MUC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_1902166Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0033629Biological processnegative regulation of cell adhesion mediated by integrin
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0000785Cellular componentchromatin
GO_0031982Cellular componentvesicle
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0002039Molecular functionp53 binding

IV. Literature review

[source]
Gene nameMUC1
Protein nameMUC1 isoform M11
MUC1 isoform T3
MUC1 isoform M16
Mucin short variant S1
Mucin short variant SV8
MUC1 isoform J15
MUC1 isoform J26 (Mucin 1, cell surface associated)
Mucin 1, cell surface associated (Mucin short variant SV10)
Mucin short variant SV2
MUC1 isoform T6
Mucin 1, cell surface associated
Mucin short variant SV7
MUC1 isoform T2
MUC1 isoform M15
MUC1 isoform M13
Mucin-1
Mucin short variant SV3
Mucin short variant PC1
Mucin short variant E1
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
MUC1 isoform T5
MUC1 isoform T4
Mucin short variant SV9
Mucin
MUC1 isoform T1
MUC1 isoform M1
MUC1 isoform M9
MUC1 isoform M14
Mucin short variant PC2
MUC1 isoform M10 (Mucin 1, cell surface associated)
MUC1 isoform J1 (MUC1 isoform J16) (MUC1 isoform J18) (MUC1 isoform J2) (MUC1 isoform J4) (MUC1 isoform J5) (MUC1 isoform J6) (MUC1 isoform J7) (MUC1 isoform J9)
MUC1 isoform T13
MUC1 isoform SV7-LSP
Mucin short variant SV1
MUC1 isoform M4
MUC1 isoform T12
MUC1 isoform J24
MUC1 isoform M5
SynonymsPUM
DescriptionFUNCTION: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; FUNCTION: The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

AccessionsA0A087WTR1
A0A087X061
B6ECA2
ENST00000368392.7 [P15941-11]
ENST00000337604.6 [P15941-8]
ENST00000620103.4
ENST00000343256.9 [P15941-10]
ENST00000438413.5
A5YRU6
A0A0C4DGW3
A0A0A0MRB3
B6EC89
ENST00000342482.8 [P15941-16]
A6ZIE2
ENST00000457295.6
A0A087WVJ0
ENST00000368396.8 [P15941-12]
Q7Z551
B6EC96
A6ZIF0
Q7Z537
A0A087WWM2
A5YRU8
A6ZIE5
ENST00000462215.5
A0A087X0L2
A6ZID8
Q14877
ENST00000485118.5
B6ECA3
Q7Z542
ENST00000368398.7 [P15941-6]
A5YRV2
A6ZIE9
A6ZIE7
A5YRV3
A5YRU4
A5YRU0
A0A087WZZ6
Q7Z539
ENST00000614519.4
A6ZIE4
Q7Z543
Q7Z549
B6ECB1
A6ZID7
ENST00000368393.7 [P15941-13]
ENST00000471283.5
ENST00000498431.5
A6ZID5
Q7Z536
B1AVQ7
Q7Z541
A6ZIE6
ENST00000610468.4
A5YRU7
Q7Z545
A6ZID6
P15941
Q7Z544
A5YRV4
A6ZIF1
A5YRU5
A5YRU2
A0A0A0MSH4
B6ECB3
ENST00000368390.7 [P15941-7]
Q7Z546
Q7Z538
B6ECB2
A5YRU3
B6ECA4
ENST00000615517.4
A6ZIE8
B6ECB0
A6ZIE3
B6ECB5
A6ZIE1
ENST00000467134.5
A6ZID4
A5YRU9
Q7Z540
ENST00000462317.5
A5YRV0
B6ECA9
A5YRU1
ENST00000610359.4
A0A087WZI8
ENST00000368389.6 [P15941-9]
ENST00000338684.9