ACADSB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006550Biological processisoleucine catabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0003853Molecular function2-methylbutanoyl-CoA dehydrogenase activity
GO_0003995Molecular functionacyl-CoA dehydrogenase activity
GO_0016937Molecular functionshort-chain fatty acyl-CoA dehydrogenase activity
GO_0004085Molecular functionbutyryl-CoA dehydrogenase activity
GO_0042802Molecular functionidentical protein binding
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0102035Molecular function2-methylpropanoyl-CoA dehydrogenase activity

IV. Literature review

[source]
Gene nameACADSB
Protein nameAcyl-CoA dehydrogenase short/branched chain isoform 2
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-methylbutyryl-coenzyme A dehydrogenase)
Synonyms
DescriptionFUNCTION: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA . Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA . Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway . Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug . .

AccessionsA0A0S2Z3P9
ENST00000368869.8 [P45954-2]
A0A0S2Z374
ENST00000358776.7 [P45954-1]
P45954