focal adhesion

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1CSPG4-ITGA3+ITGB1CSPG4_HUMAN - Ligand-Receptor
2ICAM1-ITGAL+ITGB2ICAM1_HUMAN - Ligand-ReceptorAdhesion by ICAM
3ICAM1-ITGAM+ITGB2ICAM1_HUMAN - Ligand-ReceptorAdhesion by ICAM
4ICAM1-ITGAX+ITGB2ICAM1_HUMAN - Ligand-ReceptorAdhesion by ICAM
5ITGAV+ITGB1-ADGRE5 - CD97_HUMANLigand-ReceptorSignaling by Integrin
6ITGAV+ITGB3-ADGRE5 - CD97_HUMANLigand-ReceptorSignaling by Integrin
7ITGAV+ITGB5-ADGRB1 - AGRB1_HUMANLigand-ReceptorSignaling by Integrin
8L1CAM-EZR+L1CAML1CAM_HUMAN - Ligand-ReceptorAdhesion by L1CAM
9L1CAM-ITGA2B+ITGB3L1CAM_HUMAN - Ligand-ReceptorAdhesion by L1CAM
10L1CAM-ITGA5+ITGB1L1CAM_HUMAN - Ligand-ReceptorAdhesion by L1CAM
11L1CAM-ITGA9+ITGB1L1CAM_HUMAN - Ligand-ReceptorAdhesion by L1CAM
12L1CAM-ITGAV+ITGB1L1CAM_HUMAN - Ligand-ReceptorAdhesion by L1CAM
13L1CAM-ITGAV+ITGB3L1CAM_HUMAN - Ligand-ReceptorAdhesion by L1CAM
14PLAU-PLAURUROK_HUMAN - UPAR_HUMANLigand-ReceptorSignaling by Plasminogen Activator
15PLAUR-ITGA4+ITGB1UPAR_HUMAN - Receptor-ReceptorSignaling by Plasminogen Activator
16PLAUR-ITGAV+ITGB3UPAR_HUMAN - Receptor-ReceptorSignaling by Plasminogen Activator
17PPIA-BSGPPIA_HUMAN - BASI_HUMANLigand-Receptor
18THY1-ADGRE5THY1_HUMAN - CD97_HUMANAdhesion-AdhesionAdhesion by antigen THY1
19THY1-ITGAM+ITGB2THY1_HUMAN - Adhesion-AdhesionAdhesion by antigen THY1
20THY1-ITGAV+ITGB3THY1_HUMAN - Adhesion-AdhesionAdhesion by antigen THY1
21THY1-ITGAX+ITGB2THY1_HUMAN - Adhesion-AdhesionAdhesion by antigen THY1
22TNC-ITGA4+ITGB1TENA_HUMAN - Ligand-ReceptorAdhesion by tenascin
23TNC-ITGA8+ITGB1TENA_HUMAN - Ligand-ReceptorAdhesion by tenascin
24TNC-ITGA9+ITGB1TENA_HUMAN - Ligand-ReceptorAdhesion by tenascin
25TNC-ITGAV+ITGB3TENA_HUMAN - Ligand-ReceptorAdhesion by tenascin
26TNC-ITGAV+ITGB6TENA_HUMAN - Ligand-ReceptorAdhesion by tenascin

