luminal hormone-sensing cell of mammary gland report

I. Related cell sub types

II. Gene markers

Gene
Number of
supported studies
Average coverage
Other major groups
(express this gene)
Other cell types
(express this gene)
STC2465% ± 7%00
MUCL1433% ± 5%00
VTCN1424% ± 6%01
PTHLH425% ± 7%01
IL20RA321% ± 4%02
LYPD3324% ± 4%04
ANKRD30A466% ± 11%11
TFF1433% ± 8%13
PIP438% ± 8%13
TM4SF18422% ± 4%18
RASEF434% ± 9%18
ZG16B435% ± 12%19
MYBPC1322% ± 1%11
SPDEF342% ± 16%13
PRLR333% ± 4%14
TMC5435% ± 8%116
PRSS22323% ± 8%17
RHOV324% ± 8%18
MUC1432% ± 6%120
BAMBI434% ± 8%24
IRX3429% ± 7%26
CRACR2B448% ± 17%211
FBP1431% ± 10%214
AGR3449% ± 9%215
SCUBE2422% ± 7%33
AR436% ± 12%36
DNAJC12432% ± 11%37
TFAP2A435% ± 3%39
AK5423% ± 3%39
ACADSB427% ± 4%310

III. Associated gene sets

GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0038161Biological processprolactin signaling pathway
GO_0048808Biological processmale genitalia morphogenesis
GO_0042976Biological processactivation of Janus kinase activity
GO_0048645Biological processanimal organ formation
GO_0045726Biological processpositive regulation of integrin biosynthetic process
GO_0070233Biological processnegative regulation of T cell apoptotic process
GO_0060736Biological processprostate gland growth
GO_0030520Biological processestrogen receptor signaling pathway
GO_0030856Biological processregulation of epithelial cell differentiation
GO_0060644Biological processmammary gland epithelial cell differentiation
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_0060748Biological processtertiary branching involved in mammary gland duct morphogenesis

IV. Literature review

[source]
Cell type nameluminal hormone-sensing cell of mammary gland
SynonymsER-positive luminal hormone-sensor cell
DescriptionA luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a).
ParentCL_0000151