CSPG4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CSPG4 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0097178Biological processruffle assembly
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0048771Biological processtissue remodeling
GO_0035556Biological processintracellular signal transduction
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0006929Biological processsubstrate-dependent cell migration
GO_0008347Biological processglial cell migration
GO_0001726Cellular componentruffle
GO_0016324Cellular componentapical plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0031258Cellular componentlamellipodium membrane
GO_0043202Cellular componentlysosomal lumen
GO_0015026Molecular functioncoreceptor activity
GO_0019901Molecular functionprotein kinase binding

IV. Literature review

[source]
Gene nameCSPG4
Protein nameCSPG4 protein
Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)
Alternative protein CSPG4
SynonymsMCSP
DescriptionFUNCTION: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. .

AccessionsENST00000308508.5
Q6UVK1
L8E9X8
A2VCL1