FLOT1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	32% ± 14%	Explore
macrophage	24 studies	26% ± 8%	Explore
classical monocyte	20 studies	27% ± 9%	Explore
pericyte	20 studies	21% ± 7%	Explore
conventional dendritic cell	18 studies	29% ± 12%	Explore
natural killer cell	17 studies	23% ± 6%	Explore
fibroblast	17 studies	26% ± 13%	Explore
mast cell	16 studies	30% ± 8%	Explore
monocyte	16 studies	27% ± 11%	Explore
endothelial cell of lymphatic vessel	16 studies	31% ± 11%	Explore
smooth muscle cell	16 studies	20% ± 5%	Explore
ciliated cell	13 studies	28% ± 12%	Explore
epithelial cell	13 studies	32% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	21% ± 5%	Explore
basal cell	12 studies	26% ± 12%	Explore
capillary endothelial cell	12 studies	32% ± 6%	Explore
vein endothelial cell	12 studies	35% ± 8%	Explore
plasmacytoid dendritic cell	12 studies	28% ± 9%	Explore
endothelial cell of vascular tree	11 studies	33% ± 11%	Explore
dendritic cell	11 studies	31% ± 16%	Explore
type I pneumocyte	10 studies	25% ± 9%	Explore
CD4-positive, alpha-beta T cell	10 studies	20% ± 5%	Explore
endothelial cell of artery	10 studies	36% ± 8%	Explore
gamma-delta T cell	10 studies	22% ± 5%	Explore
myeloid cell	10 studies	31% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	29% ± 8%	Explore
CD8-positive, alpha-beta T cell	9 studies	22% ± 4%	Explore
T cell	8 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	18% ± 2%	Explore
myofibroblast cell	8 studies	23% ± 6%	Explore
abnormal cell	8 studies	31% ± 11%	Explore
non-classical monocyte	7 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	21% ± 7%	Explore
connective tissue cell	7 studies	26% ± 4%	Explore
microglial cell	7 studies	29% ± 13%	Explore
neutrophil	6 studies	28% ± 10%	Explore
mature NK T cell	6 studies	24% ± 8%	Explore
neuron	6 studies	41% ± 18%	Explore
memory B cell	6 studies	18% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 5%	Explore
regulatory T cell	6 studies	20% ± 5%	Explore
secretory cell	5 studies	28% ± 9%	Explore
B cell	5 studies	19% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
plasma cell	4 studies	29% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
kidney loop of Henle epithelial cell	4 studies	22% ± 7%	Explore
GABAergic neuron	4 studies	22% ± 6%	Explore
glutamatergic neuron	4 studies	29% ± 4%	Explore
retinal ganglion cell	4 studies	66% ± 29%	Explore
astrocyte	4 studies	28% ± 11%	Explore
Mueller cell	4 studies	18% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 14%	Explore
innate lymphoid cell	4 studies	26% ± 7%	Explore
enteroendocrine cell	4 studies	29% ± 13%	Explore
goblet cell	4 studies	23% ± 7%	Explore
interneuron	4 studies	29% ± 15%	Explore
plasmablast	3 studies	46% ± 10%	Explore
platelet	3 studies	15% ± 0%	Explore
pancreatic A cell	3 studies	46% ± 22%	Explore
hematopoietic precursor cell	3 studies	22% ± 6%	Explore
glomerular endothelial cell	3 studies	31% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	18% ± 2%	Explore
renal alpha-intercalated cell	3 studies	24% ± 5%	Explore
lymphocyte	3 studies	26% ± 6%	Explore
club cell	3 studies	18% ± 2%	Explore
type II pneumocyte	3 studies	32% ± 13%	Explore
amacrine cell	3 studies	36% ± 8%	Explore
retina horizontal cell	3 studies	23% ± 9%	Explore
mononuclear phagocyte	3 studies	25% ± 11%	Explore
intermediate monocyte	3 studies	31% ± 15%	Explore
endothelial cell of sinusoid	3 studies	30% ± 17%	Explore
muscle cell	3 studies	29% ± 14%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
leukocyte	3 studies	21% ± 5%	Explore
glial cell	3 studies	27% ± 12%	Explore
T follicular helper cell	3 studies	24% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 1%	Explore
transit amplifying cell	3 studies	23% ± 5%	Explore
brush cell	3 studies	24% ± 6%	Explore
oligodendrocyte	3 studies	19% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	24% ± 9%	Explore
peripheral blood	11 studies	22% ± 4%	Explore
brain	8 studies	26% ± 7%	Explore
kidney	7 studies	18% ± 2%	Explore
eye	4 studies	19% ± 4%	Explore
intestine	4 studies	23% ± 9%	Explore
bone marrow	3 studies	17% ± 1%	Explore
uterus	3 studies	29% ± 11%	Explore
lymph node	3 studies	24% ± 8%	Explore
liver	3 studies	31% ± 10%	Explore
breast	3 studies	22% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	20883.64	258 / 258	100%	257.31	230 / 230
esophagus	100%	9413.65	1445 / 1445	100%	121.33	183 / 183
ovary	100%	7715.71	180 / 180	100%	241.55	430 / 430
brain	100%	11846.08	2640 / 2642	100%	249.57	705 / 705
thymus	100%	11475.16	653 / 653	100%	239.74	604 / 605
kidney	100%	11929.56	89 / 89	100%	212.16	899 / 901
prostate	100%	11206.68	245 / 245	100%	199.03	500 / 502
lung	100%	13274.36	578 / 578	100%	207.32	1150 / 1155
uterus	100%	10818.66	170 / 170	100%	219.08	457 / 459
liver	100%	6331.50	225 / 226	100%	158.63	406 / 406
intestine	100%	11286.41	966 / 966	99%	165.04	524 / 527
breast	100%	12416.19	459 / 459	99%	243.06	1111 / 1118
stomach	100%	7343.97	359 / 359	99%	137.34	284 / 286
bladder	100%	12441.33	21 / 21	99%	187.88	500 / 504
skin	98%	6110.86	1767 / 1809	100%	402.22	472 / 472
pancreas	98%	4754.20	320 / 328	100%	211.78	178 / 178
