 CTSL HNRNPM NCAM1 LOX COMP LEFTY2 CDH2 BGN EDIL3 F3 MUC17 COL2A1 AGRN ADAM11 PLAT COL12A1 COL13A1 WNT5B CTSC COL20A1 FLG HTRA1 F12 F9 COL9A3 COLQ FCN1 MFAP2 TGM2 emilin2_human COL11A1 tenascin-r_human HPX S100A6 GPC6 CHADL HSP90AA1 ICAM1 COL7A1 POSTN PRTN3 GPC5 SRPX2 AMELX CRELD1 FGG EFEMP1 MARCO THBS3 SEMA3B vitronectin-pai-1_human COLEC12 LOXL2 ADAMTS1 MMP8 MFAP4 TNXB matrilin4_human ANGPTL4 ANXA2 COL17A1 SERPINC1 CSTB COL19A1 CCN3 PDGFB FGL2 CTSH AGT AMELY ADAMTS4 ZP3 GPC1 tgfb1_human-1 SDC2 IGFBPL1 S100A10 LAMB3 SERPINA5 ADAMTS3 TINAGL1 ADAM19 SPON1 FREM1 SNORC HSPG2 S100A9 MMP2 VTN LMAN1 CBLN4 HMCN1 ANXA6 APOA4 COL18A1 COL6A3 tenascin-c_human PKM PRSS1 SERPINB12 LOXL3 platelet-multimerin_human ADAMTS2 ADAMTS8 ANXA1 LGALS9 tenascin-w_human WNT5A COL4A4 NID2 CTSG CTSZ SERPINE2 ACAN PXDN COL8A1 MXRA5 COL21A1 APOA1 PLSCR1 PRELP ADIPOQ CTSS F13A1 PCSK6 ADAMTS9 matn1-matn3_human NPNT COL28A1 LAMA4 LAMB1 CXCL12 FGF10 FGL1 COL4A2 collagen_x_human COL1A1 FGB FGFR2 SERPINH1