Name | Number of supported studies | Average coverage | |
---|---|---|---|
hepatocyte | 5 studies | 56% ± 24% | |
oligodendrocyte | 5 studies | 22% ± 5% | |
epithelial cell of proximal tubule | 4 studies | 20% ± 2% | |
endothelial cell | 4 studies | 23% ± 4% | |
epithelial cell | 4 studies | 21% ± 3% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 27% ± 4% | |
GABAergic neuron | 4 studies | 44% ± 17% | |
astrocyte | 4 studies | 29% ± 5% | |
glutamatergic neuron | 3 studies | 59% ± 7% | |
oligodendrocyte precursor cell | 3 studies | 23% ± 6% | |
interneuron | 3 studies | 43% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 3550.21 | 245 / 245 | 100% | 63.05 | 502 / 502 |
liver | 100% | 20400.05 | 226 / 226 | 98% | 89.02 | 397 / 406 |
brain | 99% | 2624.12 | 2623 / 2642 | 93% | 18.03 | 656 / 705 |
breast | 100% | 3199.81 | 458 / 459 | 92% | 68.93 | 1031 / 1118 |
adrenal gland | 100% | 4587.95 | 258 / 258 | 92% | 24.46 | 211 / 230 |
kidney | 100% | 6075.25 | 89 / 89 | 91% | 26.08 | 819 / 901 |
lung | 98% | 1794.94 | 567 / 578 | 88% | 18.12 | 1019 / 1155 |
thymus | 100% | 1899.34 | 653 / 653 | 86% | 13.70 | 522 / 605 |
stomach | 100% | 2263.64 | 359 / 359 | 85% | 13.57 | 243 / 286 |
intestine | 100% | 2318.32 | 965 / 966 | 84% | 12.94 | 441 / 527 |
esophagus | 100% | 2170.28 | 1442 / 1445 | 74% | 11.20 | 135 / 183 |
bladder | 100% | 2277.19 | 21 / 21 | 72% | 11.72 | 362 / 504 |
skin | 100% | 2440.38 | 1806 / 1809 | 71% | 10.52 | 334 / 472 |
pancreas | 99% | 1296.82 | 326 / 328 | 68% | 9.84 | 121 / 178 |
ovary | 100% | 2479.34 | 180 / 180 | 55% | 6.44 | 236 / 430 |
uterus | 100% | 2608.89 | 170 / 170 | 47% | 5.85 | 217 / 459 |
muscle | 100% | 4604.53 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1388.34 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2007.37 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1997.46 | 1331 / 1335 | 0% | 0 | 0 / 0 |
heart | 94% | 3137.14 | 812 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 55% | 6.88 | 16 / 29 |
eye | 0% | 0 | 0 / 0 | 51% | 9.34 | 41 / 80 |
tonsil | 0% | 0 | 0 / 0 | 49% | 6.26 | 22 / 45 |
peripheral blood | 25% | 591.84 | 230 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006550 | Biological process | isoleucine catabolic process |
GO_0006631 | Biological process | fatty acid metabolic process |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0003853 | Molecular function | 2-methylbutanoyl-CoA dehydrogenase activity |
GO_0003995 | Molecular function | acyl-CoA dehydrogenase activity |
GO_0016937 | Molecular function | short-chain fatty acyl-CoA dehydrogenase activity |
GO_0004085 | Molecular function | butyryl-CoA dehydrogenase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
GO_0102035 | Molecular function | 2-methylpropanoyl-CoA dehydrogenase activity |
Gene name | ACADSB |
Protein name | Acyl-CoA dehydrogenase short/branched chain isoform 2 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase) Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-methylbutyryl-coenzyme A dehydrogenase) |
Synonyms | |
Description | FUNCTION: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA . Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA . Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway . Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug . . |
Accessions | A0A0S2Z3P9 ENST00000368869.8 [P45954-2] A0A0S2Z374 ENST00000358776.7 [P45954-1] P45954 |