adipose	100%	12468.13	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	243.78	80 / 80
lymph node	0%	0	0 / 0	100%	180.71	29 / 29
muscle	100%	9132.00	803 / 803	0%	0	0 / 0
spleen	100%	12854.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	150.95	45 / 45
ureter	0%	0	0 / 0	100%	116.50	1 / 1
peripheral blood	100%	26910.68	928 / 929	0%	0	0 / 0
blood vessel	100%	11477.59	1333 / 1335	0%	0	0 / 0
heart	100%	12062.92	858 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032728	Biological process	positive regulation of interferon-beta production
GO_0072659	Biological process	protein localization to plasma membrane
GO_0032226	Biological process	positive regulation of synaptic transmission, dopaminergic
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0032092	Biological process	positive regulation of protein binding
GO_0051580	Biological process	regulation of neurotransmitter uptake
GO_1901890	Biological process	positive regulation of cell junction assembly
GO_0022617	Biological process	extracellular matrix disassembly
GO_0002090	Biological process	regulation of receptor internalization
GO_0045807	Biological process	positive regulation of endocytosis
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0048643	Biological process	positive regulation of skeletal muscle tissue development
GO_0044857	Biological process	plasma membrane raft organization
GO_1901741	Biological process	positive regulation of myoblast fusion
GO_0007409	Biological process	axonogenesis
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0050821	Biological process	protein stabilization
GO_0035023	Biological process	regulation of Rho protein signal transduction
GO_0044854	Biological process	plasma membrane raft assembly
GO_2000049	Biological process	positive regulation of cell-cell adhesion mediated by cadherin
GO_0034116	Biological process	positive regulation of heterotypic cell-cell adhesion
GO_0070528	Biological process	protein kinase C signaling
GO_0001819	Biological process	positive regulation of cytokine production
GO_0071360	Biological process	cellular response to exogenous dsRNA
GO_0033227	Biological process	dsRNA transport
GO_0034143	Biological process	regulation of toll-like receptor 4 signaling pathway
GO_0034141	Biological process	positive regulation of toll-like receptor 3 signaling pathway
GO_0016324	Cellular component	apical plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0034451	Cellular component	centriolar satellite
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0045121	Cellular component	membrane raft
GO_0016020	Cellular component	membrane
GO_0005769	Cellular component	early endosome
GO_0005815	Cellular component	microtubule organizing center
GO_0042383	Cellular component	sarcolemma
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0098691	Cellular component	dopaminergic synapse
GO_0044291	Cellular component	cell-cell contact zone
GO_0016600	Cellular component	flotillin complex
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0098982	Cellular component	GABA-ergic synapse
GO_0048786	Cellular component	presynaptic active zone
GO_0005912	Cellular component	adherens junction
GO_0008180	Cellular component	COP9 signalosome
GO_0005768	Cellular component	endosome
GO_0030027	Cellular component	lamellipodium
GO_0001931	Cellular component	uropod
GO_0042470	Cellular component	melanosome
GO_0005901	Cellular component	caveola
GO_0005765	Cellular component	lysosomal membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0002020	Molecular function	protease binding
GO_0035255	Molecular function	ionotropic glutamate receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FLOT1
Protein name	Flotillin-1 Flotillin
Synonyms	hCG_2006678
Description	FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. . FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. .
Accessions	A0A140T907 A0A140T959 ENST00000446072.5 ENST00000444632.6 [O75955-1] ENST00000383382.8 [O75955-1] ENST00000430843.5 ENST00000454249.5 ENST00000437093.5 ENST00000445395.1 A0A140T910 ENST00000444497.5 ENST00000420604.1 ENST00000457733.5 ENST00000422636.5 ENST00000427784.5 ENST00000416018.5 ENST00000455034.5 ENST00000418160.5 ENST00000454845.1 A2VCL5 A2ABJ5 Q5ST80 ENST00000411944.5 ENST00000426417.5 A0A140T9L9 ENST00000445383.5 ENST00000431913.5 ENST00000427701.1 A2AB11 ENST00000445669.5 ENST00000430384.5 ENST00000421565.5 ENST00000428438.1 A2AB09 ENST00000456844.1 Q6IB58 ENST00000411848.1 A0A140T9B1 A0A140T9C3 A2AB10 O75955 ENST00000439396.5 A0A140T9R1 ENST00000446416.1 ENST00000454773.5 ENST00000439376.5 A0A140T9H7 A2AB13 ENST00000383562.8 [O75955-1] A0A0G2JJQ6 ENST00000376389.8 [O75955-1] ENST00000436025.1 A2AB12 ENST00000438134.5 ENST00000436197.5 ENST00000432428.5 ENST00000442932.5 A0A140T957 ENST00000444068.5 ENST00000458306.1 ENST00000456042.5 ENST00000411778.5 A0A140T974 A0A140T9X0 ENST00000424683.5 ENST00000439743.1 A0A140T905 A0A140T9W4 ENST00000413165.5 ENST00000416389.5 ENST00000431966.5 ENST00000422714.5 ENST00000445853.5 ENST00000457133.5 ENST00000436822.6 [O75955-1] ENST00000445319.5 ENST00000438162.5

FLOT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review