II. Literature review

[source]
Namefocal adhesion
IDGO_0005925
collection_id

Cellular component

Alternative ID

GO:0005926, GO:0008357

Exact synonym

HAJ, connecting hemi-adherens junction, focal contact, hemi-adherens junction

Description

A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

Related synonym

adhesion plaque

External URL
Genes
BSGITGA2CSRP2PLECRPS5RPS3ITGA8BLOC1S6RPL7ARHGEF7PARVBMSNARF1TADA1LAP3PPIAFERMT1PEAK3DIXDC1JUPDSTFLRT1PTPRAADAM17KIF23STX16HMGA1RPS13ITGA6HSPA5RPS14CALRRPS7MMERPS8PRKAR2AAHNAKMISPRPL27G3BP1PIK3R2SRCMAPK3ADAM10CDC42TNS4CTNNA1CYFIP1DPP4TNS2EHD3YWHAQIL1RL1PARVAARMC5RPL23NUMBFLRT2PTPRCSORBS2RPS16PPFIA1PDLIM7NCSTNEVLMARCKSLMLNDCTN4L1CAMCD46KLF11LIMS2NECTIN2EPHA2RPS19CPNE3PTK7GSNCDH13RALACAP1THSD1MAP4K4CTTNCFL1CAPN2S100A7PPP1R12ACAPN5FLOT1PDIA3IGF2RIQGAP1NEXNPEAK1JAK2SHROOM4RPS10PRUNE1BCAR3CORO1CRHOBSRP68FESAKAP12ARHGAP22RPS18ARHGEF2ITGA4MRC2SDC4MAPK1MYH9RPL7ARPL19TRIOBPNFASCACTN3IRF2EPB41L2HSPB1PI4KANHERF2ENGITGBL1FLNAGNA13TWF1ARHGAP26HSPA1ADAG1KRASLIMA1RPL4SCARB2FERMT2FAPALKBH6FAM107AITGAVUSP33RPL31RPL22TGFB1I1FLRT3NCKAP1SORBS1MCAMCLASP1ITGA11ACTR3CATLIMS1PTK2PLAUXIRP2ARHGAP31SLC4A2SPRY4ABCB4ANXA5ADAM9CSRP1SNTB2YWHAZCORO2BLRP1RPS9CSPG4TNS3EPB41L5EGFRACTG1PALLDHSP90B1ILKITGA5PPP1CCITGB8ITGB3ALCAMAIF1LZNF185STARD8CBLARPC5ACTBRPL9MAP2K2EZRWASF1FZD2CD59ACTN1TSPAN9LMO7HYOU1FLT1BCAR1NHSMAPRE2RPL38PFN1PTK2BSDCBPPAK1PDLIM1ITGB7ZFYVE21CD99L2RPS17GNB2FGFR3RHOARPLP0PPIBB2MEFSCD81RPLP1CHP1RAB10GDI2GNA12VASPTEKFLIIHSPA1BRPL37ATHY1CNN1DCAF6PHLDB2VIMPDPK1ARPC2PRAG1PTPN12RPL10AAJUBAMMP14RDXTNFSF13BFHL1TNS1LAMTOR3SLC9A1PLAURALOX15BAPBB1IPADGRE5ARL2SSH2ATP6V0CJAK1FAT1ACTN4PIP5K1AITGB4CORO1BFLNCPCBP2PXNTNCRPL8RND3ARF6RPS15FHL2RPL18RPS2ATP6V0A2RPLP2GRB7RPS4XNEDD9MAPRE1RPL12CD151RPL30HSPA8ARPC1BCDH2ITGB6TESAVILSYNPO2TLN2HACD3SENP1NRP1CASKITGB1BP1SRCIN1FZD1GIT1ARHGAP24RAB21ADD1LCP1RPS11AMBRA1TRPV4TPM4DLC1CNN3TGM2SHC1CAV1RSU1ACTR2PGM5FBLN7CDC42EP1EFNB2ACTN2TSPAN4ENAHYWHAEICAM1PACSIN2XIRP1LAYNYWHAGATAT1RHOUDAB2FHL3TLE2ITGA2BSNAP23CAPN1CAV2PPP1CBTM4SF20RHOGLASP1SCARF2ADGRB1NPM1HCKRPS3APDCD6IPFLOT2P4HBPIP5K1CSVILHNRNPKLIMD1RRAS2GJA1LIMK1PABPC1DNM2CLASP2TRIP6tln1-vinc_humanNME2ARPC5LHSPG2HSPA9ITGA3SNTB1ITGB2ARPC3ANXA6FLNBMAP2K1MPRIPITGB1SH3KBP1SLC9A5CAV3PPFIBP1TLN1CD99PROCRTRIM15ANXA1CLTCMDC1LIMS3SLC6A4ASAP3FOCADSORBS3YES1FBLIM1LPXNCD9ACTC1IL16RPL5CASS4NOX4PDGFRBGAKRPL3RAC2RPL6CNN2CD44YWHABMPZL1DDR2LPPGIT2PARVGPAK4SYNE2CTNNB1RPL13APVRZYXUBOX5REXO2VCLNPHS1ITGA1AFAP1RPS29RRASGFRALDOCK7RAC1ITGB5LIMS4ARL14EP